Carence en vitamine B12, ataxie cérébelleuse et troubles cognitifs

Gochard, A.; Mondon, Karl; Toffol, Bertrand de; Autret, A

doi:10.1016/j.neurol.2008.12.004

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Because the cerebellum has less requirement for vitamin B12 and less storage, it is more likely to have cerebellar damage once vitamin B12 is deficient for a long time. [6,7] Studies have confirmed that long-term administration of mecobalamin (a vitamin B12 analogue) can protect rat cortical neurons from N-methyl-D-aspartate receptor-mediated neurotoxicity, [8] and can reduce the damage of neurotoxicity to mouse cerebellar granule cells. [9] In addition, vitamin B12 can also promote the growth of the neurite of mammalian cerebellar granule neurons.…”

Section: Discussionmentioning

confidence: 99%

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Zhu,

Yu,

et al. 2024

Medicine

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Rationale: Subacute combined degeneration of the spinal cord is a degenerative disease of the central and peripheral nervous systems caused by vitamin B12 deficiency, mainly involving the spinal cord posterior, lateral, and peripheral nerves, but rarely involving the cerebellum. Patient concerns: A 41-year-old woman presented with a 2-year history of walking unsteadily. Her hematologic examination revealed megaloblastic anemia and vitamin B12 deficiency. Electromyography showed multiple peripheral nerve damage (sensory fibers and motor fibers were involved). Imaging examination showed long T2 signal in the cervical, thoracic and lumbar spinal cord and cerebellum. Gastroscopy revealed autoimmune gastritis. Diagnoses: Subacute combined degeneration of the spinal cord. Interventions: By supplementing with vitamin B12. Outcomes: The patient’s symptoms of limb weakness, diet, and consciousness were improved, and the muscle strength of both lower limbs recovered to grade IV. Lessons: The symptomatic people should seek medical treatment in time to avoid further deterioration of the disease. When esophagogastroduodenoscopy is performed as part of routine physical examination in asymptomatic people, it should be checked for the presence of autoimmune gastritis. Early diagnosis can prevent irreversible neuropathy.

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Section: Discussionmentioning

confidence: 99%

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Zhu,

Yu,

et al. 2024

Medicine

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“…SACD is characterized by degeneration of the posterior and lateral columns of the spinal cord and clinically presents with sensory symptoms, ataxia and spastic paraparesis or tetraparesis. 2,3 MRI of the spine may show abnormal signal intensity in the dorsal column on T2-weighted images. 3 While it usually presents as a subacute to chronic myelopathy, this case illustrates that more acute presentations of myelopathic symptoms are also possible.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 MRI of the spine may show abnormal signal intensity in the dorsal column on T2-weighted images. 3 Although it usually presents as a subacute to chronic myelopathy, this case illustrates that more acute presentations of myelopathic symptoms are also possible.…”

Section: Discussionmentioning

confidence: 99%

Clinical Reasoning: An Unusual Case of Acute Psychosis and Tetraparesis in a Young Zambian Man

et al. 2021

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A 27-year-old Zambian man presented to the neurology clinic with a 1-month history of mental status changes and a 5-day history of visual and auditory hallucinations, paranoia, and difficulty walking. Notably, a month before presentation, he became increasingly withdrawn and was diagnosed with depression in a psychiatry clinic. His medical history was also significant for an anal fissure with hematochezia and severe anemia (hemoglobin 4 g/dL) 6 months prior. Examination revealed a thin patient responding to auditory and verbal hallucinations who accused the examiner of trying to harm him. He had a spastic tetraparesis with 2/5 power in all limbs, hyperreflexia with clonus, and a palpable bladder and was unable to walk. Sensory examination was unreliable because of the patient's mental state. Questions for Consideration:1. What is the localization for his presentation? 2. What is the differential diagnosis for the etiology of his presentation? GO TO SECTION 2

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“…La sclérose combinée de la moelle constitue l'atteinte classique du système nerveux central, mais elle est rarement observée ; cette affection associe un syndrome cordonal postérieur et un syndrome pyramidal déficitaire [2,14,33,54]. Il y a d'autres manifestations, plus rares encore, comme le syndrome cérébelleux, l'atteinte des nerfs crâniens (névrite optique, atrophie optique .…”

Section: Manifestations Neuropsychiatriquesunclassified

Carence en vitamine B12 (1^repartie) : mise au point

Loup-Leuciuc

Loup

Lombardi

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 12 mai 2011, accepté le 24 juin 2011) Mots clés : vitamine B12 / métabolisme / carence / manifestationsRésumé -Classiquement, la carence en vitamine B12 s'accompagne d'une anémie mégaloblastique, de manifestations neuropsychiatriques et d'une glossite de Hunter. En réalité, les manifestations sont protéiformes et chacune d'elles peut rester longtemps isolée. Les manifestations stomatologiques, souvent discrètes, peuvent précéder de plusieurs années les autres manifestations. Elles constituent parfois un signe d'appel pour le dépistage précoce de cette carence. Depuis une bonne dizaine d'années, la conception de la physiopathologie de la carence en vitamine B12 a beaucoup évolué : on a identifié le syndrome de non-dissociation de la vitamine B12 des protéines porteuses qui constitue maintenant la principale cause de carence en vitamine B12 et il a été démontré qu'on peut effectuer un traitement de la carence per os. Key words: vitamin B12 / metabolism / deficiency / manifestationsAbstract -Vitamin B12 deficency. Part 1: update and littérature review. Vitamin B12 deficiency is classically accompanied by a megaloblastic anemia, neuropsychiatric disorders and an Hunter glossitis. Clinical manifestations are indeed polymorphic and each may remain the only one for a long period of time. Stomatological manifestations, often mild, may precede the others of many years. They sometimes are the first sign to early diagnose this deficiency. Since the last ten years, the physiopathology of vitamin B12 deficiency has considerably changed. In fact, nowadays, the main cause is the syndrome of food cobalamin malabsorption. It has also been demonstrated that the deficiency may now treated by an oral cobalamin therapy.La vitamine B12 est une vitamine hydrosoluble qui a une structure chimique proche de celle de l'hème avec un atome central constitué par du cobalt, d'où le nom de cobalamine (Fig. 1).Elle existe sous plusieurs formes regroupées dans la famille des cobalamines : cyanocobalamine, hydroxocobalamine, mé-thylcobalamine et adénosylcobalamine. La cyanocobalamine et l'hydroxocobalamine sont les seules formes stables. On peut considérer que les recherches sur la vitamine B12 ont commencé au XIX e siècle avec la description d'une anémie mortelle, l'anémie pernicieuse, par Thomas Addison et Michael Anton Biermer. Vers 1920, George Whipple, George Minot et William Murphy, tous les trois Prix Nobel de médecine en 1934, ont démontré que des extraits de foie sous forme de compléments alimentaires étaient susceptibles de corriger certaines anémies. On en a conclu que les extraits de foie contenaient le facteur extrinsèque, en réalité de la vitamine

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Carence en vitamine B12, ataxie cérébelleuse et troubles cognitifs

Cited by 7 publications

References 9 publications

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Clinical Reasoning: An Unusual Case of Acute Psychosis and Tetraparesis in a Young Zambian Man

Carence en vitamine B12 (1^repartie) : mise au point

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Carence en vitamine B12, ataxie cérébelleuse et troubles cognitifs

Cited by 7 publications

References 9 publications

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report

Clinical Reasoning: An Unusual Case of Acute Psychosis and Tetraparesis in a Young Zambian Man

Carence en vitamine B12 (1repartie) : mise au point

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Carence en vitamine B12 (1^repartie) : mise au point