Cardiovascular receptor binding affinity of aqueous extracts from<i>Allium</i>species

Nencini, Cristina; Franchi, Gian Gabriele; Micheli, Lucia

doi:10.3109/09637481003591608

Cited by 8 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study confirms the results obtained in previous researches [19,21,22]; in fact, these studies yet showed that the wild-type species of Allium, and in particular leaves and flowers, are more active and efficient in respect to garlic bulbs.…”

Section: Resultssupporting

confidence: 95%

“…These results suggest further researches on spontaneous Allium species, in the past used as food or vegetables [20] and actually not much investigated. In effect these spontaneous Allium species resulted more active than A. sativum also in two successive studies by Nencini et al [21,22]. In the present study, we investigated the in vitro antioxidant activity of aged (up to 20 months) 15% hydroethanolic extracts of bulbs, leaves, flowers, bulblets and flower bulblets (these latter obviously only when present) of three Allium spontaneous species, previously studied on fresh material [19]: Allium neapolitanum Cyr., Allium roseum L., Allium subhirsutum L., and the in vitro antioxidant activity of aged 15% hydroethanolic extracts of bulbs and leaves of garlic (Allium sativum L.).…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

In vitro Antioxidant Activity of Aged Extracts of some Italian Allium Species

Nencini

Menchiari

Franchi

et al. 2011

Plant Foods Hum Nutr

Self Cite

106

View full text Add to dashboard Cite

Antioxidant activity of fresh Allium sativum L. (garlic) is well known and is mainly due to unstable and irritating organosulphur compounds. Fresh garlic extracted over a prolonged period (up to 20 months) produces odourless aged garlic extract (AGE) containing stable and water soluble organosulphur compounds that prevent oxidative damage by scavenging free radicals. The aim of this study was to investigate the in vitro antioxidant activity of aged (up to 20 months) 15% hydroethanolic extracts of different parts (bulbs, bulblets, flower bulblets, flowers, and leaves) of three Allium spontaneous species which are endemic for Italian flora: Allium neapolitanum Cyr., Allium subhirsutum L., Allium roseum L. and to compare it with the in vitro antioxidant activity of aged 15% hydroethanolic extracts of bulbs and leaves of garlic. The antioxidant potential of aged extracts of all species has been evaluated using two different spectrophotometric assays: 2,2-diphenylpicrylhydrazyl (DPPH) test and the ferric reducing/antioxidant power (FRAP) assay. Furthermore the polyphenol content was determined. The aged extracts obtained from the leaves showed the best antioxidant activity, followed by flowers and then by bulbs in both used tests, while flower bulblets and bulblets exhibited lower results or no activity. The polyphenol content was generally directly correlated with antioxidant/antiradical activity. This study confirms the data obtained in previous researches, the wild-type species of Allium and in particular organs other than bulbs are more active and efficacious than garlic bulb. Surely leaves of these Allium spp. deserve special attention.

show abstract

Section: Resultssupporting

confidence: 95%

Section: Introductionmentioning

confidence: 87%

In vitro Antioxidant Activity of Aged Extracts of some Italian Allium Species

Nencini

Menchiari

Franchi

et al. 2011

Plant Foods Hum Nutr

Self Cite

106

View full text Add to dashboard Cite

show abstract

“…Nencini et al . [29] reported that A. sativum L. did not show high affinity for α 1 and α 2 receptors and showed a partial affinity for β 1 receptors, whereas wild-type Allium species presented a greater affinity for these receptors, in particular for β 2 receptors ( Allium neapolitanum and Allium subhirsutum species).…”

Section: Discussionmentioning

confidence: 99%

The relaxant effect induced by Allium sativum L. bulb aqueous extract on rat isolated trachea

Fehri¹,

Ahmed

Aiache

2011

Phcog Mag

View full text Add to dashboard Cite

Background:Garlic plays an important role in complementary and alternative medicine. Most people believe in and use herbal products even when they have not been as thoroughly researched as garlic. Garlic is also known for its beneficial effects on the cardiovascular system.Materials and Methods:The relaxant effect of Allium sativum L. bulb aqueous extract (ASBAE) containing 0.06%-0.10% of allicin was studied on isolated smooth muscle of trachea of rats precontracted using acetylcholine (10−5 M).Results:It was found that ASBAE induced a dose-dependent relaxation with recorded EC 50 values of 71.87 ± 5.90 µg/mL (n = 7). Pretreatments with mepyramine (10−7 M), methysergide (10−7 M), caffeine (10−6 M), theophylline (10−6 M), nifedipine (10−6 M), and dipyridamole (10−6 M) did not alter ASBAE concentration-response curves. In turn, concentration-response curves to ASBAE were significantly shifted toward right in the presence of aspirin (3.10−3 M), indomethacin (10−6 M), prazosin (10−6 M), and propranolol (10−7 M).Conclusion:It is suggested that the recorded relaxation results are due to the release of prostaglandins E 1 and E 2 consecutively to α- and β-adrenoreceptor stimulation.

show abstract

“…Known as garlic, it belongs to family Amaryllidaceae. It is known for its cardioprotective properties for milleniums (Fehri et al, 2011;Nencini et al, 2010;Ried et al, 2010) including vasorelaxant, antithrombotic and antiatherosclerotic by inhibiting platelet aggregation and plaque progression and by lowering cholestrol level in arterial cells (Koscielny et al, 1999;Orekhov et al, 1997). Seven dipeptides are found in allium extracts which are angiotensin converting enzyme (ACE)-inhibitors thus making it effective antihypertensive agent (Suetsuna et al, 1998).…”

Section: Allium Sativummentioning

confidence: 99%

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

Altaf¹

2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Herbal medicines are being centrally focused since ages for the screening of newer and better treatment of health problems especially cardiac diseases. In the current manuscript, we have reviewed a number of important constituents of different herbs and plants, which belong to a wide range of families that affect the cardiovascular system by acting through one mechanism or the other as Rauwolfia serpentine, Nigella sativa, Curcuma longa and Allium sativum. However, there is an evidence for a considerable number of plants such as Phaleria macrocarpa, Inula racemosa, Panax notoginseng etc., that contain constituents affecting the cardiovascular system and can be beneficial for cardiac problems, but still need further investigation and pharmacological evaluation.

show abstract

Cardiovascular receptor binding affinity of aqueous extracts fromAlliumspecies

Abstract: The known antihypertensive activity of Allium sativum cannot be correlated with binding to receptors involved in blood pressure regulation. However, aqueous extracts of the wild-type species of Allium show much higher affinities, warranting further explorations.

Cited by 8 publications

References 20 publications

In vitro Antioxidant Activity of Aged Extracts of some Italian Allium Species

In vitro Antioxidant Activity of Aged Extracts of some Italian Allium Species

The relaxant effect induced by Allium sativum L. bulb aqueous extract on rat isolated trachea

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

Contact Info

Product

Resources

About