Cardiovascular Magnetic Resonance Imaging and Heart Failure

Liu, Chuan‐Fen; Ferrari, Victor A.; Han, Yuchi

doi:10.1007/s11886-021-01464-9

Cited by 17 publications

(18 citation statements)

References 203 publications

(77 reference statements)

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“…New MRI T 1 mapping sequences, based on Look and Locker schemes of saving time in NMR relaxation measurements, are now available on clinical MRI scanners and used for mapping of native T 1 in myocardium 59 . Sequences such as modified Look–Locker imaging (MOLLI) 60 and saturation‐recovery single‐shot acquisition (SASHA) 61 offer a drastic reduction in T 1 mapping with a slight decrease in accuracy 62,63 . The use of newly developed variants of fast imaging sequences with variable flip angle and variable TR deliver other options for the rapid and more accurate T 1 mapping 64–67 .…”

Section: Discussionmentioning

confidence: 99%

Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

2021

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Purpose: One standard method, proton resonance frequency shift, for measuring temperature using magnetic resonance imaging (MRI), in MRI-guided surgeries, fails completely below the freezing point of water. Because of this, we have developed a new methodology for monitoring temperature with MRI below freezing. The purpose of this paper is to show that a strong temperature dependence of the nuclear relaxation time T 1 in soft silicone polymers can lead to temperature-dependent changes of MRI intensity acquired with T 1 weighting. We propose the use of silicone filaments inserted in tissue for measuring temperature during MRI-guided cryoablations. Methods: The temperature dependence of T 1 in bio-compatible soft silicone polymers was measured using nuclear magnetic resonance spectroscopy and MRI. Phantoms, made of bulk silicone materials and put in an MRI-compatible thermal container with dry ice,allowed temperature measurements ranging from -60 • C to + 20 • C. T 1 -weighted gradient echo images of the phantoms were acquired at spatially uniform temperatures and with a gradient in temperature to determine the efficacy of using these materials as temperature indicators in MRI. Ex vivo experiments on silicone rods, 4 mm in diameter, inserted in animal tissue were conducted to assess the practical feasibility of the method. Results: Measurements of nuclear relaxation times of protons in soft silicone polymers show a monotonic, nearly linear, change with temperature (R 2 > 0.98) and have a significant correlation with temperature (Pearson's r > 0.99, p < 0.01). Similarly, the intensity of the MR images in these materials, taken with a gradient echo sequence, are also temperature dependent. There is again a monotonic change in MRI intensity that correlates well with the measured temperature (Pearson's r < -0.98 and p < 0.01). The MRI experiments show that a temperature change of 3 • C can be resolved in a distance of about 2.5 mm. Based on MRI images and external sensor calibrations for a sample with a gradient in temperature, temperature maps with 3 • C isotherms are created for a bulk phantom. Experiments demonstrate that these changes in MRI intensity with temperature can also be seen in 4 mm silicone rods embedded in ex vivo animal tissue. Conclusions: We have developed a new method for measuring temperature in MRI that potentially could be used during MRI-guided cryoablation operations, reducing both procedure time and cost, and making these surgeries safer.

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Section: Discussionmentioning

confidence: 99%

Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

2021

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“…CMR has an important role in patients presenting with unexplained HF and those with an infarct-like presentation with non-obstructive CAD. Its ability of tissue characterization can help in revealing the underlying etiology and sometimes offer some prognostic information [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical course, viral etiology, and the diagnostic workup for patients with suspected myocarditis: a single-center prospective study

Khidr

El‐Mokhtar

Asaad

et al. 2022

BMC Cardiovasc Disord

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Background Myocarditis is a highly heterogeneous disorder with a challenging diagnostic work-up. We aimed to focus on the possible diagnostic workup for this condition in settings where endomyocardial biopsy as a gold standard is not always feasible, detect the etiologic cardiotropic viruses in our locality, and follow the clinical course in patients admitted with clinically suspected myocarditis. Methods This is a prospective observational study. We recruited patients with clinically suspected myocarditis presenting at a university hospital from October 1st, 2020 until March 31st, 2021. All Patients had a diagnostic coronary angiography and were included only if they had a non-obstructive coronary artery disease. All patients also had cardiac magnetic resonance imaging (CMR) with contrast. Sera were obtained from all suspected patients for detection of antibodies against viruses using enzyme-linked immunosorbent assay, and viral genomes using polymerase chain reaction (PCR), and reverse transcription–PCR. Endomyocardial biopsy was done for patients with a typical CMR picture of myocarditis. Results Out of 2163 patients presenting to the hospital within the 6 months, only 51 met the inclusion criteria. Males represented 73%, with a mean age of 39 ± 16 years. CMR showed an ischemic pattern in 4 patients and thus they were excluded. We classified patients into two categories based on CMR results: group A (CMR-positive myocarditis), 12 patients (25.5%), and group B (CMR-negative myocarditis), 35 (74.5%) patients. On serological analysis, 66% of patients (n = 31/47) showed antibodies against the common cardiotropic viruses. Parvovirus B19 IgM in 22 patients (47%) and coxsackievirus IgM in 16 (34%) were the most observed etiologies. Regarding the outcome, 42.5% of patients recovered left ventricular ejection fraction and three patients died at 6 months’ clinical follow-up. Conclusion Patients with Clinically suspected myocarditis represented 2.2% of total hospital admissions in 6 months. CMR is only a good positive test for the diagnosis of acute myocarditis. Parvovirus B19 and coxsackievirus were the most common pathogens in our locality. Trial registration: Clinical trial registration no., NCT04312490; first registration: 18/03/2020. First recruited case 01/10/2020. URL: https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009O3D&selectaction=Edit&uid=U0002DVP&ts=2&cx=9zdfin.

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“…Finally, new advances in edema weighted imaging, T1 and T2 mapping, fingerprinting and three-dimensional imaging all add to the diagnostic and prognostic utility of CMR in heart failure evaluation [51]. The utility of CMR is likely to further grow over time as these advances are incorporated into more routine clinical practice, and the ability of CMR to simultaneously answer multiple different clinical questions for heart failure patients will further speed its growth.…”

Section: Cardiac Magnetic Resonancementioning

confidence: 99%

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction

Hassan

Higgins

2022

Current Opinion in Cardiology

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Purpose of reviewThe burden of clinical heart failure, both heart failure with a reduced ejection fraction (HFrEF) and with a preserved ejection fraction (HFpEF), continues to increase both nationally and globally. This review summarizes the expanding role of multimodality imaging techniques in the evaluation and management these patients. Recent findingsEchocardiographic assessment for heart failure continues to expand and should include a robust hemodynamic and strain assessment. Nuclear techniques have also continued to evolve and advances including computed tomography attenuation correction for single photon emission-computed tomography positron-emission tomography increase diagnostic accuracy as well as provide information such as myocardial blood flow and viability assessment. Computed tomography imaging, already well established in the assessment of coronary and valvular disease, has increasing utility in the characterization of myopathy, and cardiac magnetic resonance imaging (MRI) continues to expand its role in tissue characterization to a wider breadth of diseases, including right ventricular cardiomyopathy and left ventricle noncompaction.

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Cardiovascular Magnetic Resonance Imaging and Heart Failure

Cited by 17 publications

References 203 publications

Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

Clinical course, viral etiology, and the diagnostic workup for patients with suspected myocarditis: a single-center prospective study

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction

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Cardiovascular Magnetic Resonance Imaging and Heart Failure

Cited by 17 publications

References 203 publications

Measurement of sub‐zero temperatures in MRI using T1 temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

Measurement of sub‐zero temperatures in MRI using T1 temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

Clinical course, viral etiology, and the diagnostic workup for patients with suspected myocarditis: a single-center prospective study

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction

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Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery

Measurement of sub‐zero temperatures in MRI using T₁ temperature sensitive soft silicone materials: Applications for MRI‐guided cryosurgery