Fabrication of polymeric microspheres for biomedical applications

Li, Xuebing; Li, Luohuizi; Wang, Dehui; Zhang, Jun; Yi, Kangfeng; Su, Yucai; Luo, Jing; Deng, Xu; Deng, Fei

doi:10.1039/d3mh01641b

Cited by 8 publications

(2 citation statements)

References 323 publications

(433 reference statements)

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“…Researchers explore different formulations of polymers, solvents, and bioactive agents to achieve the desired physical and chemical properties. Additionally, optimization extends to temperature and processing time, crucial variables that impact the formation of well-defined nanofibrous structures . In cases where electrospraying is employed, parameters like voltage, flow rate, and needle-to-collector distance require careful optimization to ensure uniform fiber deposition and prevent irregularities .…”

Section: Translational Considerationsmentioning

confidence: 99%

“…Additionally, optimization extends to temperature and processing time, crucial variables that impact the formation of well-defined nanofibrous structures. 156 In cases where electrospraying is employed, parameters like voltage, flow rate, and needle-to-collector distance require careful optimization to ensure uniform fiber deposition and prevent irregularities. 157 The selection and optimization of cross-linking methods, where applicable, further enhance the stability and biocompatibility of NFMS.…”

Section: Translational Considerationsmentioning

confidence: 99%

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Section: Translational Considerationsmentioning

confidence: 99%

Section: Translational Considerationsmentioning

confidence: 99%