Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Shayan, Mahdis; Jankowitz, Brian T.; Shridhar, Puneeth; Chun, Youngjae

doi:10.3390/jfb7040034

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…However, the further growth of cell populations proceeds better on smoother surfaces (of the LP series). This can be explained by easier cell motion over short distances on a smoother surface in The obtained results are in good agreement with study [52], where the dynamics of the interaction of cell populations with the surface of an alloy based on TiNi was considered. This study showed that implantable devices with a microroughness of 20-145 µm could successfully resist embolism.…”

Section: Cell Growth Experimentssupporting

confidence: 87%

Combined Porous-Monolithic TiNi Materials Surface-Modified with Electron Beam for New-Generation Rib Endoprostheses

Shabalina

Аникеев

Kulinich

et al. 2023

JFB

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TiNi alloys are very widely used materials in implant fabrication. When applied in rib replacement, they are required to be manufactured as combined porous-monolithic structures, ideally with a thin, porous part well-adhered to its monolithic substrate. Additionally, good biocompatibility, high corrosion resistance and mechanical durability are also highly demanded. So far, all these parameters have not been achieved in one material, which is why an active search in the field is still underway. In the present study, we prepared new porous-monolithic TiNi materials by sintering a TiNi powder (0–100 µm) on monolithic TiNi plates, followed by surface modification with a high-current pulsed electron beam. The obtained materials were evaluated by a set of surface and phase analysis methods, after which their corrosion resistance and biocompatibility (hemolysis, cytotoxicity, and cell viability) were evaluated. Finally, cell growth tests were conducted. In comparison with flat TiNi monoliths, the newly developed materials were found to have better corrosion resistance, also demonstrating good biocompatibility and potential for cell growth on their surface. Thus, the newly developed porous-on-monolith TiNi materials with different surface porosity and morphology showed promise as potential new-generation implants for use in rib endoprostheses.

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Section: Cell Growth Experimentssupporting

confidence: 87%

Combined Porous-Monolithic TiNi Materials Surface-Modified with Electron Beam for New-Generation Rib Endoprostheses

Shabalina

Аникеев

Kulinich

et al. 2023

JFB

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“…Stents are metallic tubular scaffolds or meshes that restore blood flow to the surrounding tissues by unblocking diverse blood vessels such as coronary, iliac, carotid, aorta, and femoral arteries. [48][49][50][51][52][53][54][55][56][57][58] Self-expanding NiTi and stainless-steel stents are frequently used to treat atherosclerotic vessels. NiTi stents' advantage over stainless steel ones is that they do not require balloon dilation, which risks more damage to the vascular tissue due to elastic recoil and dissection (Figure 2B-i).…”

Section: Medical Applications Of Smps and Smasmentioning

confidence: 99%

Smart Biomaterials in Biomedical Applications: Current Advances and Possible Future Directions

Cecen,

Hassan,

et al. 2023

Macromolecular Bioscience

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Smart biomaterials with the capacity to alter their properties in response to an outside stimulus or from within the environment around them have picked up significant attention in the biomedical community. This is primarily due to the interest in applications that may be anticipated from them in a considerable number of dynamic structures and devices. Shape‐memory materials are some of these materials that have been exclusively used for biomedical applications. They exhibit unique structural reconfiguration features they adapt as per the provided environmental conditions and can be designed for their enhanced biocompatibility. Numerous research has focused on these smart biocompatible materials over last few decades to enhance their biomedical applications. Shape‐memory materials play a significant role in biomedicine to meet new surgical and medical devices’ requirements for special features and utility cases. Because of the favorable design variety, different biomedical shape‐memory materials can be developed by modifying their chemical and physical behaviors to accommodate the desired requirements. In this review, we describe recent advances and characteristics of smart biomaterials for biomedical applications. We also discuss their clinical translations in tissue engineering, drug delivery, and medical devices.This article is protected by copyright. All rights reserved

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“…Subsequently, the sacrificial material and etchants/solvent 16 , are chosen such that the sacrificial material can be selectively etched/dissolved without damaging the main structure. Copper (Cu) as a sacrificial material, in the lift-off process, has been used for fabrication of nitinol microelectromechanical systems (MEMS) 17 , and micropatterned thin films 18 , 19 . The latter two reports 18 , 19 investigated the use of Cu as a sacrificial layer for fabrication of thin and thick film patterned NiTi.…”

Section: Introductionmentioning

confidence: 99%

“…Copper (Cu) as a sacrificial material, in the lift-off process, has been used for fabrication of nitinol microelectromechanical systems (MEMS) 17 , and micropatterned thin films 18 , 19 . The latter two reports 18 , 19 investigated the use of Cu as a sacrificial layer for fabrication of thin and thick film patterned NiTi. Such patterned NiTi films were also suggested 19 to be used as an additional layer in covering stents.…”

Section: Introductionmentioning

confidence: 99%

“…The latter two reports 18 , 19 investigated the use of Cu as a sacrificial layer for fabrication of thin and thick film patterned NiTi. Such patterned NiTi films were also suggested 19 to be used as an additional layer in covering stents. Another example of this lift-off process is fabrication of thin film NiTi thermostat arrays deposited on sacrificial Cu and chromium (Cr) layers 20 .…”

Section: Introductionmentioning

confidence: 99%

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Low-cost prototyping of nitinol wires/frames using polymeric cores and sacrificial fixtures with application in individualized frames anchoring through the atrial septum

Dulal,

Swan,

Al’Aref

et al. 2023

Sci Rep

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Self-expanding frames for minimally invasive implants are typically made from nitinol wires and are heat treated to maintain the desired shapes. In the process of heat treatment, nitinol structures are placed in a high-temperature oven, while they are confined by a fixture. During this process, nitinol exerts a high amount of force. Accordingly, a fixture requires high mechanical strength and temperature resistance; this is why fixtures are typically made from metals. The use of metal fixture also increases the turnaround time and cost. However, accelerating this process is beneficial in many applications, such as rapid development of medical implants that are patient-specific. Inspired by the use of sacrificial layers in microfabrication technology, here we propose a novel method for shape setting nitinol wires using a sacrificial metal fixture. In this process, the nitinol wires are first aligned inside copper hypotubes. Next, the forming process is done using hand-held tools to shape complex geometrical structures, annealing the nitinol reinforced by copper, and then selectively etching copper hypotubes in ammonium persulfate solutions. In this process, other sacrificial cores, which are 3D printed or cast from low-cost polymers, are also used. This combination of polymeric cores and minimal use of metals enables reducing the cost and the turnaround time. As a proof of concept, we showed that this process was capable of fabricating springs with mm or sub-mm diameters. The result showed a change of less than 5% in the intended diameter of the nitinol spring with diameters ranging from ~ 0.7 to 1.9 mm, which confirms copper as a suitable sacrificial fixture to obtain the desired complex geometry for nitinol. A metric, based on the elastic strain stored in copper is suggested to predict the possible variation of the intended dimensions in this process. Finally, to demonstrate the potential of this method, as proof of concept, we fabricated NiTi wire frames designed for anchoring through the atrial septum. These frames demonstrated septal defect occluders that were designed based on a patient’s cardiac image available in the public domain. This low-cost rapid fabrication technique is highly beneficial for a variety of applications in engineering and medicine with specific applications in rapid prototyping of medical implants.

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Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Cited by 4 publications

References 35 publications

Combined Porous-Monolithic TiNi Materials Surface-Modified with Electron Beam for New-Generation Rib Endoprostheses

Combined Porous-Monolithic TiNi Materials Surface-Modified with Electron Beam for New-Generation Rib Endoprostheses

Smart Biomaterials in Biomedical Applications: Current Advances and Possible Future Directions

Low-cost prototyping of nitinol wires/frames using polymeric cores and sacrificial fixtures with application in individualized frames anchoring through the atrial septum

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