Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome

Jamilian, Mehri; Foroozanfard, Fatemeh; Kavossian, Elham; Aghadavod, Esmat; Amirani, Elaheh; Mahdavinia, Mostafa; Mafi, Alireza; Asemi, Zatollah

doi:10.1080/0167482x.2018.1557144

Cited by 19 publications

(23 citation statements)

References 60 publications

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“…In seven trials [22,32,36,39,41,45,47] and one effect size [23] (a) a dosage ≥ 500-1000 mg was administrated. A dosage ≥ 1000-2000 mg was provided in 12 studies [12,19,20,26,27,31,42,43,46,50,53,54] and one effect size [25] (a). A dosage ≥ 2000 mg was reported in 13 studies [14, 18, 24, 28-30, 33, 37, 40, 44, 49, 51, 55], and 2 effect sizes [23] (b) and [25] (b).…”

Section: Resultsmentioning

confidence: 99%

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

Fathizadeh

Milajerdi

Reiner

et al. 2020

J Diabetes Metab Disord

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Objective Several trials investigated the efficacy of L-carnitine administration on markers of inflammation and indicators of oxidative stress; however, their findings are controversial. The aim of this study was to conduct a comprehensive meta-analysis and a critical review, which would analyze all randomized controlled trials (RCTs) in order to determine the effects of L-carnitine supplementation on inflammatory markers and oxidative stress. Methods An electronic search was performed using Scopus, Cochrane Library, PubMed, Google scholar and Web of Science databases on publications from 1990 up to May 2020. Human RCTs conducted in healthy subjects or participants with certain disorders which investigating the efficacy of L-carnitine supplementation compared to control (placebo, usual treatment or no intervention) on inflammation and oxidative markers were included. Data were pooled applying a random-effects model and as the overall effect size, weighted mean difference (WMD) was presented. Between heterogeneity among studies was computed using Cochran's Q test and I-square (I 2 ). Quality of studies assessed using the Jadad scale. Dose-response analysis was measured using meta-regression. The funnel plot, as well as the Egger's regression test was applied to determine the publication bias. Results 44 trials (reported 49 effect sizes for different outcomes of interest) met the inclusion criteria for this meta-analysis. According to the findings, L-carnitine supplementation resulted in a significant reduction in C-reactive protein (CRP) (WMD: -0.10; 95%

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Section: Resultsmentioning

confidence: 99%

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

Fathizadeh

Milajerdi

Reiner

et al. 2020

J Diabetes Metab Disord

Self Cite

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“…Majority of these diseases have been associated with high incidence rates of psychological distress. Other clinical studies have found that chronic inflammatory factors, such as ILs, TNFα, PAI-1, and MCF-1, are increased in the peripheral blood of patients with PCOS to varying degrees [15].…”

Section: Introductionmentioning

confidence: 92%

Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study

Guo

Shan

et al. 2020

Mediators of Inflammation

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Objective. This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. Methods. Seventy-five patients with PCOS comorbid psychological distress were randomly allocated into the PM, metformin, and placebo groups. The primary efficacy measure was the change from baseline to week 12 on the Symptom Checklist 90-R (SCL-90-R) scores. NLRP3 inflammasome, IL-1β, IL-6, TNF-α, and biochemical parameters were determined at baseline and at week 12. The participants were required to meet the criteria for PCOS (Rotterdam, NIH) and psychological distress (any factor scores of SCL−90−R>2). Results. The participants had significantly high scores on the SCL-90-R scales of anxiety and depression. PM significantly decreased anxiety and depression symptom severity (from 2.31±0.75 to 1.65±0.38, p<0.001, and from 2.08±0.74 to 1.61±0.46, p=0.010, at week 12, respectively). PM significantly decreased the expression of NRPL3 and caspase-1. Patients in the PM group experienced a significant reduction in IL-1β (from 98.42±14.38 to 71.76±13.66, p=0.02), IL-6 (from 87.51±8.74 to 71.98±15.87, p=0.02), and TNF-α (from 395.33±88.55 to 281.98±85.69, p=0.04). PM was superior to metformin in reducing total testosterone (2.24±0.74 versus 3.06±0.83, p=0.024, at week 12).Conclusions. This study is the first to reveal that PM alleviates psychological distress via inhibiting NLRP3 inflammasome and improves several markers, including total testosterone.

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“…Some Lactobacillus may play an important role in improving PCOS by regulating and controlling the sex hormone-related microorganisms. Melatonin [148] has certain effects on reducing oxidative stress, and acts as an antioxidant, anti-inflammatory, and antidepressant agent; fish oil [149] can significantly improve the expression of PPAR -c, IL-1, and IL-8 genes related to PCOS; omega-3 fatty acids [149] can reduce C-reactive protein and increase adiponectin levels to reduce the inflammatory state of women with PCOS; after providing PCOS patients with vitamin D deficiency supplements including calcium, vitamin D, and K for 8 weeks, insulin metabolism, serum triglyceride, and very low-density lipoprotein cholesterol levels were improved [150]; combining the use of carnitine with chromium [151] can improve the mental health indicators, serum total T, high-sensitivity C-reactive protein, Total Antioxidant Capacity (TAC), and Malondialdehyde (MDA) levels of women with PCOS, as well as the gene expression of Interleukin-6 (IL-6) and Tumor Necrosis Factor alpha (TNF -α); selenium (SE) [152] is a kind of antioxidant and has an insulin-like effect. All of the drugs listed above may have a therapeutic effect on PCOS and provide new direction for the treatment of PCOS.…”

Section: Complementary Alternative Medicinementioning

confidence: 99%

The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome

Zhang

Guo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovary syndrome (PCOS) is a frequent gynecological female endocrinopathy, characterized by chronic anovulation, hyperandrogenism, and insulin resistance (IR). Menstrual disorders are one of the main clinical manifestations of PCOS. Other symptoms include hirsutism and/acne. At present, the treatment of PCOS with irregular menstruation is mainly based on oral contraceptives, but there are some side effects and adverse reactions. In recent years, more and more attention has been paid to the complementary and alternative medicine (CAM), which has been widely used in clinical practice. Modern Western medicine is called “conventional medicine” or “orthodox medicine,” and the complementary and alternative medicine is called “unconventional medicine” or “unorthodox medicine.” CAM includes traditional medicine and folk therapy around the world. Around 65–80% of world health management business is classified into traditional medicine by the World Health Organization, which is used as alternative medicine in Western countries. In our country, Chinese medicine, acupuncture, and other therapies are commonly used due to their significant efficacy and higher safety. Therefore, this review aims to summarize and evaluate the mechanisms and the effect of current complementary replacement therapy in the treatment of menstrual disorders caused by PCOS, so as to provide guidance for the following basic and clinical research.

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Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome

Cited by 19 publications

References 60 publications

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study

The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome

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