Carotid Artery Wall Thickness in Obese and Nonobese Adults With Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatment

Kim, Jin‐Young; Mohler, Emile R.; Keenan, Brendan T.; Maislin, David; Arnardóttir, Erna Sif; Gíslason, Þórarinn; Benediktsdóttir, Bryndís; Gudmundsdóttir, Sigrún; Sifferman, Andrea; Staley, Bethany; Pack, Frances M.; Maislin, Greg; Chirinos, Julio A.; Townsend, Raymond R.; Kuna, Samuel T.

doi:10.1093/sleep/zsx126

Cited by 20 publications

(16 citation statements)

References 32 publications

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“…Previous research indicates that quantitative IMT and QAS techniques, as noninvasive examinations, provides a comprehensive evaluation of CCA remodeling for assessing preclinical atherosclerosis and early-stage diabetes (15,16,30). Although several studies have shown that there are no changes in carotid IMT in OSA patients compared to non-snorers (13,31), substantial evidence indicates a significant increase in OSA patients compared to non-snorers (32). In this study, we creatively used the ultrasound radiofrequency technology to detect changes in the structure and function of the carotid artery in OSA patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

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Objective: Obstructive sleep apnea (OSA) results in increased carotid intima-media thickness (IMT) and arterial stiffness; however, the association between adipocytokines and IMT/arterial stiffness in OSA patients is unclear. Methods:We enrolled 95 normal weight and overweight, not obese, participants from May 2018 to December 2018 in this study. All subjects underwent a carotid artery ultrasound examination and polysomnography. Blood samples were used to determine serum chemerin, adiponectin, SFRP5, and apelin levels. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient.Stepwise models of multiple linear regression analysis were performed to assess the independent relationships.Result: IMT in OSA patients was significantly higher than in the non-snorers. There were significant differences in the arterial stiffness parameters such as distensibility coefficient (DC), compliance coefficient (CC), and pulse wave velocity (PWV). SFRP5 level was lower in OSA patients than in non-snorers. Adiponectin correlated with CC, DC, and PWV among OSA patients; however, the relationship disappeared after a multivariable adjustment. Age was independently associated with all quantitative IMT and stiffness indices. AHI and minimum oxygen saturation (Mini SaO 2 ) were independently related to arterial stiffness. Conclusion:The quantitative IMT and carotid arterial elasticity were significantly worse among OSA patients. Age was the main independent factor correlated with quantitative IMT and arterial stiffness, and AHI and mini SaO 2 were associated factors. There were no relationships between aforementioned adipocytokines and quantitative IMT/carotid arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

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“…The method of OSA diagnosis in PISA was described in detail previously. 16 Subjects were excluded with any unstable or new medical condition in the month prior to screening, severe and uncontrolled arterial hypertension (SBP >180 mmHg; DBP >110 mmHg), BMI >40 kg/m 2 , routine consumption of more than two alcoholic beverages per day, and excessive caffeine use (>10 cups/day). Pregnant women were also excluded.…”

Section: Methodsmentioning

confidence: 99%

“…The method of OSA diagnosis in PISA was described in detail previously. 16 Subjects were excluded with any unstable or new medical condition in the month prior to screening, severe and uncontrolled arterial hypertension (SBP > 180 mm Hg; DBP > 110 mm Hg), BMI > 40 kg/ Subjects were included in the primary analyses if they underwent ABPM during screening for eligibility for PISA, whether or not they were found to have OSA, and if they were not on antihypertensive treatment for ≥2 months prior to screening.…”

Section: Pisa Study Designmentioning

confidence: 99%

Sleep duration and 24‐hour ambulatory blood pressure in adults not on antihypertensive medications

Shulman

Cohen

Grandner

et al. 2018

J of Clinical Hypertension

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Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post-hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure was 12.7 mmHg higher in LIMBS (p<0.001; n=66) and 4.7 mmHg higher in PISA (p=0.005; n=153) among participants with shorter sleep duration (less than seven hours) compared to those with longer sleep duration (at least seven hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic blood pressure on 24-hour ABPM, independent of nocturnal blood pressure and in-office blood pressure. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease.

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“…Additionally, the same group demonstrated that effective treatment with CPAP therapy improves validated markers of atherosclerosis including arterial stiffness and CIMT [2]. However, a larger, more recent study examining the effects of OSA and CPAP on carotid atherosclerosis did not show an increase in CIMT in patients with OSA vs controls and did not show a change in CIMT after PAP therapy [35]. It is important to note that while there are several studies evaluating CIMT in OSA, carotid plaque burden or activity was not measured in these studies.…”

Section: Discussionmentioning

confidence: 99%

Assessment of atherosclerotic plaque activity in patients with sleep apnea using hybrid positron emission tomography/magnetic resonance imaging (PET/MRI): a feasibility study

et al. 2018

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Carotid Artery Wall Thickness in Obese and Nonobese Adults With Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatment

Abstract: Regardless of obesity status, carotid IMT is not increased in adults with moderate to severe OSA versus controls and does not change following 4 months of PAP treatment.

Cited by 20 publications

References 32 publications

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Sleep duration and 24‐hour ambulatory blood pressure in adults not on antihypertensive medications

Assessment of atherosclerotic plaque activity in patients with sleep apnea using hybrid positron emission tomography/magnetic resonance imaging (PET/MRI): a feasibility study

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