Carotid Artery Disease in NIDDM Diabetes

Abstract

A prospective study of 135 controls, 286 non-insulin-dependent diabetic patients, and 31 subjects with an elevated fasting plasma glucose was performed to assess the prevalence of high-grade carotid artery stenosis. The carotid artery evaluation was performed using an ultrasonic duplex scanner. When those patients with an elevated fasting plasma glucose and non-insulin-dependent diabetes were considered together, the prevalence was 8.2% as compared with 0.7% for the controls (P = 0.0007). Those risk factors found to be significantly related to the higher prevalence of carotid disease in the combined groups of patients included age, ratio of systolic blood pressure to diastolic blood pressure, plasma cholesterol, and cigarette smoking. These findings may be an explanation for the greater incidence of stroke in patients with diabetes mellitus.

Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn Study

“…To our knowledge, this is the first populationbased survey to determine the prevalence of CAS in NGT, IGT, NDM and KDM subjects in one cohort. One previous study reported a prevalence of 7.9 % [18] of any severe CAS in NIDDM subjects treated with sulphonylurea or insulin, which is similar to our results (7.6 %). In recently diagnosed NIDDM subjects a prevalence of 4.4 % (95 % CI: 1.2-11.3 %) for any severe CAS was reported [19].…”

“…In only a few studies, was the prevalence of CAS determined in subjects with non-insulin-dependent diabetes mellitus (NIDDM) [18,19]. To date, very few studies have included the total range of blood glucose level and reported its association with CAS in a population-based sample.…”

“…To study asymptomatic carotid artery disease, combined echo-Doppler (duplex) examination has been used in many epidemiological and clinical studies [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In the Hoorn Study, the evaluation of the duplex flow velocity curves was chosen as the non-invasive test to diagnose CAS, as it is easily and quickly performed without discomfort for the participant and can accurately be scored on-line.…”

Ophthalmic artery blood flow velocity changes in diabetic patients as a manifestation of macroangiopathy

“…The latter is characterized by ischemic heart, cerebrovascular and peripheral vascular diseases (Chait & Bierman 1994). Diabetic patients have a higher incidence of atherosclerosis involving the carotid artery (Chan et al 1983;Kawamori et al 1992). Diabetes aggravates carotid occlusive disease, which can manifest with ocular ischemic syndrome (OIS) (Sivalingam et al 1989;Mizener et al 1997;Ino-ue et al 1999).…”

Prevalence of extracranial carotid artery disease detectable by echo-Doppler in an elderly population.

“…In most instances these series included symptomatic vascular disease, with signs of coronary or peripheral ischemia 4 13 Less information is available on unselected free-living individuals, 14 especially if they are elderly.…”