2016
DOI: 10.1155/2016/4106502
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Cardiovascular Effects of the Essential Oil of Croton argyrophylloides in Normotensive Rats: Role of the Autonomic Nervous System

Abstract: Cardiovascular effects of the essential oil of Croton argyrophylloides Muell. Arg. (EOCA) were investigated in normotensive rats. In saline-pretreated anesthetized or conscious rats, intravenous (i.v.) injection of the EOCA induced dose-dependent hypotension. Dose-dependent tachycardia was observed only in conscious rats. In anesthetized rats, cervical bivagotomy failed to enhance EOCA-induced hypotension but unmasked significant bradycardia. In conscious rats, i.v. pretreatment with methylatropine, but not wi… Show more

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Cited by 7 publications
(10 citation statements)
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References 32 publications
(44 reference statements)
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“…This arterial catheter allows us to record the arterial blood pressure. For systemic drug administration, the inferior vena cava was cannulated through the left femoral vein as previously described (Alves-Santos et al, 2016). After surgical procedure, all animals received an intramuscular injection of penicillin (24,000 IU), then housed individually in plastic cages and allowed to recover for 24 h before any circulatory experiments.…”
Section: Methodsmentioning
confidence: 99%
“…This arterial catheter allows us to record the arterial blood pressure. For systemic drug administration, the inferior vena cava was cannulated through the left femoral vein as previously described (Alves-Santos et al, 2016). After surgical procedure, all animals received an intramuscular injection of penicillin (24,000 IU), then housed individually in plastic cages and allowed to recover for 24 h before any circulatory experiments.…”
Section: Methodsmentioning
confidence: 99%
“…Likewise, P. asiatica EO also modulated mRNA and protein expression of LDL receptor and HMG-CoA reductase in HepG2 cells [31]. [32][33][34][35][36][37]. Particularly, C. argyrophylloides EO induced a dosedependent aortic relaxation (IC 50 , ~25 μg/mL) that was associated with muscarinic receptor stimulation as well as liberation of the endotheliumderived prostacyclin whereby in experimented condition, its activity was greatly lowered by pre-treatment with anti-muscarinic agent (e.g 1 μM atropine, IC 50 increase to ~197 μg/mL) [36].…”
Section: Several In Vitro Studiesmentioning
confidence: 95%
“…[32][33][34][35][36][37]. Particularly, C. argyrophylloides EO induced a dosedependent aortic relaxation (IC 50 , ~25 μg/mL) that was associated with muscarinic receptor stimulation as well as liberation of the endotheliumderived prostacyclin whereby in experimented condition, its activity was greatly lowered by pre-treatment with anti-muscarinic agent (e.g 1 μM atropine, IC 50 increase to ~197 μg/mL) [36]. Its action was also affected by cyclooxygenase blocker (e.g at 10 μM indomethacin, IC 50 increase to ~91 μg/mL), vascular endothelium removal (at IC 50 increase to ~76 μg/mL) and anti-diabetic agent (e.g at 100 μM glibenclamide, IC 50 increase to ~64 μg/mL) [36].…”
Section: Several In Vitro Studiesmentioning
confidence: 99%
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