Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats

Almeida, Flávio; Perry, Juliana C.; Futuro-Neto, H. A.; Almeida, Vitória de Cássia Félix de; Sebastião, R M; Andersen, Mônica Levy; Tufik, Sérgio; Campos, Rui; Bergamaschi, Cássia T.

doi:10.3109/10641963.2014.881843

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…The other study demonstrated that OSAS is the most common secondary etiology in patients with resistant hypertension [22]. Consistent with the present study, previous experimental studies also reported that acute REM sleep deprivation is associated with arterial hypertension [23,24]. Increase of sympathetic nervous system (SNS) activity, increase of vascular resistance, activation of the renin-angiotensin-aldosterone system, and increase of arterial stiffness following sleep loss and hypoxemia are some involving factors in this type of hypertension [25][26][27].…”

Section: Discussionsupporting

confidence: 88%

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

Joukar

Ghorbani-Shahrbabaki

2015

Sleep Breath

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Purpose Some of the previous studies have used animal model of paradoxical sleep deprivation for investigation of sleep loss complications. The present study is designed to examine the effectiveness and reliability of this model for investigation and assessment of some cardiovascular complications of obstructive sleep apnea syndrome. Methods The Wistar rat groups were divided into the control group, the Test48 and Test72 groups, who experienced paradoxical sleep deprivation for 48 and 72 h, and the Sham48 and Sham72 groups, who were exposed to environmental conditions same to test groups but without sleep deprivation, respectively. At the end of the experiment, blood pressure and heart rate variability were assessed. ResultsThe results showed that 72 h rapid eye movements sleep deprivation significantly increased the systolic blood pressure compared to the control (p < 0.01), Sham48 and Test48 groups (p < 0.05). The comparison of the heart rate and heart rate variability parameters such as time domain indices (RR interval, SDNN, RMSSD, SD1, SD2, and SD1/ SD2) as well as frequency-domain variables (total power, LF and HF power, and LF/HF) had no significant difference among animal groups. Conclusions These findings suggest that rat paradoxical sleep deprivation may be a suitable model for induction and investigation of hemodynamic alterations which occurs in obstructive sleep apnea syndrome; however, it cannot be an alternative model to induce heart rate variability alterations similar to those reported in patient with obstructive sleep apnea.

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Section: Discussionsupporting

confidence: 88%

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

Joukar

Ghorbani-Shahrbabaki

2015

Sleep Breath

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“…According to Kato et al, after one night of sleep deprivation the arterial blood pressure increases and muscle sympathetic nerve activity decreases [24]. Other studies realized by Almeida FR et al suggest that acute paradoxical sleep loss (REM sleep) induces autonomic imbalance expressed by impaired baroreflex sensitivity, cardiovascular disfunctions, increased arrhythmia susceptibility and also changes related to oxidative stress or other cerebral pathologies [25][26][27]. The variation of arterial blood pressure in our study can be associated with the alteration of baroreflex sensitivity.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Caffeine Intake on Cardiovascular Parameters in Sleep Deprived Medical Residents

Papacocea¹,

Bădărău²,

Ciornei³

et al. 2019

Rev. Chim.

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Physicians and medical residents are particularly affected by sleep deprivation are, especially in East European countries. The aim of our study is to analyze the effect of caffeine intake on cardiovascular functions in sleep deprived residents (clinicians in-training) after continuous 24h on-call duty. 26 medical residents aged between 22-33 years old, 12 men and 14 women, who began their activity at 2 pm were included. Each subject consumed coffee or caffeinated drinks such as Coca cola during this period, after 2 am, expressed in caffeine units. We have evaluated their cardiovascular function using impedance cardiography (ICG-M501) and blood pressure measurement using the manometric method, before (at 7 pm) and after caffeine consumption (at 7 am), during one night of on-call duty. Surprisingly, after caffeine consumption, all subjects have had a decrease of the heart rate after one night of sleep deprivation (from mean: 83 b/min before to 69.73 b/min after, p = 0.000), also the mean arterial blood pressure is lower after the overnight call (from mean: 95.3 mmHg before to 88.9 mmHg after). Moreover, cardiac output, stroke volume and cardiac index decreases along with an increase of peripheral vascular resistance. Caffeine intake exerts a paradoxical effect on sleep deprived subjects; acute sleep loss, due to continuously, intense on-call work, modifies several cardiovascular parameters, such as heart rate, blood pressures, stroke volume and cardiac output.

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“…Pre-ischemic and reperfusion HR were higher in the SD group than in controls, which is consistent with the reports by others. Sgoifo et al, 19 Carvalho et al, 20 and Almeida et al 21 have reported that SD rats exhibited an increased HR and were vulnerable to ventricular arrhythmias. The mechanism of action of SD on HR during perfusion and reperfusion is not completely understood.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Sleep Deprivation on Cardiac Function and Tolerance to Ischemia-Reperfusion Injury in Male Rats

Jeddi

Asl

Asgari

et al. 2015

Arquivos Brasileiros De Cardiologia

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BackgroundSleep deprivation (SD) is strongly associated with elevated risk for cardiovascular disease.ObjectiveTo determine the effect of SD on basal hemodynamic functions and tolerance to myocardial ischemia-reperfusion (IR) injury in male rats.MethodSD was induced by using the flowerpot method for 4 days. Isolated hearts were perfused with Langendorff setup, and the following parameters were measured at baseline and after IR: left ventricular developed pressure (LVDP); heart rate (HR); and the maximum rate of increase and decrease of left ventricular pressure (±dp/dt). Heart NOx level, infarct size and coronary flow CK-MB and LDH were measured after IR. Systolic blood pressure (SBP) was measured at start and end of study.ResultsIn the SD group, the baseline levels of LVDP (19%), +dp/dt (18%), and -dp/dt (21%) were significantly (p < 0.05) lower, and HR (32%) was significantly higher compared to the controls. After ischemia, hearts from SD group displayed a significant increase in HR together with a low hemodynamic function recovery compared to the controls. In the SD group, NOx level in heart, coronary flow CK-MB and LDH and infarct size significantly increased after IR; also SD rats had higher SBP after 4 days.ConclusionHearts from SD rats had lower basal cardiac function and less tolerance to IR injury, which may be linked to an increase in NO production following IR.

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Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats

Cited by 18 publications

References 28 publications

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

The Effects of Caffeine Intake on Cardiovascular Parameters in Sleep Deprived Medical Residents

The Effect of Sleep Deprivation on Cardiac Function and Tolerance to Ischemia-Reperfusion Injury in Male Rats

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