Cardiovascular support during neonatal intensive care

Brunton, Andrew; Turner, Mark A.; Paize, Fauzia

doi:10.1016/j.paed.2015.02.004

Cited by 2 publications

(1 citation statement)

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“…It has strong α-mimetic and β1mimetic effects, and lower β2 effects. At lower doses increased contractility and heart rate are observed, at higher doses net effects are increased vascular resistance and blood pressure [75]. Vasoconstriction may also increase afterload resulting in increased myocardial work load.…”

Section: Norepinephrinementioning

confidence: 99%

Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data

Ergenekon

Rojas-Anaya

Bravo

et al. 2018

CPD

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Background: Circulatory failure in preterm and term newborn infants is commonly treated with inotropes or vasoactive medications. In this structured literature review the available data on pharmacodynamic effects of the inotropes adrenaline, dobutamine, dopamine, levosimendan, milrinone, noradrenaline, and the vasoactive drugs vasopressin and hydrocortisone are presented. Methods: Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria which were human clinical trials published after 2000.Results: Out of 101 identified eligible studies only 22 studies met the criteria for evidence based practice guidelines level I to IV. The most prevalent pharmacodynamic effects were increase in blood pressure and/or heart rate, which were also the most frequently studied circulatory parameters. Conclusion: This review demonstrates the need for further systematic studies on all reviewed drugs with incorporation of novel noninvasive biomarkers in this vulnerable patient group, for more timely and appropriate treatment for clinical efficacy.

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Section: Norepinephrinementioning

confidence: 99%