Adrenal Mild Hypercortisolism

Aestivationmotifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect

“…We conclude that chronic water loss across a defective skin or kidney barrier not only triggers compensatory circulatory aestivation motifs that will ultimately increase blood pressure, but in parallel causes exploitation of the energy and nitrogen reservoirs in skeletal muscle. Given the fact that even mild underlying glucocorticoid‐driven catabolic states represent a major risk factor for adverse cardiovascular outcome and are strong predictors of increased mortality independent of their underlying cause, 44 we speculate that parallel catabolism might be an underestimated cause of adverse health events in patients and in experimental animals with arterial hypertension.…”

The association between adrenal adenoma size, autonomous cortisol secretion and metabolic derangements

“…The association between mild cortisol hypersecretion and metabolic alterations has been widely explored 5,12,14,17,21,31–34 . While most existing data dichotomizes cortisol hypersecretion based on specific cutoff values, 1,2,8,9,34–36 we recently showed that cortisol autonomy is a continuous linear risk factor for metabolic derangements and that this association intensifies as more MS criteria are present 7 …”

Cardiovascular events in patients with mild autonomous cortisol secretion: analysis with artificial neural networks

“…The condition of mild autonomous cortisol secretion (ACS) is characterized by an increased cortisol secretion in the absence of the classical signs of overt cortisol excess (1,2), and it is found in up to 20% of patients bearing an incidentally discovered adrenal mass (adrenal incidentaloma, AI) (3,4). In adults, mild ACS has a 0.2-2.0% prevalence and it seems to be associated with an increased risk of fragility fractures, dyslipidemia (DL), type 2 diabetes (T2DM), hypertension (AH), cardiovascular events (CVE) and mortality (5,6,7,8,9,10,11).…”