Cartilage Lacuna‐Inspired Microcarriers Drive Hyaline Neocartilage Regeneration (Adv. Mater. 30/2023)

Abstract

Cartilage Tissue Engineering In article number 2212114, Wenguo Cui, Qi Gu, Ming‐Zhu Zhang, and co‐workers introduce novel cartilage lacuna‐inspired microcarriers with geometric constraints to repress chondrocyte dedifferentiation by inhibiting Wnt signaling. The biomimetic microcarriers display favorable cytocompatibility and drive robust hyaline chondrocyte‐derived neocartilage formation. This study paves the way for deciphering the geometrical insights into the interactional mechanism of mechanotransduction in regulating cell fate.

Fabrication of polymeric microspheres for biomedical applications

“…This special surface topography could repress chondrocyte dedifferentiation and promote neocartilage formation via geometric constraints. 218 Microspheres with rough surfaces show improved adhesion efficiency on the surface compared to those with smooth surfaces. 219,220 Surface chemistry is another important property of microspheres, which is highly tunable for their optimization.…”