Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn Study

Beks, P. H. J.; Mackaay, A. J. C.; Vries, H. de; Neeling, J.N.D. de; Bouter, Lex M.; Heine, R.J.

doi:10.1007/s001250050676

Cited by 51 publications

(32 citation statements)

References 39 publications

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“…Peripheral arterial disease was defined as self-reported peripheral arterial reconstruction, nontraumatic limb amputation, and/or an ankle brachial pressure index Ͻ0.50 (18). Cerebrovascular disease was defined as self-reported history of stroke or carotid stenosis Ͼ80% (19,20).…”

Section: Baseline Examinationmentioning

confidence: 99%

Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease

et al. 2001

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OBJECTIVE -Measures of baroreflex sensitivity, heart rate variability (HRV), and the classical Ewing test parameters are currently used for the diagnosis of diabetic autonomic neuropathy and for mortality risk stratification after myocardial infarction. However, the strengths of the associations of these measures of autonomic function with risk of mortality have never been compared in one study population. Furthermore, no evidence is available on the possible effect of glucose tolerance on these associations. RESEARCH DESIGN AND METHODS-The study population (n ϭ 605) consisted of a glucose tolerance-stratified sample from a general population (50 -75 years of age). Cardiac cycle duration and continuous finger arterial pressure were measured under two conditions: at rest and on metronome breathing. From these readings, seven parameters of autonomic function were assessed (one Ewing, five HRV, and one baroreflex sensitivity).RESULTS -During 9 years of follow-up, 101 individuals died, 43 from cardiovascular causes. Subjects with diabetes and low levels of the autonomic function parameters, indicating impaired autonomic function, had an approximately doubled risk of mortality. This association was consistent, though not statistically significant, for all parameters. The elevated risk was not observed in subjects without diabetes, hypertension, or prevalent cardiovascular disease.CONCLUSIONS -Impaired autonomic function is associated with all-cause and cardiovascular mortality. Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous.

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Section: Baseline Examinationmentioning

confidence: 99%

Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease

et al. 2001

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“…The study population consisted of an age-, sex-, and glucose-tolerance-strati®ed sample of the Hoorn Study, a population-based study of glucose tolerance and other cardiovascular risk factors in a 50-to 75-year-old general Caucasian population conducted from 1989±1992, as described previously [16].…”

Section: Subjectsmentioning

confidence: 99%

“…Subjects were classi®ed as current cigarette smokers or nonsmokers. Body mass index (BMI) and waist-to-hip ratio (WHR) were calculated as described elsewhere [16]. ABO blood groups were determined by standard agglutination techniques using commercial test erythrocytes.…”

Section: Laboratory and Clinical Assessmentsmentioning

confidence: 99%

“…The latter is important because diabetes and tHcy seem to interact [3]. Therefore, we assessed, in a population-based study that was strati®ed for glucose tolerance [16], the association between tHcy level and endothelial dysfunction by measuring plasma levels of the endothelium-derived regulatory protein, von Willebrand factor (vWf). We also assessed the association between tHcy and the soluble form of vascular cell adhesion molecule 1 (sVCAM-1) as an estimate of the adherence and transendothelial migration of leukocytes; and ®nally, between tHcy and C-reactive protein, a marker of chronic low-grade in¯ammation.…”

Section: Introductionmentioning

confidence: 99%

“…These subjects underwent a second OGTT (except those who already used blood glucose lowering agents; n 67). On the basis of the mean of the two OGTTs, glucose tolerance was divided into three categories [16]: normal glucose tolerance (n 288), impaired glucose tolerance (n 170) and type 2 diabetes (n 173). Subjects with normal or impaired glucose tolerance or type 2 diabetes in the present study population thus represented a strati®ed random sample of all subjects with normal or impaired glucose tolerance or type 2 diabetes in the initial cohort.…”

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confidence: 99%

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Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Becker

Hinsbergh

Kostense

et al. 2000

Eur J Clin Investigation

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Background Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was ®rstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade in¯ammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively. Secondly we investigated whether the presence of type 2 diabetes modi®es these associations.

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Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance

Chiasson

Josse²,

Gomis³

et al. 2003

JAMA

1,523

886

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Context The worldwide explosive increase in type 2 diabetes mellitus and its cardiovascular morbidity are becoming major health concerns. Objective To evaluate the effect of decreasing postprandial hyperglycemia with acarbose, an ␣-glucosidase inhibitor, on the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance (IGT). Design, Setting, and Participants International, multicenter double-blind, placebocontrolled, randomized trial, undertaken in hospitals in Canada,

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Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn Study

Cited by 51 publications

References 39 publications

Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease

Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance

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