Cardiovascular protective properties of oxytocin against COVID-19

Wang, Stephani C.; Wang, Yufeng

doi:10.1016/j.lfs.2021.119130

Cited by 22 publications

(19 citation statements)

References 168 publications

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“…It reveals that abnormally increased hypothalamic OT secretion is a key for CDassociated maternal depression, release of inflammatory cytokines and decrease in lymphocytes. Many of the present findings remain to be further verified in a more specific condition, which is important not only for treatment of abnormal maternal behaviors but also for a variety of diseases with immune disorders like COVID-19 (S. C. Wang and Wang, 2021).…”

Section: Discussionmentioning

confidence: 83%

Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery

Jia

Hou

et al. 2021

ASN Neuro

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Oxytocin (OT), a neuropeptide produced in the supraoptic (SON) and paraventricular (PVN) nuclei, is not only essential for lactation and maternal behavior but also for normal immunological activity. However, mechanisms underlying OT regulation of maternal behavior and its association with immunity around parturition, particularly under mental and physical stress, remain unclear. Here, we observed effects of OT on maternal behavior in association with immunological activity in rats after cesarean delivery (CD), a model of reproductive stress. CD significantly reduced maternal interests to the pups throughout postpartum day 1-8. On postpartum day 5, CD decreased plasma OT levels and thymic index but increased vasopressin, interleukin (IL)-1β, IL-6 and IL-10 levels. CD had no significant effect on plasma adrenocorticotropic hormone and corticosterone levels. In the hypothalamus, CD decreased corticotropin-releasing hormone contents in the PVN but increased OT contents in the PVN and SON and OT release from hypothalamic implants. CD also increased c-Fos expression, particularly in the cytoplasm of OT neurons. Lastly, CD depolarized resting membrane potential and increased spike width while increasing the variability of the firing rate of OT neurons in brain slices. Thus, CD can increase hypothalamic OT contents and release but reduce pituitary release of OT into the blood, which is associated with depressive-like maternal behavior, increased inflammatory cytokine release and decreased relative weight of the thymus.

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Section: Discussionmentioning

confidence: 83%

Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery

Jia

Hou

et al. 2021

ASN Neuro

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“…In addition to the young age of our adults’ cohort, another hypothesis explaining the absence of severe COVID-19 in adults with PWS could be the beneficial role of oxytocin (OXT). Indeed, OXT, a neuropeptide produced in the hypothalamic paraventricular nucleus and supraoptic nucleus, is an immune-regulating neuropeptide, which has recently emerged as a candidate for treatment and prevention of COVID-19 [ 17 – 19 ]. OXT seems to carry special functions in immunologic defense: it suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes negative effects of angiotensin II and other key pathological events of COVID-19 [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, OXT, a neuropeptide produced in the hypothalamic paraventricular nucleus and supraoptic nucleus, is an immune-regulating neuropeptide, which has recently emerged as a candidate for treatment and prevention of COVID-19 [ 17 – 19 ]. OXT seems to carry special functions in immunologic defense: it suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes negative effects of angiotensin II and other key pathological events of COVID-19 [ 19 ]. Through these mechanisms, OXT can block viral invasion, suppress cytokine storm, reverse lymphocytopenia, and prevent progression to severe COVID-19 [ 17 – 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…OXT seems to carry special functions in immunologic defense: it suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes negative effects of angiotensin II and other key pathological events of COVID-19 [ 19 ]. Through these mechanisms, OXT can block viral invasion, suppress cytokine storm, reverse lymphocytopenia, and prevent progression to severe COVID-19 [ 17 – 19 ]. OXT system is impaired in most patients with PWS [ 2 ] and the high plasmatic levels of OXT (possibly due to overcompensation of a brain deficit) in patients with PWS could play a protective role against COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients

Coupaye

Laurier

Benvegnu

et al. 2021

Orphanet J Rare Dis

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Background Patients with Prader-Willi syndrome (PWS) often have comorbidities, especially obesity, that may constitute a risk factor for severe forms of COVID-19. We aimed to assess prevalence and medical course of SARS-CoV-2 infection in children and adults with PWS. From November 2020 to January 2021, we performed a detailed medical survey on 342 adults and 305 children with PWS followed in the French reference center. Results We obtained responses from 288 adults (84%) and 239 children (78%). From March 2020 to January 2021, 38 adults (13.2%) and 13 children (5.4%) with PWS had SARS-CoV-2 infection. Mean age of adults was 34.1 ± 11.9 years and mean body mass index was 40.6 ± 12.7 kg/m2; 82% had obesity and 37% had diabetes. Only 3 children (23%) had obesity and none had diabetes. Similar to the general population, the most frequent symptoms of COVID-19 were asthenia, fever, cough, headache and shortness of breath. All patients had a favorable outcome. Conclusion PWS itself is not a risk factor for severe COVID-19 in children and adults. On the contrary, evolution of SARS-CoV-2 infection in adults with PWS seems more favorable than expected, given their comorbidities.

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“…Not surprisingly, oxytocin has already been proposed as a treatment for COVID-19 due to numerous anti-inflammatory properties [ 16 ], antioxidant properties [ 20 ], anti-diabetic properties [ 21 , 22 ], cardioprotective properties [ 23 ], and even possible direct antiviral properties [ 24 ]. It is safe and easily administered intranasally [ 25 ].…”

mentioning

confidence: 99%

TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?

Diep

2022

Int Arch Allergy Immunol

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Cardiovascular protective properties of oxytocin against COVID-19

Cited by 22 publications

References 168 publications

Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery

Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery

Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients

TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?

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