Recent advances in Takayasu's arteritis

Alıbaz-Öner, Fatma; Aydın, Sibel Zehra; Direşkeneli, Haner

doi:10.5152/eurjrheumatol.2015.0060

Cited by 37 publications

(18 citation statements)

References 72 publications

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“…TA is more prevalent in women of reproductive age, and clinical features usually reflect limb or organ ischemia that follow gradual stenosis of the involved arteries [78, 79]. …”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

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“…TA is more prevalent in women of reproductive age, and clinical features usually reflect limb or organ ischemia that follow gradual stenosis of the involved arteries [78, 79]. …”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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“…This systemic vasculopathy has a variable course ranging from a rapid progression in some patients to a late quiescent phase in others [14]. In up to 90% of cases there is involvement of the aorta, subclavian arteries, and carotid arteries, and angiographic features including stenosis, occlusion, dilatation, or aneurysm are pathognomonic [3, 15]. Diagnosis of TA is a challenge to practitioners worldwide largely due to its nonspecific presentation, multiorgan system involvement, and lack of diagnostic serologic tests.…”

Section: Discussionmentioning

confidence: 99%

“…Although such surgical and endovascular interventions have a potential for short-term benefits, failure and poorer outcomes, especially when they are undertaken during active inflammatory phase, are often reported [1]. Overall, the prognosis of TA is good with reported 5-year survival rates of 90% [13–15]. …”

Section: Discussionmentioning

confidence: 99%

Bilateral ocular ischemia-induced blindness as a presenting manifestation of Takayasu arteritis: a case report

Pallangyo¹,

Epafra²,

Nicholaus³

et al. 2017

J Med Case Reports

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BackgroundTakayasu arteritis is a granulomatous panarteritis that predominantly affects the aorta and its major branches. The initial manifestations of this large-vessel vasculitis are usually nonspecific; however, as the disease progresses, typical symptoms of arterial occlusion, aneurysmal formation, and vascular pain become evident. Ischemic ocular complications of Takayasu arteritis which could lead to complete loss of vision are not uncommon and depend on the obliterated portion(s) of carotid(s), the intensity and rate of progression of ocular vascular insufficiency, and sufficiency of the collateral blood supply to the eye.Case presentationA 24-year-old woman of African descent with prior normal vision was referred to us with a 3-year history of gradual decline in visual acuity in both eyes and unintentional weight loss (17 kg) within the past 1 year. A physical examination revealed feeble brachial and radial arterial pulses on her left side. She had sinus tachycardia (136 beats/minute) and her blood pressure was 85/59 mmHg on her left and 134/82 mmHg on her right side. Bilateral microaneurysms, dot and blot hemorrhages, and multiple ischemic areas of retina together with neovascularization in her right eye were noted during a funduscopic examination. Computed tomography angiography of her thoracic and abdominal aorta revealed irregular narrowing with variable degrees of stenosis, tapering, and corrugated appearance.ConclusionsDespite its rarity, Takayasu arteritis significantly impairs a patient’s quality of life and has a life-threatening potential. Early initiation of appropriate therapy could delay disease progression and reduce the associated complications.

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“…Дополнительную информацию о состоянии стенок аорты и признаках воспаления получают при радиоизотопном исследовании с Gd 64 или при пози-тронно-эмиссионной томографии с [18F]-фтордезоксиглюкозой. Известно, что результаты лабораторных исследований с повышением уровня многих показателей (скорость оседания эритроцитов, С-реактивный белок, Д-димеры, активность тромбоцитов и содержание фибринопептида-А) характерны для васкулита Takayasu [33].…”

Section: Fibromuscular Dysplasia Of the Coronary Arteries фибромускулunclassified

Modern Concepts of Fibromuscular Dysplasia of the Coronary Arteries

Трисветова

2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Fibromuscular dysplasia of the coronary arteries is a rare non-atherosclerotic and non-inflammatory vascular lesion that is asymptomatic until serious complications develop: stenosis, dissection, rupture, sudden cardiac death. Since there are no long-term numerous clinical observations of patients with fibromuscular dysplasia of the coronary arteries, recommendations have not been developed for diagnosing and treating the disease, which often manifests with acute coronary syndrome. In 2014, the European Consensus was published, and in 2019, the first international consensus document on the diagnosis and treatment of fibromuscular dysplasia with lesions of vessels from different regions (renal, cerebrovascular, coronary, and others). The documents state that the development of fibromuscular dysplasia of the coronary arteries considers the participation of the PHACTR1 gene mutation and the transcriptional activity of the EDN1 gene, smoking, prolonged exertion of the vascular wall, and possibly female sex hormones. In the case of acute coronary syndrome, the most informative diagnostic method is computed tomography with angiography, which reveals a smooth narrowing of the lumen in the middle or distal section in the epicardial artery, often due to intramural hematoma, and also finds dissection, spasm, and tortuous vessel. Additional diagnostic methods ‒ intravascular ultrasound and optical coherence tomography allow differentiation of fibromuscular dysplasia with atherosclerosis of the coronary artery, vasculitis, and other diseases. The choice of treatment tactics for fibromuscular dysplasia of the coronary arteries depends on the severity of the clinical manifestations ‒ conservative medical treatment and interventional methods are used.

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Recent advances in Takayasu's arteritis

Cited by 37 publications

References 72 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Bilateral ocular ischemia-induced blindness as a presenting manifestation of Takayasu arteritis: a case report

Modern Concepts of Fibromuscular Dysplasia of the Coronary Arteries

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