Caries prevention by dentifrices containing a combination of sodium monofluorophosphate and sodium fluoride. Report of a 3-year clinical trial

Hodge, Harold C.; Holloway, P J; Davies, Tom; Worthington, Helen V

doi:10.1038/sj.bdj.4804492

Cited by 38 publications

(17 citation statements)

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“…Based on the observations from studies on enam el-fluoride kinetics [Feagin and Gray, 1977;ten Cate and Duijsters, 1983] it can be assumed that the cariostatic potential of F dentifrices are closely connected to the levels of salivary concentrations pro duced by these agents. However, conflict ing results have been reported from the few studies testing the relationship be tween the F levels in otherwise identically formulated dentifrices and their cariostat ic potential [Reed, 1973;Hodge et al, 1980;Barlage et al, 1981;Koch et al, 1982], Obviously, the improvement of the cariostatic effect of F-containing denti frices is not a simple matter of further em pirical addition of fluoride. Rather, fur ther development of effective F dentifrices should be based on profound knowledge of the interaction of fluoride with caries progression togeth er with information of the availability and behaviour of fluoride in the oral environ ment after toothbrushing.…”

Section: Discussionmentioning

confidence: 87%

Whole Saliva Fluoride after Toothbrushing with NaF and MFP Dentifrices with Different F Concentrations

Bruun

Givskov

Thylstrup³

1984

Caries Res

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The present study was designed to assess the effect of F compound and F concentration in dentifrices on fluoride in whole saliva after ordinary toothbrushing. The dentifrices tested had the same basic composition and contained NaF: 500, 1,000 or 1,500 ppm F or MFP: 1,000 or 1,500 ppm F. Whole saliva samples were collected at different times up to 120 min after brushing with controlled amounts of dentifrice. With all dentifrices tested, total F in whole saliva remained higher than controls for more than 60 min. Total F and F^–– levels showed a simple relationship to the F concentration in the dentifrices. The F^–– levels were initially significantly lower with the MFP than with comparable NaF preparations, but 10 min after brushing similar F^–– levels were observed with the two compounds. With the MFP dentifrices the proportion of F^–– to total F increased from 4% after 0.5 min to about 65% after 10 min indicating that MFP was subjected to rapid hydrolysis in the oral environment.

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Section: Discussionmentioning

confidence: 87%

Whole Saliva Fluoride after Toothbrushing with NaF and MFP Dentifrices with Different F Concentrations

Bruun

Givskov

Thylstrup³

1984

Caries Res

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“…Desses, nove deles utilizaram dentifrício a base de monofluorfosfato de sódio com concentrações entre 1.000-15.000 ppm. Dois estudos apresentaram o efeito na direção esperada, mas sem significância estatística (valor d= -0,09 IC 95% -0,29/+0,1) 15 (valor d= -0,06 IC 95% -0,17/+0,00), 5 sendo que um deles apresentou-se não homogêneo. 5 Todos os demais confirmaram a hipótese de que o dentifrício fluoretado é mais efetivo que o dentifrício sem flúor (valor d= -0,29 IC 95% -0,34/-0,24), variando entre um efeito de redução de 5% até 38%.…”

Section: Resultsunclassified

“…Tabela 5 -Estudos sobre a efetividade da incorporação de anti-microbianos ao dentifrício fluoretado na redução da cárie dental, tamanho do efeito, IC 95% e teste de homogeneidade. 15 que apresentou uma redução de apenas 9% (Tabela 6).…”

Section: Resultsunclassified

A efetividade do dentifrício fluoretado no controle da cárie dental: uma meta-análise

Chaves

Vieira-da-Silva

2002

Rev. Saúde Pública

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Resumo ObjetivoRealizar uma meta-análise sobre a efetividade da escovação com dentifrício fluoretado na redução da cárie dental para calcular o efeito das diferentes hipóteses testadas. Métodos Foram revisados artigos publicados sobre a efetividade da educação em saúde oral no período compreendido entre 1980 e 1998, indexados nas bases de dados Medline e Lilacs. Para avaliação da qualidade dos artigos, foram utilizados os critérios de rigor metodológico de Kay & Locker após serem submetidos a um comitê de experts formado por pesquisadores I-A do CNPq. Dos 43 artigos identificados, 22 (51,2%) atingiram os critérios de rigor metodológico propostos. O cálculo do tamanho do efeito da intervenção de cada estudo foi feito a partir das diferenças de resultados entre os grupos de teste e controle. O efeito global foi calculado para cada agrupamento de estudos segundo as hipóteses testadas. Resultados O aumento da concentração do flúor parece estar associado com o aumento do efeito (redução global = -0,17 IC 95% -0,22/-0,12). O maior percentual de redução de cárie foi verificado na comparação entre dentifrícios fluoretados e aqueles sem flúor (redução global = -0,29 IC 95% -0,34/-0,24). A adição de anti-microbianos (redução global = -0,03 IC 95% -0,07/+0,02), diferenças nos sistemas abrasivos (redução global = -0,02 IC 95% -0,09/+0,04) e diferenças nos princípios ativos não aumentam a efetividade dos mesmos (redução global = -0,04 IC 95% -0,10/+0,01). Conclusões As maiores reduções de cárie foram encontradas nos estudos com escovação supervisionada. A síntese confirmou a importância da escovação com dentifrício fluoretado no controle da cárie dental. Contudo, aponta para uma ênfase nos aspectos medicamentosos relacionados ao controle da doença, em detrimento de ações educativas específicas. A heterogeneidade de resultados indica que sejam considerados os contextos de implantação das práticas preventivas no processo de sua avaliação. Abstract ObjectiveTo carry out a meta-analysis on the effectiveness of fluoride toothpaste for reducing dental caries to calculate the effect size of different hypothesis.

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“…This assumption is sup ported by numerous clinical trials on topical fluoride regimens which show more protec tion to teeth erupted during the trial than to teeth already present at the time when the trial began \Rugg- Gunn et al, 1973;Down er et al. 1976;Howat et al, 1978;Hodge et al, 1980;Stookey, 1981]. Therefore, it is not surprising that populations exposed to long-term regular fluoride rinsing programs have exhibited greater caries reductions than those subjected to short-term clinical trials [Birkeland et al, 1977;Birkeland and Torell, 1978].…”

Section: Discussionmentioning

confidence: 99%

Caries Prevalence in Danish Children Living in Areas with Low and Optimal Levels of Natural Water Fluoride

Thylstrup¹,

Billé²,

Bruun³

1982

Caries Res

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Trends in caries prevalence 1972–1980 are presented from Danish school children 7–15 years of age living in two communities with about 0.4 and one with 1.5 parts/10⁶ F^- in the drinking water. In all three areas a Child Dental Health Service had been established in 1956–1957. Dental caries data were derived from the standardized recording system introduced in the Danish Child Dental Health Service in 1972. Over this period the F area showed a consistent low prevalence of caries. In the same period a gradual decline in caries was observed in the low F areas approaching the level in the F area. Thus, in 1980 the average DMF-S in all three areas fell within 1.0–1.2 and 10.8–11.4 DMF-S for children 7 and 15 years of age, respectively. Many factors may have contributed to the levelling out of differences in caries formerly observed between low and optimal F areas. Increased use of fluoride-containing dentifrice in Denmark and regularly fortnightly fluoride rinsing programs in the low F areas since 1967 may, however, provide the most reasonable explanation for the findings.

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Caries prevention by dentifrices containing a combination of sodium monofluorophosphate and sodium fluoride. Report of a 3-year clinical trial

Cited by 38 publications

References 0 publications

Whole Saliva Fluoride after Toothbrushing with NaF and MFP Dentifrices with Different F Concentrations

Whole Saliva Fluoride after Toothbrushing with NaF and MFP Dentifrices with Different F Concentrations

A efetividade do dentifrício fluoretado no controle da cárie dental: uma meta-análise

Caries Prevalence in Danish Children Living in Areas with Low and Optimal Levels of Natural Water Fluoride

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