Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

Taivainen, S. Helena; Laitinen, Tiina M; Yli-Ollila, Heikki; Juonala, Markus; Kähönen, Mika; Raitakari, Olli T.; Laitinen, Tomi

doi:10.1111/cpf.12687

Cited by 3 publications

(1 citation statement)

References 40 publications

(67 reference statements)

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“…The different patterns raise the question of whether the longitudinal motion might prove a valuable marker for future risk of cardiovascular disease Cinthio et al, 2006;Yli-Ollila et al, 2013;Zahnd et al, 2015;Zahnd, Boussel, Marion, et al, 2011). That this might be the case is supported by recent studies (Taivainen et al, 2017(Taivainen et al, , 2018(Taivainen et al, , 2021. Furthermore, previous studies have reported that the amplitude of the longitudinal displacement of the arterial wall is reduced in patients with carotid plaques, suspected coronary artery disease, Type 2 diabetes Zahnd, Boussel, Marion, et al, 2011), and periodontal disease (Zahnd et al, 2012).…”

Section: Introductionmentioning

confidence: 89%

The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study

Sjöstrand

Widerstrom

Svensson

et al. 2023

Physiological Reports

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Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in-between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82-0.96; p < 1e-3; k = 9.3-14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo.

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Section: Introductionmentioning

confidence: 89%

The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study

Sjöstrand

Widerstrom

Svensson

et al. 2023

Physiological Reports

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The influence of physical activity and sex on carotid artery longitudinal wall motion in younger healthy adults

Bryans,

Gopaul,

Athaide

et al. 2024

Appl. Physiol. Nutr. Metab.

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Carotid artery longitudinal wall motion (CALM) is a novel preclinical marker for atherosclerosis which describes the axial anterograde and retrograde motion of the intima-media complex. While regular physical activity and sex are known to independently influence arterial stiffness, their roles on axial arterial wall behaviour are unknown. The purpose of this study is to examine whether physical activity and sex impact CALM. We hypothesized that CALM retrograde displacement and total amplitude would be greater in females and active individuals, as a function of arterial stiffness. Fifty-seven young healthy adults (30 female; aged 22±3 years) were evaluated for CALM outcomes and arterial stiffness and grouped by physical activity based on active (V̇O2 = 44.2±8.9 mL/kg/min) or sedentary (V̇O2 = 33.7±6.7 mL/kg/min) lifestyles defined by the Canadian 24-hour movement guidelines. Arterial stiffness and CALM were measured by carotid-femoral pulse wave velocity (cfPWV) and vascular ultrasound at the right CCA with speckle tracking analysis, respectively. cfPWV was greater in males (p<0.01) with no interaction between sex and physical activity (p=0.90). CALM anterograde displacement was greater in males (p=0.03) resulting in a forward shift in total CALM pattern, which became less prominent when controlling for MAP (p=0.06). All other CALM outcomes were not different between activity or sex. V̇O2max was not correlated to any CALM outcome (all p>0.05). Apparent sex differences in vascular function extend to novel CALM outcomes but may be confounded by blood pressure. We recommend sex-balanced design and reporting in future studies due to possible anterograde-shifted CALM patterns in healthy males.

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Triglyceride-glucose index and cervical vascular function: outpatient-based cohort study

Pan,

Yue,

Ren

et al. 2023

BMC Endocr Disord

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Objectives The purpose of this study was to investigate the correlation between triglyceride-glucose (TyG) index and cervical vascular function parameters in the general population without cerebrovascular disease. Materials and Methods This was a cross-sectional study that recruited a total of 1996 participants without cerebrovascular disease. TyG index was calculated based on fasting triglycerides and glucose. All patients were divided into two groups based on the median TyG index: the high TyG group and the low TyG group. The differences in basic clinical characteristics and neck vascular function parameters between the two groups of participants were compared, and then the correlation between TyG index and neck vascular function parameters was investigated. Results Participants with a high TyG index had lower systolic, diastolic, and mean flow velocities in the basilar, vertebral, and internal carotid arteries compared with those with a low TyG index. Participants with a high TyG index had higher pulsatility index in the left vertebral artery and right internal carotid artery, but this difference was not observed in the basilar artery. In addition, TyG index was significantly negatively correlated with systolic, diastolic, and mean flow velocities in the basilar, vertebral, and internal carotid arteries, and the correlation remained after adjusting for confounding factors. Conclusion In the general population, there was a well-defined correlation between TyG index and cervical vascular function parameters, and increased TyG index was independently associated with reduced cervical vascular blood flow velocity.

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Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

Cited by 3 publications

References 40 publications

The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study

The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study

The influence of physical activity and sex on carotid artery longitudinal wall motion in younger healthy adults

Triglyceride-glucose index and cervical vascular function: outpatient-based cohort study

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