Cardiovascular Risks of Nonsteroidal Antiinflammatory Drugs in Patients After Hospitalization for Serious Coronary Heart Disease

Abstract

Background-The cardiovascular safety of individual nonsteroidal antiinflammatory drugs (NSAIDs) is highly controversial, particularly in persons with serious coronary heart disease. Methods and Results-We conducted a multisite retrospective cohort study of commonly used individual NSAIDs in Tennessee Medicaid, Saskatchewan Health, and United Kingdom General Practice Research databases. The cohort included 48 566 patients recently hospitalized for myocardial infarction, revascularization, or unstable angina pectoris with more than 111 000 person-years of follow-up. Naproxen users had the lowest adjusted rates of serious coronary heart disease (myocardial infarction, coronary heart disease death) and serious cardiovascular disease (myocardial infarction, stroke)/death from any cause, with respective incidence rate ratios (relative to NSAID nonusers) of 0.

Treatment of Elderly Patients With Dorsopathy

“…В особенности про-блема осложнений лекарственной терапии значима для пожилых пациентов, страдающих целым рядом соматиче-ских заболеваний, вынужденных одновременно прини-мать значительное количество лекарственных препара-тов. Наиболее частыми являются осложнения со стороны желудочно-кишечного тракта (язва желудка, 12-перстной кишки), печени, почек, сердечно-сосудистой системы (ате-ротромбоз, повышение артериального давления) [6,7]. В связи с достаточно высоким риском развития осложне-ний проблема безопасности терапии является не менее значимой, чем эффективное и своевременное купирова-ние болевого синдрома.…”

Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives

“…[1][2][3] Although non steroidal antiinflammatory drugs possess great safety over steroidal drugs, they still have some side effects as development of peptic and duodenal ulcers, kidney and liver malfunctions. [4][5][6] The rise of selective cyclooxygenase-2 (COX-2) inhibitors reduced the risk of some of these side effects.…”

Acute Pain Management in the Emergency Department: Emphasis on NSAIDs

“…For example, rofecoxib has been taken off the market due to CV safety concerns [105]. Both longterm [102,103] and short-term [106,107] use of NSAIDs have been associated with CV risk. While more pronounced with selective COX-2 inhibitors, some non selective NSAIDS have also been linked with cardiac risk [108,109].…”