Carrageenans from chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity

Cáceres, Pablo J.; Carlucci, María Josefina; Damonte, Elsa B.; Matsuhiro, Betty; Zúñiga, Elisa A.

doi:10.1016/s0031-9422(99)00461-6

Cited by 132 publications

(65 citation statements)

References 37 publications

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“…Carrageenan is a selective inhibitor of several enveloped viruses, including such human pathogens as human immunodeficiency virus, herpes simplex virus (HSV), human cytomegalovirus, human rhinoviruses and others (Girond et al 1991;Marchetti et al 1995;Carlucci et al 1999;Caceres et al 2000;Zacharopoulos and Phillips 1997;Stiles et al 2008). Carrageenan acts primarily by preventing the binding or the entry of virions into cells (Buck et al 2006, Grassauer et al 2008).…”

Section: Antiviral Activitymentioning

confidence: 99%

Carrageenan: a review

Nečas¹,

2013

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Carrageenan is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. The name Carrageenan is derived from the Chondrus crispus species of seaweed known as Carrageen Moss or Irish Moss in England, and Carraigin in Ireland. Carraigin has been used in Ireland since 400 AD as a gelatin and as a home remedy to cure coughs and colds. It grows along the coasts of North America and Europe. Carrageenans are used in a variety of commercial applications as gelling, thickening, and stabilising agents, especially in food products and sauces. Aside from these functions, carrageenans are used in experimental medicine, pharmaceutical formulations, cosmetics, and industrial applications.Keywords: carrageenan; pharmacokinetics; toxicity; biological activity List of abbreviations 3,6-AG = 3,6, anhydro-galactose, 5-HT = 5-hydroxytryptamine, 6-APA = 6-amino penicillanic acid, ADI = acceptable daily intake, AG = amino guanidine, AIDS = acquired immune deficiency syndrome, AT-III = anti-thrombin-III, bw = body weight, COX-2 = cyclooxygenase-2, eNOS = endothelial nitric oxide synthase, FAO = food and agriculture organization, HC-II = heparin co-factor II, HIV = human immunodeficiency virus, HPV = human papilloma virus, HSV = herpes simplex virus, IFAC = international food additives council, iNOS = inducible nitric oxide synthase, JECFA = Joint FAO/WHO Expert Committee on Food Additives, L-NMMA = NG-monomethyl-l-arginine, nNOS = neuronal nitric oxide synthase, NO = nitric oxide, NOS = nitric oxide synthase, NSAIDs = non-steroidal antiinflammatory drugs, PGs = prostaglandins, SSL = sodium stearoyl lactylate, TNF-α = tumour necrosis factor-α

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Section: Antiviral Activitymentioning

confidence: 99%

Carrageenan: a review

Nečas¹,

2013

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“…The sulfated fucans present an inexpensive and easy source of anticoagulants with little or no adverse effect. Among other natural polymers, carrageenan has also been shown to exhibit an anticoagulant effect [ 27 ].…”

Section: Natural Polymers With Anticoagulant Activitymentioning

confidence: 99%

Functions of Bioactive and Intelligent Natural Polymers in the Optimization of Drug Delivery

Ngwuluka

Ochekpe

Aruoma

2016

Industrial Applications for Intelligent Polymers and Coatings

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Bioactive polymers, by their structural confi guration and conformation, possess the ability to exert biological activities and consequently elicit responses from cells and tissues. Intelligent polymers are smart polymers which respond to internal and external stimuli in order to propel the release or modify the release of drugs. Natural polymers are biogenic, biocompatible, biodegradable, and safe for consumption. Consequently, they present as suitable materials that the human body can identify with and not treat as foreign bodies, thereby reducing the complications encountered when dealing with synthetic polymers. Natural polymers have been shown to be bioactive, exhibiting biological activities such as antitumor, anticoagulant, antioxidant, antimicrobial, antiulcer, anti-infl ammatory, and antirheumatic. In addition, natural polymers are meritorious materials for the fabrication of selfregulated or externally regulated drug delivery systems. These systems respond to the state of the environment for effi cacious therapy. Drug delivery technology is shifting from the controlled release of drugs over time to the release of drugs when and where needed, especially for chronic diseases. Indeed, intelligent polymers are choice polymers for such delivery systems. Their synthetic counterparts were actually synthesized to mimic these natural polymers which further buttress the need to revert to nature for intelligent and bioactive polymers. The contexts of natural bioactive and intelligent polymers have unique applications in drug delivery, embracing nanobiotechnology. This would ultimately benefi t drug delivery systems in benchmarking new drug formulations.

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“…New research on the biocide properties shows that applications of carrageenan gels from C. crispus may block the transmission of the HIV virus as well as other STD viruses such as gonorrhoea, genital warts and the herpes simplex virus (HSV) (Caceres et al 2000;Carlucci et al 1997;Luescher-Mattli 2003;Shanmugam and Mody 2000;Witvrouw and DeClercq 1997). In addition, carrageenans are good candidates for use as vaginal microbicides because they do not exhibit significant levels of cytotoxicity or anti-coagulant activity (Buck et al 2006;Zeitlin et al 1997).…”

Section: Carrageenansmentioning

confidence: 99%