Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy

Li, Qiliang; Song, Wenqi; Hong, Jing

doi:10.1007/s13312-018-1322-4

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Several mechanisms have been proposed for valproate-induced hepatotoxicity, including reactive metabolites of valproate [8,9]. In addition, the involvement of carnitine deficiency [10,11], hyperammonemia [5], and oxidative stress or enhanced production of ROS has been reported [3,12]. This is supported by our findings showing that there was a considerable increase in serum ALT levels in the sodium valproate group compared with the vehicle group but not in serum AST levels (data not shown).…”

Section: Discussionsupporting

confidence: 73%

Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

et al. 2020

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Aim: This study examines the effect of alpha-lipoic acid (ALA) on sodium valproate-induced liver injury through histological features of mice liver tissue. Materials and Methods: Mice were divided into three groups; (1) vehicle group, (2) sodium valproate group, and (3) sodium valproate-ALA group. The vehicle group was injected with saline intraperitoneal (i.p.) for 28 days. The sodium valproate group was injected with sodium valproate 300 mg/kg, i.p. daily for 2 weeks, after which the vehicle was administered daily until day 28. The sodium valproate-ALA group was injected with sodium valproate 300 mg/kg daily for 2 weeks before the administration of ALA 100 mg/kg i.p. until day 28. The mice were euthanized, and the liver was extracted for histopathological examination. Results: Histopathological examination of the liver section of the vehicle group showed a normal structure of the liver. Two weeks after the administration of sodium valproate, histopathological examination showed an abnormal structure of the liver, with necrotic appearance and inflammatory cells. Moreover, treatment with ALA after the administration of sodium valproate notably ameliorated hepatic histopathological lesions and the liver structure corresponded to a normal liver structure. Conclusion: ALA ameliorates sodium valproate-induced liver injury in mice.

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Section: Discussionsupporting

confidence: 73%

Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

et al. 2020

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“…Current study showed also that L-carnitine was more protective than NAC and this could be explained by the fact that VPA administration was associated with deficiency of serum carnitine levels as mentioned by Qiliang et al, (2018). This deficiency concept was proven in the present study by administration of Lcarnitine in addition to its antioxidant and enhancing its role on the male reproductive system more than NAC.…”

Section: Discussionsupporting

confidence: 64%

Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats

Said

Yassin

Mohammad

et al. 2023

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: Sodium valproate (VPA) is a well-known antiepileptic drug used in treatment of generalized seizures and cause many toxic effects. Aim: This study aimed to highlight the VPA effects on testes in adult male albino rats and protective effect of N-acetyl cysteine (NAC) and L-carnitine. Methodology: Sixty adult male albino rats divided into six groups randomly, 10 rats each, group I: negative control group not received any treatment. group II: positive control group received NAC 150 mg/kg/day orally, group III: positive control group received Lcarnitine 500 mg/kg/day orally, group IV: received VPA 400 mg/kg/day orally which equals 40/67 of Ld50 of valproic acid in rats, group V: received VPA 400 mg/kg and NAC 150 mg/kg daily orally, group VI: received VPA 400 mg/kg and L-carnitine 500 mg/kg daily orally for 45 days. Results: This study revealed high significant difference between group received VPA (IV) in form of marked decrease in serum testosterone compared to control groups (I, II, III), laboratory parameters are co-incident with histopathological findings in testes of these groups. We found a significant improvement in laboratory parameters in the form of higher serum testosterone levels in groups received antioxidants with VPA (V, VI), co-incident with histopathological findings in testes of these groups, with a higher protective power of Lcarnitine than N-acetyl cysteine. Conclusion: Sodium valproate induces testicular toxicity in high doses (400 mg/kg) in male albino rats. There is a protective role for both NAC and Lcarnitine. L-carnitine exhibited more protective effect than NAC on their administration with VPA.

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