Emerging polymeric material strategies for cartilage repair

Demott, Connor J.; Grunlan, Melissa A.

doi:10.1039/d2tb02005j

Cited by 3 publications

(2 citation statements)

References 139 publications

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“…Moreover, the tested animal model should be considered because articular cartilage’s mechanical properties vary among species ( Athanasiou et al, 1991 ). A confined compression test on bovine articular cartilage shows that the compressive aggregate modulus is between 0.08 and 2.10 MPa ( Schinagl et al, 1997 ; Demott and Grunlan, 2022 ). Yet there are inconsistent values of compressive modulus measurement in joints obtained in different laboratories.…”

Section: Composition and Mechanical Properties Of Articular Cartilagementioning

confidence: 99%

Strategy insight: Mechanical properties of biomaterials’ influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

Shen

Pan

et al. 2023

Front. Pharmacol.

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Osteoarthritis (OA) is a kind of degenerative joint disease usually found in older adults and those who have received meniscal surgery, bringing great suffering to a number of patients worldwide. One of the major pathological features of OA is retrograde changes in the articular cartilage. Mesenchymal stromal cells (MSCs) can differentiate into chondrocytes and promote cartilage regeneration, thus having great potential for the treatment of osteoarthritis. However, improving the therapeutic effect of MSCs in the joint cavity is still an open problem. Hydrogel made of different biomaterials has been recognized as an ideal carrier for MSCs in recent years. This review focuses on the influence of the mechanical properties of hydrogels on the efficacy of MSCs in OA treatment and compares artificial materials with articular cartilage, hoping to provide a reference for further development of modified hydrogels to improve the therapeutic effect of MSCs.

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Section: Composition and Mechanical Properties Of Articular Cartilagementioning

confidence: 99%

Strategy insight: Mechanical properties of biomaterials’ influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

Shen

Pan

et al. 2023

Front. Pharmacol.

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“…Cartilage tissue injury is one of the common but not self-healable diseases in clinical orthopedics. − Artificial cartilage scaffolds have excellent mechanical and biological performance toward mimetic tissue environments and greatly relieve the patients’ physical and psychological distress. − To date, approaches to transplantation of these scaffolds have been widely applied as ideal replacements for traditional therapies for cartilage tissue regeneration and repair. Material matrices are indispensable parts in this field and play critical roles in realizing these properties. ,− Typically, porous, water-rich hydrogels are able to mimic extracellular matrices and provide similar microenvironments for cell proliferation, nutrition delivery, and tissue generation. − The introduction of functional components in hydrogels will improve their mechanical property, biocompatibility, diagnosis, and therapy performances.…”

Section: Introductionmentioning

confidence: 99%

Customizable Low-Friction Tough Hydrogels for Potential Cartilage Tissue Engineering by a Rapid Orthogonal Photoreactive 3D-Printing Design

Cheng

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Hydrogels have demonstrated wide applications in tissue engineering, but it is still challenging to develop strong, customizable, lowfriction artificial scaffolds. Here, we report a rapid orthogonal photoreactive 3Dprinting (ROP3P) strategy to achieve the design of high-performance hydrogels in tens of minutes. The orthogonal ruthenium chemistry enables the formation of multinetworks in hydrogels via phenol-coupling reaction and traditional radical polymerization. Further Ca 2+ -cross-linking treatment greatly improves their mechanical properties (6.4 MPa at a critical strain of 300%) and toughness (10.85 MJ m −3 ). The tribological investigation reveals that the high elastic moduli of the as-prepared hydrogels improve their lubrication (∼0.02) and wear-resistance performances. These hydrogels are biocompatible and nontoxic and promote bone marrow mesenchymal stem cell adhesion and propagation. The introduction of 1-hydroxy-3-(acryloylamino)-1,1-propanediylbisphosphonic acid units can greatly enhance their antibacterial property to kill typical Escherichia coli and Staphylococcus aureus. Moreover, the rapid ROP3P can achieve hydrogel preparation in several seconds and is readily compatible with making artificial meniscus scaffolds. The printed meniscus-like materials are mechanically stable and can maintain their shape under long-term gliding tests. It is anticipated that these high-performance customizable low-friction tough hydrogels and the highly efficient ROP3P strategy could promote further development and practical applications of hydrogels in biomimetic tissue engineering, materials chemistry, bioelectronics, and so on.

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3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering – A review

Xu,

Zhang,

Zhang

et al. 2024

Materials & Design

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Emerging polymeric material strategies for cartilage repair

Abstract: The recent rise of polymeric materials for cartilage regenerative engineering and tissue-mimetic synthetic replacements is paving way for a new generation of materials with improved clinical outcomes.

Cited by 3 publications

References 139 publications

Strategy insight: Mechanical properties of biomaterials’ influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

Strategy insight: Mechanical properties of biomaterials’ influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

Customizable Low-Friction Tough Hydrogels for Potential Cartilage Tissue Engineering by a Rapid Orthogonal Photoreactive 3D-Printing Design

3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering – A review

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