Cardiovascular Risk Factors and Distributions of the Ankle-Brachial Index among Type 2 Diabetes Mellitus Patients

Doza, Badaruddoza; Kaur, Manpreet; Chopra, Sonia; Kapoor, Rohit

doi:10.1155/2012/485812

Cited by 13 publications

(17 citation statements)

References 16 publications

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“…It was verified that the prevalence of high ABI in the overweight participants was higher than those with normal body weight, which suggested that overweight contributed to the development of high ABI. Our findings are largely consistent with prior studies 7, 8, 17. Adragao et al showed that BMI was not significantly different between patients with normal and high ABI.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, the present study showed that the values of BMI increased in the high ABI group. This result was similar to some studies 7, 8. Recently, obesity was considered as a state of chronic inflammation 24.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, the participants with hypertension were also identified to have significantly higher prevalence of high ABI than those without hypertension. This result was similar to some studies which suggested that participants with high ABI had higher level of blood pressure than those with normal ABI 7, 8, 17. However, the study showed that the prevalence of high ABI was not significantly different between participants with and without hyperglycemia, and was not significantly different between participants with and without dyslipidemia.…”

Section: Discussionsupporting

confidence: 90%

“…In the study of Lee et al, a significantly positive correlation was found between coronary artery calcification and MetS, but the participants with CRF were not excluded 16. Moreover, many studies found that the metabolic risk factors might have independent correlation with high ABI 7, 8. The present study was the first one to confirm that, among the participants without CRF, those with MetS had significant higher prevalence of high ABI than the participants without MetS.…”

Section: Discussionsupporting

confidence: 52%

“…But the associated factors of high ABI are still under debate. A recent study showed that age, body mass index (BMI) and blood pressures were significantly associated with ABI value in both sexes among people with type 2 diabetes mellitus (DM) in north India 7. Another study indicated that, in Chinese population, those with high ABI had significant higher BMI and blood pressure 8.…”

Section: Introductionmentioning

confidence: 99%

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Inflammation and Oxidative Stress are Associated with the Prevalence of High Aankle-brachial Index in Metabolic Syndrome Patients without Chronic Renal Failure

Zhang¹,

Chen²,

Zhang³

et al. 2013

Int. J. Med. Sci.

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Aims: High ankle-brachial index (ABI) is marker of increased cardiovascular morbidity and mortality, while the relationship and mechanism between high ABI and metabolic syndrome (MetS) are unclear. The objectives of this study were to determine the relationship and possible mechanism of MetS with high ABI.Methods: 341 participants without CRF were recruited. Among these participants, 58 participants (ABI ≥ 1.3) were include in high ABI group and the other 283 participants (0.9 < ABI < 1.3) were include in normal ABI group. Furthermore, these 341 participants were also divided into MetS group (n = 54) and non-MetS group (n = 287). All participants received examinations including body mass index (BMI), ABI and related biochemical parameters.Results: Compared with non-MetS group, the prevalence of high ABI was higher in MetS group (27.8% vs. 15%, p < 0.05). Participants with 3-4 metabolic risk factors had higher prevalence of high ABI than those with 0-1 metabolic risk factors (27.8% vs. 12.7%, p < 0.05). The prevalence of high ABI in overweight participants was higher than those with normal body weight. And the participants with hypertension also had higher prevalence of high ABI than normotensive participants. BMI, high-sensitivity C-reactive protein (hsCRP) and superoxide dismutase (SOD) were all higher in high ABI group than normal ABI group (p < 0.05).Conclusions: More metabolic risk factors have increased the risk of high ABI. Inflammation and oxidative stress are associated with prevalence of high ABI in metabolic syndrome patients without chronic renal failure.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inflammation and Oxidative Stress are Associated with the Prevalence of High Aankle-brachial Index in Metabolic Syndrome Patients without Chronic Renal Failure

Zhang¹,

Chen²,

Zhang³

et al. 2013

Int. J. Med. Sci.

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Association of body mass index and left ventricular mass index with abnormally low and high ankle-brachial indices in chronic kidney disease

et al. 2015

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Obesity, left ventricular hypertrophy (LVH) and peripheral artery disease are frequently noted in patients with chronic kidney disease (CKD), thereby suggesting a close and causal relationship among them. This study was designed to assess whether the combination of an increased body mass index (BMI) and left ventricular mass index (LVMI) are independently associated with abnormally low and high ABI in patients with CKD stages 3-5. A total of 566 patients were included in the study and were classified into four groups according to sex-specific median BMIs and LVMIs. The ABI was measured using an ABI-form device. Abnormally low and high ABI was defined as ABI <0.9 or ⩾1.3 in either leg. The combination of high BMI and LVMI (vs. the combination of low BMI and LVMI) was significantly associated with abnormally low and high ABI in an unadjusted model (odds ratio (OR), 2.107; P=0.015) and in a multivariable model after adjustment for demographic, clinical and biochemical characteristics and medications (OR, 4.219; P=0.008). In addition, the interaction between BMI and LVMI in abnormally low and high ABI was statistically significant in the unadjusted (OR, 1.002; P=0.001) and multivariate models (OR, 1.004; P=0.003). Our findings show that the combination of high BMI and LVMI was associated with abnormally low and high ABI in patients with CKD stages 3-5. Patients with high BMI and LVMI might be at a high risk of abnormally low and high ABI.

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A Cross-sectional Study of the Relationship Between Habitual Tea Consumption and Arterial Stiffness

Lin

Qiu²,

Wang

et al. 2015

Journal of the American College of Nutrition

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Cardiovascular Risk Factors and Distributions of the Ankle-Brachial Index among Type 2 Diabetes Mellitus Patients

Cited by 13 publications

References 16 publications

Inflammation and Oxidative Stress are Associated with the Prevalence of High Aankle-brachial Index in Metabolic Syndrome Patients without Chronic Renal Failure

Inflammation and Oxidative Stress are Associated with the Prevalence of High Aankle-brachial Index in Metabolic Syndrome Patients without Chronic Renal Failure

Association of body mass index and left ventricular mass index with abnormally low and high ankle-brachial indices in chronic kidney disease

A Cross-sectional Study of the Relationship Between Habitual Tea Consumption and Arterial Stiffness

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