Cardiovascular manifestations of Takayasu arteritis and their relationship to the disease activity: Analysis of 204 Korean patients at a single center

Lee, Ga Yeon; Jang, Shin Yi; Ko, Sung Min; Kim, Eun Kyoung; Lee, Sung Ho; Han, Hyejin; Choi, Seung–Hyuk; Kim, Young‐Wook; Choe, Yeon Hyeon; Kim, Duk Kyung

doi:10.1016/j.ijcard.2011.01.094

Cited by 144 publications

(120 citation statements)

References 30 publications

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“…[54] Asymptomatic AR (mild to moderate) was found in 34% and hypertrophy of the left ventricle in 25%, while seven patients (17%) had a stroke or a transient ischemic attack. [55] Lee et al [56] reported that, among their 26 TA patients with a dilated ascending aorta, 18 patients (69.2%) had AR of more than a mild degree. [56] Aortic regurgitation is an important risk factor for mortality of TA patients.…”

Section: Discussionmentioning

confidence: 99%

“…[55] Lee et al [56] reported that, among their 26 TA patients with a dilated ascending aorta, 18 patients (69.2%) had AR of more than a mild degree. [56] Aortic regurgitation is an important risk factor for mortality of TA patients. [52] It also decreases survival in young patients of 10-29 years old, and it may reduce the five-year survival to 40%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Aortic regurgitation and aortic valve operation in Takayasu arteritis: A meta-analysis

Yuan¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada Takayasu arteriti olan hastaların majör bir komplikasyonu olabilen aort regürjitasyonunun klinik özellikleri ile beraber bu hastalarda gereken aort kapak ameliyatları tanımlandı.Ça lış ma pla nı: Bu meta-analiz; literatürden erişilen, Ocak 2001 ve Aralık 2016 tarihleri arasında yayınlanan ve 159 Takayasu arteriti hastasını içeren 41 ilgili yazıya dayandırıldı. On iki erkek ve 55 kadın hasta varken 92 hastanın cinsiyet bilgisi yoktu. Bul gu lar:Takayasu arteriti popülasyonunun aort regürjitasyonu hastası profili; kadın cinsiyetinin, tip 2a Takayasu arteritinin ve aort regürjitasyonunun şiddetli derecesinin hakim olduğunu gösterdi. Çoğu, en yaygını aort kapak replasmanı veya kompozit greft replasmanı olmak üzere aort kapak ameliyatı gerektirdi. Eşzamanlı kalp ameliyatları içinde en sık olan koroner arter baypas greftleme idi; Takayasu arteriti kaynaklı arteriyel greft patensi endişesi nedeniyle safen ven tercih edilen bir greft seçeneği idi. Ameliyat sonrası kardiyak komplikasyonlar 31 hastada (%20.7) oluştu ve 13'ünde (%41.9) yeniden girişim gerekti. Lojistik regresyon analizi ameliyat sonrası komplikasyonlar için belirleyici risk faktörlerinin primer aort kapak ameliyatı ve eşzamanlı kalp ameliyatı olduğunu ortaya koydu. Tüm hasta popülasyonun mortalite oranı %21.5 idi.So nuç: Takayasu arteriti aort regürjitasyonuna neden olabilir ve hastaların çoğunluğunda aort kapak ameliyatı gerekir. Ameliyat sonrası komorbidite oranı yüksektir. Ameliyat sonrası komplikasyonları ve sonraki yeniden girişimleri önlemek için aort kapak ameliyatları sırasında güçlendirici tekniklerden yararlanılması, Takayasu arteritinin aktif bir evresinde kardiyak ameliyatlardan kaçınılması ve ameliyat sonrası steroid tedavisi önerilmektedir.Anah tar söz cük ler: Aort regürjitasyonu; aort kapak replasmanı; Takayasu arteriti. ABSTRACTBackground: This study aims to describe the clinical features of aortic regurgitation, which can be a major complication of patients with Takayasu arteritis, as well as necessitated aortic valve operations in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aortic regurgitation and aortic valve operation in Takayasu arteritis: A meta-analysis

Yuan¹

2017

Turk Gogus Kalp Dama

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“…Subclavian and common carotid arteries are the most common sites [7]. Aortic regurgitation is found in 18% of patients, usually due to aortic root dilatation [8]. Pulmonary artery involvement is demonstrated in half of those patients [9].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Syncope in a Young Female with Incidental Long QTc Interval

Hanna

Lyon

Hawes

et al. 2015

Heart, Lung and Circulation

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“…In a series of 204 patients, active patients had a higher incidence of significant aortic valve regurgitation and pulmonary hypertension and higher levels of NTpro-brain natriuretic peptide (20). Active TAK patients also had more frequent involvement of the ascending aorta and the aortic arch and its main branches than the inactive group.…”

Section: Clinical Coursementioning

confidence: 98%

Recent advances in Takayasu's arteritis

Alıbaz-Öner¹,

Aydın²,

Direşkeneli³

2015

Eur J Rheumatol

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Takayasu's arteritis (TAK) is a rare, chronic large-vessel vasculitis (LVV) that predominantly affects the aorta, its major branches, and the pulmonary arteries. Recent advances in the diagnosis, clinical course, disease assessment with biomarkers/imaging and new clinical tools, patient-reported outcomes, and new treatment options of TAK are discussed in this review. Conventional angiography, the gold standard method for initial diagnosis, appears to have been replaced with new imaging modalities such as magnetic resonance angiography (MRA) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in recent years. MRA and FDG-PET are also promising for the assessment of disease activity. New tools for disease assessment such as Indian Takayasu's Arteritis Score 2010 (ITAS2010) and color Doppler ultrasound (CDUS) aim to better characterize and quantify disease activity; however, different imaging modalities in routine follow-up are not incorporated sufficiently in these approaches. Prognosis is possibly getting better, with lower mortality in recent years; however, it is difficult to assess the widely different vascular intervention rates among the clinical series. Leflunomide, tumor necrosis factor (TNF)-α antagonists, and tocilizumab are new options for patients resistant to conventional therapies. There is a clear need to develop a validated set of outcome measures for use in clinical trials of TAK. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group has taken on this task, finished a Delphi exercise with experts, and aims to develop a core set of outcomes for LVV in accordance with OMERACT Filter 2.0.

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Cardiovascular manifestations of Takayasu arteritis and their relationship to the disease activity: Analysis of 204 Korean patients at a single center

Cited by 144 publications

References 30 publications

Aortic regurgitation and aortic valve operation in Takayasu arteritis: A meta-analysis

Aortic regurgitation and aortic valve operation in Takayasu arteritis: A meta-analysis

An Unusual Case of Syncope in a Young Female with Incidental Long QTc Interval

Recent advances in Takayasu's arteritis

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