2020
DOI: 10.1007/s40200-020-00627-9
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Abstract: Objective Several trials investigated the efficacy of L-carnitine administration on markers of inflammation and indicators of oxidative stress; however, their findings are controversial. The aim of this study was to conduct a comprehensive meta-analysis and a critical review, which would analyze all randomized controlled trials (RCTs) in order to determine the effects of L-carnitine supplementation on inflammatory markers and oxidative stress. Methods An electronic search was performed using Scopus, Cochrane L… Show more

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Cited by 30 publications
(29 citation statements)
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“…It is known that ACE2 levels in lungs and plasma are higher under inflammatory conditions [ 34 ], thus increasing the susceptibility of cells from the population suffering from the above conditions to SARS-CoV-2 infection. L-carnitine has been reported to play a regulatory role in inflammatory processes [ 22 , 23 , 38 ], and L-carnitine supplementation has beneficial effects in populations with relatively low L-carnitine levels, such as that which occurs in the elderly and in a variety of inflammatory disease states [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
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“…It is known that ACE2 levels in lungs and plasma are higher under inflammatory conditions [ 34 ], thus increasing the susceptibility of cells from the population suffering from the above conditions to SARS-CoV-2 infection. L-carnitine has been reported to play a regulatory role in inflammatory processes [ 22 , 23 , 38 ], and L-carnitine supplementation has beneficial effects in populations with relatively low L-carnitine levels, such as that which occurs in the elderly and in a variety of inflammatory disease states [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…L-carnitine’s basic role is to transport fatty acids to the mitochondrial matrix, making them available for beta-oxidation and energy generation through the Krebs cycle [ 21 ]. It is also a powerful anti-oxidant and anti-inflammatory mediator [ 22 , 23 ]. At the tissue level, L-carnitine accumulates mainly in the muscle, heart, and lung tissues [ 24 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Moreover, in acute conditions, such as in myocardial infarction, LC could mitigate abnormal oxidative stress condition and enhance cardiomyocytes survival. Animal studies and preliminary clinical studies seem to confirm this hypothesis [195][196][197][198]. It is important to note that these first trials suggest that LC improves antioxidative cellular defense, in particular the NRF2 pathway [198].…”
Section: From Caloric Restriction To Cr-related Nutrients: L-carnitinementioning
confidence: 78%
“…↓ serum inflammatory mediators ↑ superoxide dismutase level ↓ inflammatory cytokines ↑ antioxidant mitochondrial enzymes Fathizadeh et al [197] Human study Heart: ↓ NF-κB signaling pathway ↑ Nrf2 levels ↓ inflammatory cytokines ↑ antioxidant mitochondrial enzymes Li et al [198] In vivo (diabetic rats) Skeletal muscle: ↑ anti-oxidative factors ↑ insulin sensitivity index ↑ metabolic profile ↑ contractile properties Samir et al [199] In vivo (NAFLD model mice)…”
Section: Type Of Studies Tissue Molecular Mechanisms Effects Referencesmentioning
confidence: 99%