Caroverine in Tinnitus Treatment

Domeisen, Hannes; Hotz, Michel A.; Häusler, Rudolf

doi:10.1080/00016489850154801

Cited by 30 publications

(4 citation statements)

References 5 publications

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“…Other drugs already studied for treatment of tinnitus are lidocaine,[12] antidepressants,[13] baclofen,[14] caroverine,[15] nimodipine,[16] clonazepam[17] and trimetazidine. [18] The introduction of these drug therapies have increased the success of tinnitus treatment.…”

Section: Discussionmentioning

confidence: 99%

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Role of acamprosate in sensorineural tinnitus

et al. 2012

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Acamprosate with dual mechanism of action as glutamate antagonist and GABA agonist can be a potential target to decrease the severity of sensorineural tinnitus.Objective:(1)To study the effectiveness of acamprosate in providing subjective relief and objective improvement in patients having tinnitus of sensorineural origin. (2) To evaluate the adverse events related to the use of acamprosate and also determine the change in quality of life (QOL) parameters.Materials and Methods:The study was randomized double-blind, placebo controlled, crossover. Forty adult subjects (>18 years of age), of either sex with tinnitus of sensorineural origin, were administered either acamprosate 333 mg TDS or matched placebo for a period of six weeks followed by a washout period of one week. Drug therapy was switched for another six weeks in consonance with the crossover design. The effect of acamprosate and placebo on subjective relief and objective improvement was evaluated by using modified tinnitus severity, QOL scores and audiometry with tinnitus matching in frequency and loudness.Results:At the end of the study, the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients. The drug was well tolerated without any serious drug reactions.Conclusion:Acamprosate is an effective drug in treating the severity of sensorineural tinnitus without causing much of the side effects.

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Section: Discussionmentioning

confidence: 99%

“…However, the systemic use of nonselective glutamate receptor blockers such as caroverine is limited by severe neurological and psychiatric side effects. [15]…”

Section: Discussionmentioning

confidence: 99%

Role of acamprosate in sensorineural tinnitus

et al. 2012

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“…A single intravenous injection of caroverine was found to immediately alleviate tinnitus in 63% of patients, with 43% of those who showed improvement continuing to show improvement one week after treatment [ 63 ]. In contrast, a second study using the same design found that caroverine did not demonstrate any significant therapeutic effects [ 64 ]. Memantine is a voltage-dependent antagonist against NMDA receptors that decreases excitotoxicity by reducing calcium influx, which has been approved for treatment of patients with Alzheimer’s disease [ 65 ].…”

Section: Medications For Tinnitusmentioning

confidence: 99%

Review of Pharmacotherapy for Tinnitus

Kim

Lee

et al. 2021

Healthcare

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Various medications are currently used in the treatment of tinnitus, including anesthetics, antiarrhythmics, anticonvulsants, antidepressants, antihistamines, antipsychotics, anxiolytics, calcium channel blockers, cholinergic antagonists, NMDA antagonists, muscle relaxants, vasodilators, and vitamins. To date, however, no medications have been specifically approved to treat tinnitus by the US Food and Drug Administration (FDA). In addition, medicines used to treat other diseases, as well as foods and other ingested materials, can result in unwanted tinnitus. These include alcohol, antineoplastic chemotherapeutic agents and heavy metals, antimetabolites, antitumor agents, antibiotics, caffeine, cocaine, marijuana, nonnarcotic analgesics and antipyretics, ototoxic antibiotics and diuretics, oral contraceptives, quinine and chloroquine, and salicylates. This review, therefore, describes the medications currently used to treat tinnitus, including their mechanisms of action, therapeutic effects, dosages, and side-effects. In addition, this review describes the medications, foods, and other ingested agents that can induce unwanted tinnitus, as well as their mechanisms of action.

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“…A larger clinical trial is currently underway to analyze the encouraging results from this preliminary study (http://clinicaltrials.gov/ct2/show/ NCT00596531). Treatment with intravenous caroverine, an antagonist of non-NMDA and NMDA receptors, has been analyzed, with contradictory results [50,51]. In a prospective, randomized, double-blind cross-over study using the Tinnitus Handicap Inventory to assess efficacy, 90-day treatment with the non-selective NMDA antagonist memantine was no more effective than placebo [52].…”

Section: Pharmacological Treatment Of Tinnitusmentioning

confidence: 99%