Cardiovascular health and the menopause: the gynecologist as the patients' interface

Rd, Arias

doi:10.1080/13697130600916148

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…Furthermore, considerable evidence has suggested the association between sleep disorder with menopause 3, 15 , arterial stiffness with menopause 16 , sleep disorder with arterial stiffness 11–13 . However, few corresponding researches were focusing on the interaction with menopause, sleep disorder and arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…Besides vasomotor symptoms (VMS), such as hot flushes/night sweats, sleep disorder is also one of the most common menopausal symptoms affecting about 50% to 80% of middle-aged women 2 . Additionally, menopause makes women more subjected to higher incidence of cardiovascular morbidity and mortality in the long run 3 .…”

Section: Introductionmentioning

confidence: 99%

“…As the burden of cardiovascular diseases (CVD) in women after menopause is increasing 3 , highlighting the need for middle-aged women-based research designed to disentangling the complex interactions among sleep disorder, menopause and cardiovascular health.…”

Section: Introductionmentioning

confidence: 99%

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Sleep disorder, an independent risk associated with arterial stiffness in menopause

Zhou

Yang

et al. 2017

Sci Rep

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As women age and go through menopause, they suffer a higher incidence of sleep disorder, cardiovascular morbidity and mortality. In addition, evidences suggested that sleep disorder was an important pathological indicator for coronary heart disease. However, the relationship between different menopausal status, sleep disorder and cardiovascular diseases was unclear. Thus, we aim to assess the association between sleep disorder with arterial stiffness in females of 40–60 years free of cardiovascular diseases through self-administered Pittsburgh Sleep Quality Index (PSQI) and brachial-ankle pulse wave velocity (baPWV). Logistic regression revealed that sleep disorder (PSQI score ≥ 8) was an independent indicator for higher risk of elevated arterial stiffness (baPWV ≥ 1465.5 cm/s, upper tertile) beyond other established cardiovascular confounders in peri-postmenopause (OR 2.83, 95% confidence interval (CI) 2.00–4.00, p < 0.001), but not in premenopause (OR 1.67, 95% CI 0.71–3.90, p = 0.223). Collectively, it clearly indicates that sleep disorder in menopausal women is of prominent value to predict arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep disorder, an independent risk associated with arterial stiffness in menopause

Zhou

Yang

et al. 2017

Sci Rep

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“…However, ERT also shows undesirable side effects including increased incidence of breast cancer and heart disease. 12) Recently, there has been growing interest in searching for alternatives from dietary natural plant products.…”

Section: Discussionmentioning

confidence: 99%

Effects of Metabolites of the Lignans Enterolactone and Enterodiol on Osteoblastic Differentiation of MG-63 Cells

Feng

Shi

2008

Biological & Pharmaceutical Bulletin

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The role of estrogens and estrogen-like molecules in regulating bone cell activities is central to understanding the etiology and treatment of postmenopausal osteoporosis. 1,2) In the past few years, natural estrogen-like molecules, the phytoestrogens, have attracted attention for their potential roles in osteoporosis prevention and treatment. 3) In contrast to the isoflavone-type phytoestrogens such as genistein, lignan-type phytoestrogens have rarely been studied, although they are widely distributed in the plant kingdom. Cereals, grains, berries, and garlic are good dietary sources of lignans. Recently, lignans have received considerable attention for their potential role in the prevention of osteoporosis.4) Lignans are metabolized into the more biologically active mammalian lignans enterodiol and enterolactone by microbiota in the colon. 5)Osteoblasts play a crucial role in bone formation through proliferation and differentiation. Osteoblast differentiation, an important process for its function, confers marked rigidity and strength on bone while still maintaining some degree of elasticity. Thus stimulation of osteoblast differentiation has been suggested to be an important therapeutic approach for the prevention and treatment of bone disease such as osteoporosis.6,7) While the isoflavone genistein 8) and arylnaphthalene-type lignans 9) have been shown to increase the differentiation of osteoblast-like cells, the effect of enterolignans, enterodiol and enterolactone, are unknown. Therefore we carried out the present research to determine whether enterodiol and enterolactone ( Fig. 1) have stimulatory effects on osteoblast differentiation. MATERIALS AND METHODSCell Culture MG-63 cells (purchased from the American Type Culture Collection), a human osteoblast-like cell line, were used to assess the cellular responses to enterolignans. Cells were cultured in 25 cm 2 flasks in Dulbeco's modified Eagle's medium (DMEM, Gibco) containing 10% heatinactivated fetal bovine serum, L-glutamine 2 mM, penicillin 100 U/ml, and streptomycin 100 mg/ml. Cultures were maintained at 37°C in a humidified atmosphere containing 5% CO 2 . When digested, the cells were washed with phosphatebuffered saline (PBS, Gibco), detached with trypsin-EDTA solution (0.25% trypsin, Gibco) at 37°C for 5 min, centrifuged, and resuspended for further cell tests.Cytotoxicity Assay Following incubation of cells with enterolactone and enterodiol (purchased from Sigma) for specified times in 96-well plates, 20 ml of PBS containing 5 mg/ml of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT, Sigma) was added to each well. Plates were incubated at 37°C for 4 h, then the medium was replaced with 150 ml of dimethyl sulphoxide (DMSO, Sigma). After 10-min incubation, absorbance in control and treated wells was measured in a plate reader at 490 nm.Alkaline Phosphotase Test Alkaline phosphotase (ALP) activity was measured colorimetrically using disodium phenyl phosphate as the substrate. The enzyme ALP expressed by the cells hydrolyzed the su...

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“…Although diabetes itself is a strong risk factor for CHD, other traditional (age, race, smoking, BMI, LDL and HDL cholesterol, hypertension) and non‐traditional (albumin, fibrinogen, von Willebrand factor, factor VIII activity, and leukocyte count) risk factors are also associated with CHD in diabetic individuals 5, 6. In addition, over recent decades, case–control and cohort studies have found that family history of CHD is a risk factor for incident CHD 7–16, and the postmenopausal state is a unique CHD risk factor for women 17–20. However, whether family history of CHD independently predicts CHD in postmenopausal women with diabetes remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study

OʼSullivan

Robinson

et al. 2009

Diabetes Metabolism Res

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Background Diabetes is a risk factor for coronary heart disease (CHD) but CHD does not occur in all diabetic individuals. The goal of this study was to assess the relationship between family history of myocardial infarction (MI) and incident CHD in diabetic postmenopausal women. Methods We conducted a prospective cohort study among 2642 diabetic postmenopausal women without CHD at baseline in the Women’s Health Initiative Observational Study. Family history was defined as a proband report of MI in first-degree relatives. Incident CHD was defined as non-fatal MI, coronary revascularization, or CHD death. Results During 7.3 (±1.8) years of follow-up, 14.3% of the participants had incident CHD. The risk of incident CHD was 50% higher (HR = 1.50, 95% CI: 1.20–1.87, p = 0.0003) in those with a family history of an MI in at least one first-degree relative, and 79% higher (HR = 1.79, 95% CI: 1.36–2.35, P < 0.0001) if two or more first-degree relatives had an MI, compared to participants without a family history, after adjustment for covariates. The CHD risk increased with elevated systolic blood pressure (SBP) (HR = 1.01, 95% CI: 1.003–1.02, p = 0.001) but decreased with elevated diastolic BP (HR = 0.98, 95% CI: 0.97–0.999, p = 0.005) and with two or more episodes per week of physical activity (HR = 0.70, 95% CI: 0.52–0.93, p = 0.02). Conclusions The results suggest that a family history of MI predicts CHD in diabetic postmenopausal women. Close attention should be paid to BP control and physical activity in these women.

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Cardiovascular health and the menopause: the gynecologist as the patients' interface

Cited by 6 publications

References 55 publications

Sleep disorder, an independent risk associated with arterial stiffness in menopause

Sleep disorder, an independent risk associated with arterial stiffness in menopause

Effects of Metabolites of the Lignans Enterolactone and Enterodiol on Osteoblastic Differentiation of MG-63 Cells

Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study

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