Carotid Plaque Characteristics and Disease Activity in Rheumatoid Arthritis

Semb, Anne Grete; Rollefstad, Silvia; Provan, Sella Aarrestad; Kvien, Tore K; Stranden, Einar; Olsen, I.C.; Hisdal, Jonny

doi:10.3899/jrheum.120621

Cited by 88 publications

(57 citation statements)

References 38 publications

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“…98 Plaque vulnerability is associ ated with rheumatic disease activity, demonstrating a link between inflammation and plaque composition. 98,99 Plaques in patients with RA who have active disease are more vulnerable than in those with RA in clinical remission. 99 Compared with matched controls without RA, patients with RA have worse outcomes after acute coronary syndrome, with increased deaths and increased and earlier recurrence of MI.…”

Section: Effects On Plaque Compositionmentioning

confidence: 98%

Cardiovascular comorbidity in rheumatic diseases

2015

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Patients with rheumatoid arthritis (RA) and other inflammatory joint diseases (IJDs) have an increased risk of premature death compared with the general population, mainly because of the risk of cardiovascular disease, which is similar in patients with RA and in those with diabetes mellitus. Pathogenic mechanisms and clinical expression of cardiovascular comorbidities vary greatly between different rheumatic diseases, but atherosclerosis seems to be associated with all IJDs. Traditional risk factors such as age, gender, dyslipidaemia, hypertension, smoking, obesity and diabetes mellitus, together with inflammation, are the main contributors to the increased cardiovascular risk in patients with IJDs. Although cardiovascular risk assessment should be part of routine care in such patients, no disease-specific models are currently available for this purpose. The main pillars of cardiovascular risk reduction are pharmacological and nonpharmacological management of cardiovascular risk factors, as well as tight control of disease activity.

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Section: Effects On Plaque Compositionmentioning

confidence: 98%

Cardiovascular comorbidity in rheumatic diseases

2015

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“…In patients with RA, the severity of carotid atherosclerosis is associated with disease activity. 26,27 A recent study highlighted the association among RA flare, cumulative burden of RA disease severity, and increased CVD risk. 56 RA, together with other inflammatory arthritis, may be good models to study the role of inflammation in promoting atherosclerosis.…”

Section: Mechanism Of Inflammation In Cvd In Inflammatorymentioning

confidence: 99%

Targeting inflammation in the prevention of cardiovascular disease in patients with inflammatory arthritis

Shen

Shang

Tam

2016

Translational Research

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“…Accordingly, novel markers of CVD such as impaired insulin sensitivity, endothelial dysfunction, carotid intima-media thickening, and aortic stiffness, have all been associated with inflammation and are found to occur with higher prevalence in patients with CIDs [39][40][41][42][43][44][45][46]. Indeed, the inflammatory mechanisms implicated in the pathogenesis of CIDs resemble the chronic inflammatory processes that also drive the development of atherosclerosis [13,14].…”

Section: Inflammationmentioning

confidence: 99%

Management of Cardiovascular Risk in Patients with Chronic Inflammatory Diseases: Current Evidence and Future Perspectives

Lindhardsen

Kristensen

Ahlehoff

2015

Am J Cardiovasc Drugs

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An increased risk of cardiovascular disease (CVD) has been observed in a range of chronic inflammatory diseases (CID), including rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases (IBD), and systemic lupus erythematosus (SLE). The increased risk of CVDs and reduced life expectancy in these conditions has stimulated considerable research and started an ongoing discussion on the need for a multidisciplinary approach and dedicated guidelines on CVD prevention in these patients. In addition, the possibility of inhibiting inflammation as a means to preventing CVD in these patients has gained considerable interest in recent years. We briefly summarize the current level of evidence of the association between CIDs and CVD and cardiovascular risk management recommendations. Perspectives of ongoing and planned trials are discussed in consideration of potential ways to improve primary and secondary CVD prevention in patients with CID.

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Carotid Plaque Characteristics and Disease Activity in Rheumatoid Arthritis

Abstract: Patients with RA had more CP compared with controls and patients in CDAI remission, and controls had more stable CP than patients with active disease; these findings point to the importance of achieving remission in RA.

Cited by 88 publications

References 38 publications

Cardiovascular comorbidity in rheumatic diseases

Cardiovascular comorbidity in rheumatic diseases

Targeting inflammation in the prevention of cardiovascular disease in patients with inflammatory arthritis

Management of Cardiovascular Risk in Patients with Chronic Inflammatory Diseases: Current Evidence and Future Perspectives

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