Carriage of antibiotic-resistant Haemophilus influenzae strains in children undergoing adenotonsillectomy

Trafny, Elżbieta Anna; Olszewska-Sosińska, Olga; Antos-Bielska, Małgorzata; Kozłowska, K; Stępińska, Małgorzata; Lau-Dworak, Magdalena; Zielnik-Jurkiewicz, Beata

doi:10.1016/j.ijmm.2014.03.004

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…For example, although Van Staaij and colleagues found similar rates of detection of H. influenzae in patients with and without chronic adenotonsillar disease, this bacterium was significantly more frequent in patients with more severe tonsillar hypertrophy. This result was in agreement with other published studies [ 37 – 39 ]. In addition, Brodsky et al [ 32 ] found in H. influenzae a significant positive association between high bacterial load and tonsil weight.…”

Section: Discussionsupporting

confidence: 94%

The Relationship between Colonization by Moraxella catarrhalis and Tonsillar Hypertrophy

Prates

Tamashiro

Proença-Módena

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

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We sought to investigate the prevalence of potentially pathogenic bacteria in secretions and tonsillar tissues of children with chronic adenotonsillitis hypertrophy compared to controls. Prospective case-control study comparing patients between 2 and 12 years old who underwent adenotonsillectomy due to chronic adenotonsillar hypertrophy to children without disease. We compared detection of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Pseudomonas aeruginosa, and Moraxella catarrhalis by real-time PCR in palatine tonsils, adenoids, and nasopharyngeal washes obtained from 37 children with and 14 without adenotonsillar hypertrophy. We found high frequency (>50%) of Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and Pseudomonas aeruginosa in both groups of patients. Although different sampling sites can be infected with more than one bacterium and some bacteria can be detected in different tissues in the same patient, adenoids, palatine tonsils, and nasopharyngeal washes were not uniformly infected by the same bacteria. Adenoids and palatine tonsils of patients with severe adenotonsillar hypertrophy had higher rates of bacterial coinfection. There was good correlation of detection of Moraxella catarrhalis in different sampling sites in patients with more severe tonsillar hypertrophy, suggesting that Moraxella catarrhalis may be associated with the development of more severe hypertrophy, that inflammatory conditions favor colonization by this agent. Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalis are frequently detected in palatine tonsils, adenoids, and nasopharyngeal washes in children. Simultaneous detection of Moraxella catarrhalis in adenoids, palatine tonsils, and nasopharyngeal washes was correlated with more severe tonsillar hypertrophy.

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Section: Discussionsupporting

confidence: 94%

The Relationship between Colonization by Moraxella catarrhalis and Tonsillar Hypertrophy

Prates

Tamashiro

Proença-Módena

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Antibiotics are generally not sufficient modes of treatment for adenoid hypertrophy, as many infections are characterized by highly resistant bacteria that do not respond to many groups of antibiotics [74,75]. Additionally, many viruses are often associated with adenoid hypertrophy, including human bocavirus [76,77], EBV, and polymoviruses [76].…”

Section: Non-surgical Therapy For Adenoid Hypertrophymentioning

confidence: 99%

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

Schüpper

Nation

Pransky

2018

Curr Otorhinolaryngol Rep

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Purpose of Review Review the current state of the adenoidectomy procedure in the pediatric population with up-to-date indications for surgery, operative techniques, adverse events, non-surgical management of adenoid hypertrophy, and future directions. Recent Findings Adenoidectomy is indicated in children for the treatment of sleep-disordered breathing, nasal airway obstruction, recurrent acute otitis media, and chronic rhinosinusitis. A new recommendation was released in 2016, not supporting adenoidectomy for a primary indication of otitis media in children under 4 years old, including those with prior tympanostomy tubes, unless a distinct indication exists such as nasal obstruction or chronic adenoiditis. Although adenotonsillectomy is the mainstay of treatment for obstructive sleep apnea (OSA), recent studies have identified that non-obese patients with moderate OSA and small tonsils have comparable benefits with adenoidectomy alone with less complications. While conventional approaches such as indirect mirror-assisted curette and suction coagulation are still utilized, direct transnasal endoscopeassisted removal of the adenoids has proven to be a safe technique, with good short-and long-term outcomes. Novel nonsurgical therapies including immunotherapy have been evaluated. Summary Adenoidectomy is a safe procedure in the pediatric population and leads to excellent outcomes. Adverse events are rare, and hospitalization is uncommon. Children with sleep disturbance from nasal airway obstruction, ear disease, or chronic rhinosinusitis are the best operative candidates for this procedure.

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“…Systemic complications, i.e. pneumonia, meningitis, or sepsis, represent a trifling fraction -only 0.2% -of postoperative morbidity [2,22,23].…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Perioperative Antibiotic Therapy in Tonsillectomy Patients

Orłowski¹,

Lisowska²,

Misiołek³

et al. 2016

Adv Clin Exp Med

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Carriage of antibiotic-resistant Haemophilus influenzae strains in children undergoing adenotonsillectomy

Cited by 5 publications

References 44 publications

The Relationship between Colonization by Moraxella catarrhalis and Tonsillar Hypertrophy

The Relationship between Colonization by Moraxella catarrhalis and Tonsillar Hypertrophy

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

The Efficacy of Perioperative Antibiotic Therapy in Tonsillectomy Patients

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