Caries: Review of Human Genetics Research

Vieira, Alexandre R.; Modesto, Adriana; Marazita, Mary L.

doi:10.1159/000358333

Cited by 129 publications

(135 citation statements)

References 125 publications

(69 reference statements)

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“…Association between enamel (DS 1-2 ) and dentine (DS [3][4][5] ) caries A significant regression equation was found (F (1,1930) ¼ 195.34, p < .001) with an R 2 of 0.092. Participants' predicted number of surfaces with dentine caries was equal to 0.479 þ 0.103 enamel caries per dentine caries surface.…”

Section: Dental Caries Prevalencementioning

confidence: 95%

“…Caries on root surfaces was included in the registration of caries. Secondary caries was not included in the calculations of primary enamel and dentine caries, hereafter named DS [1][2][3][4][5] , due to the low reliability of caries grading in connection with dental restorations [18]. Prior to study start, all examiners were trained and calibrated towards the gold standard [19], regarding the diagnostic criteria and examination procedures including radiographic examination technique.…”

Section: Clinical and Radiographic Examinationmentioning

confidence: 99%

“…As there were multiple comparisons in the ANOVA test, a Bonferroni correction of significant levels was made to protect against type 1 errors. A simple linear regression was calculated to predict the number of surfaces with dentine caries (DS [3][4][5] ) based on the number of enamel caries (DS 1-2 ) lesions. In a binary logistic regression analysis, people with zero (0) initial or dentinal caries (DS 1-5 ) lesions were used as dependent variable (i.e.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Over 50% of the individuals in the youngest age group had a mean DS 1-5 value of 5 surfaces (Table 3). Figure 1 shows the Lorenz curves comparing all carious lesions (DS [1][2][3][4][5] ) between different age cohorts. Where the curve intersects with the Y-axis (X ¼ 100%) indicates the fractions of the population with and without caries, although in the latter group most people had restorations and also some teeth had been extracted due to caries.…”

Section: Primary Dental Caries Distribution (Ds 1-5 ) Versus (Ds 3-5 )mentioning

confidence: 99%

“…No single variable explains the variation among individuals. Factors that have been explored include diet [1,2], genetics [3,4] and socioeconomic status [5,6]. Sheiham and James [2] concluded that dental caries is a diet-mediated disease and that there is extensive scientific evidence that free sugars are the primary necessary factor.…”

Section: Introductionmentioning

confidence: 99%

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Is caries equally distributed in adults? A population-based cross-sectional study in Norway – the TOHNN-study

Oscarson

Espelid

Jönsson

2017

Acta Odontologica Scandinavica

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Objectives: The aim of the study was to examine the prevalence and distribution of dental caries in an adult population and identify factors associated with being caries free. Material and methods: Data were collected from a randomized population sample in Northern Norway (N ¼ 1932; 988 women; mean age 47.0 years, SD 15.3). The study included a structured questionnaire and a clinical examination. The sum of enamel and dentine caries, DS 1-5 , formed the main outcome measures for caries prevalence. Results: Mean DMFT was 15.1 (95% CI 14.8, 15.4), mean DFT was 12.0 (CI 11.7,12.2), and mean DT was 1.1 (CI 1.0, 1.2). The mean value for dentine caries (DS 3-5 ) was 0.8 (CI 0.7, 0.9), and mean DS 1-5 was 3.8 (CI 3.6, 4.1). Mean DS 1-5 was highest in the youngest age group (mean 6.9, 95% CI 6.3, 7.6) and in rural areas (mean 5.0, CI 4.4, 5.6). The most caries-prone 20% in the youngest age group had 52% of the total number of carious lesions compared with 80% in the two oldest age groups. Tooth brushing twice daily (p ¼ .005), drinking sugar containing soft drink (p ¼.029), and attending dental services every year (p < .001), were associated with being caries free. Conclusion: Dental caries is still a common condition, particularly in the youngest age group. Living in a rural area, low socioeconomic status, less frequent tooth cleaning and sugar containing soft drinks were associated with a higher prevalence of dental caries. The different caries distribution among adults calls for different preventive strategies at both population and individual levels. ARTICLE HISTORY

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Section: Dental Caries Prevalencementioning

confidence: 95%

Section: Clinical and Radiographic Examinationmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Primary Dental Caries Distribution (Ds 1-5 ) Versus (Ds 3-5 )mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is caries equally distributed in adults? A population-based cross-sectional study in Norway – the TOHNN-study

Oscarson

Espelid

Jönsson

2017

Acta Odontologica Scandinavica

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Genetic Influences on Dental Caries

Vieira

2016

Encyclopedia of Life Sciences

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Dental caries is the most common bacteria‐mediated disease in the world despite being highly preventable. It is traditionally described as the interplay among a susceptible host, microbiota and diet. While studies of environmental risk factors have dominated the research effort on cariology, the past decade has demonstrated a growing interest in the factors that are genetically controlled that directly affect the host. The dental enamel, saliva and immune responses and individual behaviours are such factors. Genes involved in dental enamel development have been in the centre of most recent investigations; however, genes related to immune responses and saliva formation appear to be growing in interest. Genetics of behaviour is still an area completely unexplored in the cariology field, with the exception of the known variants that influence individual taste preferences. New insight may come for exploring the genes that are involved in the decision‐making process. Key Concepts Dental caries is a bacteria‐mediated disease that is greatly influenced by factors of the host. Host factors influencing dental caries are genetically influenced. Our limited understanding of the genetic influences of the host has impaired our ability for preventing dental caries at the population level.

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Dental caries and other dental diseases

Lukacs

2018

The International Encyclopedia of Biological Anthropology

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Dental caries is an infectious disease resulting in the destruction of enamel and dentine by acids produced by bacteria. Caries are associated with other pathological dental lesions that may promote caries formation (enamel hypoplasia, periodontal disease), or occur subsequent to severe caries (exposure and infection of the pulp chamber, abscess cavity formation, and antemortem tooth loss). Anthropological interest in dental caries and associated dental diseases is motivated by the complex biological and cultural factors that influence their frequency and distribution in human populations. Mode of subsistence, biological and cultural components of sex, and differences in social status all have an impact on the distribution of dental diseases in prehistoric and living human populations.

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Caries: Review of Human Genetics Research

Cited by 129 publications

References 125 publications

Is caries equally distributed in adults? A population-based cross-sectional study in Norway – the TOHNN-study

Is caries equally distributed in adults? A population-based cross-sectional study in Norway – the TOHNN-study

Genetic Influences on Dental Caries

Dental caries and other dental diseases

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