Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing

Yegappan, Ramanathan; Selvaprithiviraj, Vignesh; Amirthalingam, Sivashanmugam; Jayakumar, R.

doi:10.1016/j.carbpol.2018.06.086

Cited by 362 publications

(195 citation statements)

References 180 publications

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“…Six classes of carrageenans, named Kappa (κ)‐, Iota(ι)‐, Lambda (λ)‐, Mu (μ)‐, Nu (ν)‐ and Theta (θ), exist based on their different structures (Cunha & Grenha, ). CRG hydrogels are popular choices for drug delivery, tissue engineering and wound healing (Yegappan, Selvaprithiviraj, Amirthalingam, & Jayakumar, ). The preparation of microspherical κ‐carrageenan gel particles, using emulsion technology, affects the final aerogel properties (Alnaief, Obaidat, & Mashaqbeh, ; Obaidat, Alnaief, & Mashaqbeh, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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“…Polysaccharides by itself or in combination with other macromolecules extensively contribute in formation of tissue engineering hydrogels . The presence of abundant functional groups has made them very competent for chemical modification and gelation . Pectin is a heteropolysaccharide composed of partially esterified galacturonic acid units.…”

Section: Introductionmentioning

confidence: 99%

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

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Hydrogels possessing high mechanical strength and well-controlled properties are of utmost interest in bone tissue engineering. In the current study, a strong self-crosslinked hydrogel with variable properties has been developed from a combinatory composition of functionalized pectin and silk fibroin. Pectin chains underwent partial oxidation to be decorated with aldehyde functionalities. Later on, functionalized polysaccharide and protein were blended with different ratios, and corresponding variations in crystalline structure as well as in morphological, mechanical, and rheological properties have been monitored. Some theories have been used to better perceive the relation between blending ratio and hydrogel properties. Avrami equation based on time sweep rheological analysis elucidated that in sample with equivalent ratio of oxidized pectin and fibroin, the crystallization was highly delayed due to dominance of Schiff's base reaction. The Herschel-Bulkley model based on flow curve rheology test corroborated that aforesaid composition revealed the most noticeable shear thinning behavior and accordingly the strongest crosslinked network. Finally, rubber elastic theory based on dynamic mechanical analysis implied that said formulation possessed the highest crosslinking density due to higher availability of aldehyde to amine functionalities. Moreover, cell culture studies proved that P50 F50 sample prevailed over other compositions with respect to cell viability and function.

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“…For instance, pH-sensitive alginate hydrogel has been developed to load vanillin and achieved the pulsatile drug release. [3] In recent years, natural polymer hydrogels have been demonstrated with the potential as wound dressings because they can afford a moist environment to promote the wound healing. [2] Carrageenan based hydrogel has been exploited in the fields of bone and cartilage tissue engineering.…”

mentioning

confidence: 99%

“…[2] Carrageenan based hydrogel has been exploited in the fields of bone and cartilage tissue engineering. [3] In recent years, natural polymer hydrogels have been demonstrated with the potential as wound dressings because they can afford a moist environment to promote the wound healing. [4][5][6][7][8] Especially, these hydrogel-based dressings present various properties such as absorbing exudates from wounds, in situ encapsulating drugs and filling irregular wound sites, Global Challenges 2020, 4,1900068 HA with cystamine dihydrochloride (CD) and disulfide bond cleavage.…”

mentioning

confidence: 99%

Mussel‐Inspired Adhesive Polydopamine‐Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition

Zhang

Jiang

et al. 2019

Global Challenges

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etc. Among them, hyaluronic acid (HA)derived hydrogel is one of the ideal candidates due to its inherent biological homology, feasible structure modification, as well as good degradability. [9,10] The high water retention capacity and high viscoelasticity of HA also allow it to be suitable for wound dressings.To construct desirable HA-based hydrogels, different strategies have been established. Relying on the intermolecular noncovalent interactions, the physical cross-linking HA hydrogels emerged. Rodell et al. developed a shearthinning and self-healing HA hydrogel due to the host-guest interaction between β-cyclodextrin (β-CD) and adamantine (AD) appended HA. [11] The hydrogel properties could be rationally tailored through the material concentration, degree of modification, and the ratio of β-CD to AD. Nevertheless, the physical hydrogels may exhibit undesirable mechanical properties and suffer from premature dissociation. Chemical crosslinking of pendant reactive groups by coordination chemistry or polymerization ignites an alternative route to fabricate HAbased hydrogels. In the meanwhile, transition metal ions or exogenous cross-linking agents usually involve, [12] which may impair the systemic biocompatibility due to their possible cytotoxicity. Recently, various compatible strategies have been proposed to develop biocompatible hydrogels, such as enzymemediated covalent linking, [13,14] disulfide cross-linking, [15,16] and Diels-Alder reaction. [17,18] Indeed, these chemical cross-linked hydrogels exhibit good mechanical property and are cytocompatible. However, their further applications are restricted by their limited functions. Thus, endowing HA hydrogels with multiple functions seems to be very promising, and fabricating HA-based functional hydrogels with good biocompatibility is still challengeable.In this study, a multifunctional hydrogel (PDA-HA) comprising of polydopamine (PDA) and thiolated hyaluronic acid (HA-SH) is developed (Scheme 1). PDA was introduced because of its good biocompatibility, strong tissue adhesion and effective free radical scavenging ability. Specially, it could act as the nanosized cross-linking agent that reacts with thiolated HA via Michael addition. The biocompatibility, gelling ability, tissue adhesion, free radical scavenging, and bacterial inhibition of the hybrid hydrogel were evaluated. The potential bacterial inhibition and good tissue adhesion endow the hydrogel with great potential for wound dressing.As shown in Figure 1A, thiolated hyaluronic acid (HA-SH) was obtained by two steps that referred to the amidation of Hyaluronic acid (HA)-based hydrogels have been receiving increasing attention for wound management. However, pure HA hydrogels usually exhibit weak mechanical strength and poor anti-infection. Herein, a hybrid HA-based hydrogel (PDA-HA) comprised of polydopamine (PDA) and thiolated hyaluronic acid (HA-SH) is developed based on the Michael addition reaction. The introduction of PDA into HA hydrogel can decrease the critical gel concentration, improve the c...

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Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing

Cited by 362 publications

References 180 publications

Carbohydrate‐based nanomaterials for biomedical applications

Carbohydrate‐based nanomaterials for biomedical applications

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Mussel‐Inspired Adhesive Polydopamine‐Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition

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