Cardiovascular Risk in Patients with Nonfunctional Adrenal Incidentaloma: Myth or Reality?

Erbil, Yeşim; Özbey, Neşe; Barbaros, Umut; Ünalp, Haluk Recai; Salmaslıoğlu, Artür; Özarmağan, Selçuk

doi:10.1007/s00268-009-0178-0

Cited by 32 publications

(15 citation statements)

References 21 publications

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“…In a previous report, even patients with nonfunctioning AIs (defined as cortisol level <1.8 mg/dL after LDDST) also had less FMD compared with age-matched, sex-matched, BMI-matched subjects and cardiometabolic controls. 19 A very recent study by Debono and colleagues 20 also confirmed this association. In a retrospective study of 206 patients, all with adrenal adenomas, patients were categorized as having cortisol concentrations greater than 1.8 mg/dL after 1-mg LDDST or having cortisol concentrations less than 1.8 mg/dL after 1-mg LDDST.…”

Section: Cardiovascular Diseasesupporting

confidence: 57%

Adrenal Mild Hypercortisolism

Goddard¹,

Ravikumar²,

Levine³

2015

Endocrinology and Metabolism Clinics of North America

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Section: Cardiovascular Diseasesupporting

confidence: 57%

Adrenal Mild Hypercortisolism

Goddard¹,

Ravikumar²,

Levine³

2015

Endocrinology and Metabolism Clinics of North America

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“…In 2009, Erbil et al [9] compared a group of patients with confirmed non-functioning adenomas against age and body-mass index matched controls. They reported decreased flow mediated dilatation, along with an increased prevalence of the metabolic syndrome, in the adenoma group.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of adrenal incidentaloma in routine clinical practice

et al. 2011

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The prevalence of adrenal incidentaloma (AI) on computed tomography (CT) in the general population has been reported to be as high as 4.2%. However, many of the previous studies in this field utilised a prospective approach with analysis of CT scans performed by one or more radiologists with a specialist interest in adrenal tumours and a specific focus on identifying the presence of an adrenal mass. A typical radiology department, with a focus on the patient's presenting complaint as opposed to the adrenal gland, may not be expected to diagnose as many adrenal incidentalomas as would be identified in a dedicated research protocol. We hypothesised that the number of AI reported in routine clinical practice is significantly lower than the published figures would suggest. We retrospectively reviewed the reports of all CT thorax and abdomen scans performed in our hospital over a 2 year period. 3,099 patients underwent imaging, with 3,705 scans performed. The median age was 63 years (range 18-98). Thirty-seven true AI were diagnosed during the time period studied. Twenty-two were diagnosed by CT abdomen (22/2,227) and 12 by CT thorax (12/1,478), a prevalence of 0.98 and 0.81% with CT abdomen and thorax, respectively, for AI in routine clinical practice.

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“…However, long-term data on the natural evolution and potential changes in size and pattern of secretion of these tumours is still scarce. Increasing evidence suggests that even the apparently non-functioning adrenal adenomas may be associated with higher prevalence of hypertension and a variety of metabolic abnormalities such as obesity, diabetes mellitus type 2, impairments of glucose metabolism and dyslipidaemia compared to the general population [11][12][13][14][15][16][17][18][19]. These derangements are usually explained by subtle autonomous hormonal secretion, mostly of cortisol, that is insufficient to cause the typical clinical manifestations of overt Cushing's syndrome.…”

Section: Introductionmentioning

confidence: 99%