Carotid artery stenting

Roffi, Marco; Kulcsár, Zsolt; Carrera, Emmanuel; Cremonesi, Alberto

doi:10.1136/heartjnl-2015-307638

Cited by 5 publications

(3 citation statements)

References 37 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current generation carotid stents typically incorporate an open or closed-cell design. Open-cell stents have better conformability and wall apposition but their larger pore size reduces plaque coverage and allows a higher risk of debris extrusion [10]. Recent imaging capabilities, such as Optical Coherence Tomography (OCT) have played an important role in identifying the plaque prolapse [11].…”

Section: Introductionmentioning

confidence: 99%

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Shayan

Jankowitz

Shridhar

et al. 2016

JFB

View full text Add to dashboard Cite

Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70%–96% during 30 min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance, specifically on the diamond-shape M-TFN, with the dimensions of 145 µm × 20 µm and a porosity of 32%. Future studies will require in vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting.

show abstract

Section: Introductionmentioning

confidence: 99%

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Shayan

Jankowitz

Shridhar

et al. 2016

JFB

View full text Add to dashboard Cite

show abstract

“…1 We recently reviewed outcomes after >1 500 000 procedures in 21 administrative dataset registries where procedural death/stroke rates were reported for both CEA and CAS. 2 One key finding was that CAS was associated with in-hospital/ 30-day death/stroke rates that exceeded the 3% American Heart Association (AHA) risk threshold for asymptomatic patients in 9/21 registries (43%).…”

mentioning

confidence: 99%

Carotid artery stenting outcomes in dataset registries: a cause of concern or an opportunity for improvement?

Paraskevas

Naylor

2016

Heart

View full text Add to dashboard Cite

“…The current generation carotid stents typically incorporate an open or closed-cell design. Open-cell stents have better conformability and wall apposition but their larger pore size reduces plaque coverage and allows a higher risk of debris extrusion [10]. Recent imaging capabilities like Optical Coherence Tomography (OCT) have played an important role in identifying the plaque prolapse [11].…”

Section: Introductionmentioning

confidence: 99%

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Shayan¹,

Jankowitz²,

Shridhar³

et al. 2016

Preprint

View full text Add to dashboard Cite

Abstract:Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70-96% during 30min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance specifically on the diamond-shape M-TFN with the dimensions of 145µm×20µm and a porosity of 32%. Future studies will require in-vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting.

show abstract

Carotid artery stenting

Cited by 5 publications

References 37 publications

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Carotid artery stenting outcomes in dataset registries: a cause of concern or an opportunity for improvement?

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Contact Info

Product

Resources

About