TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?

Diep, Phuoc-Tan

doi:10.1159/000521246

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, TRP ion channels have also been implicated in obesity and diabetes as well as certain types of cancer via inflammation [ 5 , 64 , 85 , 99 , 100 ]. Recent studies have highlighted the participation of TRP ion channels in the infection process of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), suggesting their potential as therapeutic targets for SARS-CoV-2 and COVID-19 (coronavirus disease 2019) [ 24 , 101 , 102 , 103 ]. Therefore, when targeting TRPs for intervention against inflammation in these diseases, it is crucial to consider the pro-inflammatory or anti-inflammatory functions exhibited by TRPs within immune cells and choose whether to activate or inhibit TRP ion channels accordingly to suppress inflammation flare-ups.…”

Section: Discussionmentioning

confidence: 99%

TRP Ion Channels in Immune Cells and Their Implications for Inflammation

Yan,

Gao,

et al. 2024

IJMS

View full text Add to dashboard Cite

The transient receptor potential (TRP) ion channels act as cellular sensors and mediate a plethora of physiological processes, including somatosensation, proliferation, apoptosis, and metabolism. Under specific conditions, certain TRP channels are involved in inflammation and immune responses. Thus, focusing on the role of TRPs in immune system cells may contribute to resolving inflammation. In this review, we discuss the distribution of five subfamilies of mammalian TRP ion channels in immune system cells and how these ion channels function in inflammatory mechanisms. This review provides an overview of the current understanding of TRP ion channels in mediating inflammation and may offer potential avenues for therapeutic intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

TRP Ion Channels in Immune Cells and Their Implications for Inflammation

Yan,

Gao,

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…The use of OT as adjuvant therapy for this disease has been proposed on the basis of its anti-inflammatory and immune-modulating properties [143][144][145][146]. However, to the best of my knowledge, endogenous OT levels in COVID-19 patients have not been assessed, most likely due to the highly invasive nature of obtaining samples of cerebrospinal fluid and controversial reports on the correlation of OT levels measured in plasma or saliva with those from cerebrospinal fluid [147,148].…”

Section: Smell Taste and Nociception Disturbances Related To Deficien...mentioning

confidence: 99%

COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Kujundžić

2022

IJMS

View full text Add to dashboard Cite

Immune response to SARS-CoV-2 and ensuing inflammation pose a huge challenge to the host’s nicotinamide adenine dinucleotide (NAD+) metabolism. Humans depend on vitamin B3 for biosynthesis of NAD+, indispensable for many metabolic and NAD+-consuming signaling reactions. The balance between its utilization and resynthesis is vitally important. Many extra-pulmonary symptoms of COVID-19 strikingly resemble those of pellagra, vitamin B3 deficiency (e.g., diarrhoea, dermatitis, oral cavity and tongue manifestations, loss of smell and taste, mental confusion). In most developed countries, pellagra is successfully eradicated by vitamin B3 fortification programs. Thus, conceivably, it has not been suspected as a cause of COVID-19 symptoms. Here, the deregulation of the NAD+ metabolism in response to the SARS-CoV-2 infection is reviewed, with special emphasis on the differences in the NAD+ biosynthetic pathway’s efficiency in conditions predisposing for the development of serious COVID-19. SARS-CoV-2 infection-induced NAD+ depletion and the elevated levels of its metabolites contribute to the development of a systemic disease. Acute liberation of nicotinamide (NAM) in antiviral NAD+-consuming reactions potentiates “NAM drain”, cooperatively mediated by nicotinamide N-methyltransferase and aldehyde oxidase. “NAM drain” compromises the NAD+ salvage pathway’s fail-safe function. The robustness of the host’s NAD+ salvage pathway, prior to the SARS-CoV-2 infection, is an important determinant of COVID-19 severity and persistence of certain symptoms upon resolution of infection.

show abstract

Assessment of the Impact of SARS-CoV-2 Infection on the Sexual Function of Women, Levels of Oxytocin and Prolactin: A Prospective Cohort Study

Żak,

Starek,

Korga-Plewko

et al. 2024

JCM

View full text Add to dashboard Cite

(1) Background: There is a lack of direct evidence on whether SARS-CoV-2 affects women’s sexual function through a biological-organic mechanism. Existing studies on the topic are few and have produced contradictory results. This study aims to explore the possible relationship between sex hormones and sexual function in patients who have been infected with SARS-CoV-2. Moreover, we aimed to determine whether these changes are related to the clinical course of COVID-19 and whether they are temporary or long-lasting. (2) Methods: A study was conducted on 104 women, including 64 women infected with COVID-19 and a control group of 40 healthy women, between January 2021 and August 2022. Blood samples were collected to measure prolactin and oxytocin levels, and a clinical assessment was performed 3 and 6 months later. Sexual function self-assessment was captured based on the FSFI scale. (3) Results: Our study found that patients with severe COVID-19 had better sexual satisfaction scores one month after recovery but no discernible difference after six months. High levels of serum prolactin were observed in patients with active COVID-19 but became similar to a control group after one month and remained stable over time. Higher prolactin levels were significantly associated with increased arousal and hydration. Individuals with severe COVID-19 had notably low levels of plasma oxytocin, but there was no correlation between oxytocin levels and sexual satisfaction. (4) Conclusions: The gynecologic symptoms, as well as disturbances in oxytocin and prolactin levels, might be observed in a short time after infection. However, SARS-CoV-2 infection has no lasting effect on sexual function, oxytocin, and prolactin levels among women.

show abstract

TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?

Cited by 3 publications

References 24 publications

TRP Ion Channels in Immune Cells and Their Implications for Inflammation

TRP Ion Channels in Immune Cells and Their Implications for Inflammation

COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Assessment of the Impact of SARS-CoV-2 Infection on the Sexual Function of Women, Levels of Oxytocin and Prolactin: A Prospective Cohort Study

Contact Info

Product

Resources

About