Cardiovascular effects of the essential oil of Croton zehntneri leaves and its main constituents, anethole and estragole, in normotensive conscious rats

Siqueira, Rodrigo José Bezerra de; Magalhães, Pedro Jorge Caldas; Leal-Cardoso, José Henrique; Duarte, Glória Pinto; Lahlou, Saad

doi:10.1016/j.lfs.2005.09.042

Cited by 58 publications

(63 citation statements)

References 20 publications

(24 reference statements)

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“…In fact, this contraction was significantly less when the endothelium was intact, compared to denuded tissues, and not greater in the presence of L-NAME/ indomethacin combination. A recent study of the cardiovascular effects of the essential oil of Croton zehntneri, of which approximately 90% is anethole and estragole, has shown biphasic effects on blood pressure, whilst in vitro experiments indicated an initial contractile effect of the oil followed by relaxation of precontracted rat aorta at higher doses (de Siqueira et al, 2006). The authors found that the contractile effect of the essential oil was inhibited by L-NAME and concluded that the vasoconstrictor effect was due to an inhibition of endothelial nitric oxide production.…”

Section: Discussionmentioning

confidence: 99%

Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

et al. 2007

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“…In skeletal muscle, we observed that EOCz and AT blocked the excitation-contraction coupling, released Ca þ þ from the sarcoplasmic reticulum and induced contraction (Albuquerque et al, 1995). In the cardiovascular system, our group found that EOCz treatment induced an initial hypotension followed by a pressor response in normal conscious rats, whereas it induced a bradycardia accompanied by a depressor reflex in anaesthetised rats, which appears to be mediated by the activation of vallinoid TPRV1 receptors located on the sensory vagal nerves (Lahlou et al, 1999;de Siqueira et al, 2006).…”

Section: Introductionmentioning

confidence: 92%

The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing

Cavalcanti

Leal-Cardoso

Diniz

et al. 2012

Journal of Ethnopharmacology

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“…al., 2008), as atividades anti-helmíntica e efeito cardiovascular do Croton zehntneri (Camurça-Vasconcelos et al, 2007, De Siqueira et al, 2006, antinociceptiva do Croton urucurana (Rao et al, 2007), moluscicida do Croton campestris (Babili et al, 2006), anti-inflamatória do Croton cuneatus (Suárez et al, 2006), e mutagênica e antioxidante do Croton lechleri (Lopes e Lopes et al, 2004).…”

Section: Abstract: Medicinal Plants;unclassified

Atividade antimicrobiana dos extratos metanólicos da raiz, caule e folhas de Croton pulegioides Baill. (Zabelê)

Arrais

Lyra

et al. 2014

Rev. bras. plantas med.

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RESUMO: O uso popular de plantas medicinais continua sendo de grande interesse para a população, principalmente em países em desenvolvimento, nos quais o acesso à medicina alopática ainda é muito restrito. Assim, além de sua importância na medicina tradicional, o conhecimento das plantas pode fornecer para a indústria farmacêutica, direta ou indiretamente, princípios ativos de interesse terapêutico. No presente trabalho foi avaliada a atividade antimicrobiana dos extratos metanólicos secos de Croton pulegioides Baill. obtidos a partir da raiz, do caule e das folhas nas concentrações de 25, 50 e 100mg/mL utilizando o método de difusão em Agar (técnica de poços) frente a cinco cepas Gram-positivas, três cepas de fungos e três cepas de bactérias Gram-negativas. Na execução do estudo foi utilizado o antibiótico Gentamicina (100µg/mL) no teste com bactérias, e Cetoconazol (300µg/mL) para as Candidas verificando-se, ao mesmo tempo, a ausência de atividade para o diluente DMSO 20% em água. Na observação dos resultados evidenciaram-se halos de inibição indicando atividade dos extratos metanólicos da raiz, caule e folhas, nas concentrações de 50 e 100mg/ml, frente Bacillus subtilis AM 04; dos extratos metanólicos da raiz e do caule, nas concentrações de 50 e 100mg/ml, frente Staphylococcus aureus AM 103 (ATCC 6538); e do extrato metanólico do caule, nas concentrações de 50 e 100mg/ml, frente S. epidermidis AM 235. Por outro lado, todos os extratos foram inativos nas concentrações avaliadas frente às bactérias Gram-negativas utilizadas no estudo (Pseudomonas aeruginosa AM 206, Escherichia coli AM 1050 e Klebsiella pneumoniae AM 410). Referente à atividade sobre fungos, os extratos metanólicos da raiz e do caule inibiram, nas três concentrações avaliadas, o crescimento de Candida tropicalis AM 1181 e C. albicans AM 1140, enquanto o extrato das folhas, inibiu o crescimento de C. tropicalis AM 1181 nas concentrações de 50 e 100mg/ml e de C. albicans AM 1140 apenas na concentração de 100mg/mL. Finalmente o extrato metanólico das folhas, na concentração de 100mg/mL, foi o único a inibir o crescimento de Candida krusei. Os resultados preliminares apresentados pelo presente trabalho sugeriram que a espécie Croton pulegioides Baill. apresentou resultados promissores quanto ao potencial antimicrobiano. Palavras-chave:Plantas medicinais, Croton pulegioides Baill., Atividade antimicrobiana.ABSTRACT: Antimicrobial activity of methanol extracts of root, stem and leaves of Croton pulegioides Baill. The employment of medicinal plants as a folk custom remains important to the present time, mainly in developing countries, where access to allopathic medicine is restricted. Besides their importance in traditional medicine, the knowledge on these plants can, directly or indirectly, provide information about the active ingredients involved, which may be of interest to the pharmaceutical industry. The present study evaluated the antimicrobial activity of dried methanolic extracts of Croton pulegioides Baill, extracted from its roots, stalk, an...

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Cardiovascular effects of the essential oil of Croton zehntneri leaves and its main constituents, anethole and estragole, in normotensive conscious rats

Cited by 58 publications

References 20 publications

Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing

Atividade antimicrobiana dos extratos metanólicos da raiz, caule e folhas de Croton pulegioides Baill. (Zabelê)

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