Association of body mass index and left ventricular mass index with abnormally low and high ankle-brachial indices in chronic kidney disease

Chen, Szu-Chia; Lee, Wen-Hsien; Hsu, Po-Chao; Huang, Jiun-Chi; Lee, Chee-Siong; Lin, Tsung-Hsien; Voon, Wen‐Chol; Lai, Wen‐Ter; Sheu, Sheng‐Hsiung; Su, Ho‐Ming

doi:10.1038/hr.2015.128

Cited by 6 publications

(5 citation statements)

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“…In addition, many factors including pressure overload, renal anemia, malnutrition, and inflammatory status have been reported to be both main causes of the development of LVH and also for atherosclerosis in patients undergoing HD2324. Furthermore, previous studies have demonstrated significantly lower ABI values in patients with LVH than in those without LVH, and that ABI was independently and inversely associated with left ventricular mass index2526. These results suggest that a low ABI may be related to LVH.…”

Section: Discussionmentioning

confidence: 77%

Association of Ankle-Brachial Index and Aortic Arch Calcification with Overall and Cardiovascular Mortality in Hemodialysis

Chen

Lee

Huang

et al. 2016

Sci Rep

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Peripheral artery occlusive disease and vascular calcification are highly prevalent in hemodialysis (HD) patients, however the association of the combination of ankle-brachial index (ABI) and aortic arch calcification (AoAC) with clinical outcomes in patients undergoing HD is unknown. In this study, we investigated whether the combination of ABI and AoAC is independently associated with overall and cardiovascular mortality in HD patients. The median follow-up period was 5.7 years. Calcification of the aortic arch was assessed by chest X-ray. Forty-seven patients died including 24 due to cardiovascular causes during the follow-up period. The study patients were stratified into four groups according to an ABI < 0.95 or ≥0.95 and an AoAC score of >4 or ≤4 according to receiver operating characteristic curve. Those with an ABI < 0.95 and AoAC > 4 (vs. ABI ≥ 0.95 and AoAC score ≤ 4) were associated with overall (hazard ratio [HR], 4.913; 95% confidence interval [CI], 1.932 to 12.497; p = 0.001) and cardiovascular (HR, 3.531; 95% CI, 1.070 to 11.652; p = 0.038) mortality in multivariable analysis. The combination of a low ABI and increased AoAC was associated with increased overall and cardiovascular mortality in patients undergoing HD.

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Section: Discussionmentioning

confidence: 77%

Association of Ankle-Brachial Index and Aortic Arch Calcification with Overall and Cardiovascular Mortality in Hemodialysis

Chen

Lee

Huang

et al. 2016

Sci Rep

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“…This result has been confirmed in several subsequent studies 12 . In addition, abnormally low ABI is independently associated with increased LVM in people with hypertension or chronic kidney disease 13,14 . Recently, Hidekazu and co‐workers found that a high ABI in the normal range was significantly associated with ECG‐determined LVH in a cross‐sectional study of Japanese community populations 15 .…”

Section: Introductionmentioning

confidence: 63%

“… 12 In addition, abnormally low ABI is independently associated with increased LVM in people with hypertension or chronic kidney disease. 13 , 14 Recently, Hidekazu and co‐workers found that a high ABI in the normal range was significantly associated with ECG‐determined LVH in a cross‐sectional study of Japanese community populations. 15 However, the relationship between high ABI within the normal range and LVH in patients with hypertension is still unknown.…”

Section: Introductionmentioning

confidence: 99%

The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese

Sun

Wang

et al. 2021

J of Clinical Hypertension

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Left ventricular hypertrophy (LVH) is the most common target organs damage in the hypertension patients. Abnormal low (≤0.9) or high (≥1.40) ankle brachial index (ABI) are associated with an increased risk of cardiovascular events. However, the relationships between a high ABI in the normal range (0.9–1.4) and LVH in Han Chinese hypertension are not entirely elucidated. This study included 3953 hypertension patients aged 40–75 years among Han Chinese. Hypertension was defined as systolic blood pressure≥140 mm Hg, diastolic blood pressure≥90 mm Hg, or history of antihypertensive drug use. Left ventricular mass (LVM) was measured by transthoracic echocardiography. LVH was diagnosed by using the criteria of LVM ≥49.2 g/m2.7 for men and 46.7 g/m2.7 for women. Our study suggested that the ABI was higher in patients with LVH than in those without (1.13±0.11, 1.11±0.11, p < 0.001). The prevalence of LVH in patients with the lowest (0.9 < ABI≤1.03), second (1.04≤ABI≤1.11), the third (1.12≤ABI≤1.20), and the highest quartile (1.21≤ABI < 1.40) of ABI was 37.2%, 38.2%, 45.5%, 45.7%, respectively. Logistic regression analysis suggested that the highest and third quartile of ABI were significantly associated with increased LVH risk (multivariate‐adjusted OR of highest group:1.83; third group:1.61). The association of ABI at second quartile with LVH was nonsignificant. Similar results were observed in less than 60 years and without coronary heart disease or diabetes group. Our observations in Chinese patients with hypertension indicated high ABI may be an important risk factor for LVH in hypertension patients among Han Chinese, even in the normal range.

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“…PAD was also independently associated with LVMI by a multivariable analysis. It has been shown that, among patients with CKD, those with higher BMI and LVMI tend to have an abnormal ABI [ 26 ]. It has also been suggested that adding ABI to the Framingham risk score may provide a more accurate assessment of all-cause mortality, including cardiovascular death [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Association Between the Presence of Coronary Artery Disease or Peripheral Artery Disease and Left Ventricular Mass in Patients Who Have Undergone Coronary Computed Tomography Angiography

Tachibana,

Shiga,

Hirata

et al. 2023

Cardiol Res

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Background Left ventricular mass (LVM) is a critical marker of future cardiovascular risk. We determined the association between LVM measured by coronary computed tomography angiography (CCTA) and the presence of coronary artery disease (CAD) or peripheral artery disease (PAD) in patients who had undergone CCTA for screening of CAD. Methods We enrolled 1,307 consecutive patients (66 ± 12 years old, 49% males) who underwent CCTA for screening of CAD at the Fukuoka University Hospital (FU-CCTA registry), and either were clinically suspected of having CAD or had at least one cardiovascular risk factor. Patients with coronary stenosis of ≥ 50% by CCTA were diagnosed as CAD. Patients with an ankle brachial pressure index < 0.9 or who had already been diagnosed with PAD were considered to have PAD. Left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV) were measured. The patients were divided into CAD (-) and CAD (+) or PAD (-) and PAD (+) groups. Results The prevalences of CAD and PAD in all patients were 50% and 4.8%, respectively. Age, %males, %hypertension (HTN), %dyslipidemia (DL), %diabetes mellitus (DM), %smoking and %chronic kidney disease in the CAD (+) group were significantly higher than those in the CAD (-) group. Age, %males, %HTN, %DM and %smoking in the PAD (+) group were significantly higher than those in the PAD (-) group. CAD was independently associated with LVMI (odds ratio (OR): 1.01, 95% confidence interval (CI): 1.01 - 1.02, P < 0.01) in addition to age, male, HTN, DL, DM, and smoking. PAD was also independently associated with LVMI (OR: 1.01, 95% CI: 1.0 - 1.02, P = 0.018) in addition to age, DM, and smoking. Conclusions LVMI determined by CCTA may be useful for predicting atherosclerotic cardiovascular diseases including both CAD and PAD, although there were considerable differences between %CAD and %PAD in all patients.

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Association of body mass index and left ventricular mass index with abnormally low and high ankle-brachial indices in chronic kidney disease

Cited by 6 publications

References 50 publications

Association of Ankle-Brachial Index and Aortic Arch Calcification with Overall and Cardiovascular Mortality in Hemodialysis

Association of Ankle-Brachial Index and Aortic Arch Calcification with Overall and Cardiovascular Mortality in Hemodialysis

The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese

Association Between the Presence of Coronary Artery Disease or Peripheral Artery Disease and Left Ventricular Mass in Patients Who Have Undergone Coronary Computed Tomography Angiography

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