Cardiovascular effects of romifidine in the standing horse

Freeman, Sarah; Bowen, Mark; Bettschart‐Wolfensberger, Regula; Alibhai, Hatim; England, G. C. W.

doi:10.1053/rvsc.2001.0533

Cited by 47 publications

(59 citation statements)

References 12 publications

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“…Cardiac and vascular modifications were similar to those reported in previous studies (Wagner et al 1991;England et al 1992;Bueno et al 1999;Freeman et al 2002); bradycardia, atrio-ventricular blocks, bradypnea and pressure modifications were observed. On the whole, the major alterations were detected in group D, followed by R and X, but with a lower intensity to that reported in the literature, maybe because of the lower dosage given (Wagner et al 1991;Yamashita et al 2000).…”

Section: Discussionsupporting

confidence: 90%

The Use of Alpha-2 Agonists in the Equine Practice: Comparison between Three Molecules

et al. 2007

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Section: Discussionsupporting

confidence: 90%

The Use of Alpha-2 Agonists in the Equine Practice: Comparison between Three Molecules

et al. 2007

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“…A significant increase in ½HCO À 3 std B was observed for both alpha 2 -adrenergic agonists. Similar effects on HCO À 3 and BE have been observed after single doses of romifidine (Freeman et al, 2002;Wojtasiak-Wypart et al, 2012) or during medetomidine or detomidine CRI (Daunt et al, 1993;Bettschart-Wolfensberger et al, 1999;Solano et al, 2009) in horses. Unfortunately blood lactate was not measured in the present study.…”

Section: Discussionsupporting

confidence: 56%

“…However pH values remained within physiologically normal limits. An increase in pH has not been reported previously after single doses of the different alpha 2 -adrenergic agonists (Clarke et al, 1991;Bueno et al, 1999;Yamashita et al, 2000;Freeman et al, 2002;Bettschart-Wolfensberger et al, 2005) or during CRI of medetomidine and detomidine (Daunt et al, 1993;Bettschart-Wolfensberger et al, 1999;van Dijk et al, 2003) in horses. Conversely, a decrease in pH in face of an increase in HCO À 3 was reported during a CRI of medetomidine-morphine (Solano et al, 2009).…”

Section: Discussionmentioning

confidence: 78%

Blood glucose, acid–base and electrolyte changes during loading doses of alpha2-adrenergic agonists followed by constant rate infusions in horses

Ringer¹,

Schwarzwald²,

Portier³

et al. 2013

The Veterinary Journal

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The aim of the present study was to investigate changes in blood glucose concentration ([Glu]B), acid-base status and electrolyte concentrations during constant rate infusions (CRI) of two alpha2-adrenergic agonists in seven horses treated in a blinded, randomised, crossover design with xylazine or romifidine. An intravenous (IV) bolus of xylazine (1mg/kg) or romifidine (80g/kg) was administered followed by an IV CRI of xylazine (0.69mg/kg/h) or romifidine (30g/kg/h) for 2h. Blood samples were collected from the pulmonary artery before and after loading doses, during the CRI, and for 1h after discontinuing drugs. Blood glucose, base excess (BE), pH, partial pressure of carbon dioxide (Pv¯CO2), strong ion difference (SIDest) and bicarbonate concentration ( [Formula: see text] ) increased significantly during the CRI with both alpha2-adrenergic agonists. Chloride concentration ([Cl-]B) and anion-gap (AG) decreased significantly compared to baseline. The decrease in sodium concentration ([Na+]B) was only significant with xylazine. From 1h after starting the CRI onwards, [Glu]B was significantly higher with romifidine compared to xylazine. Except [Glu]B, SIDest, and Pv¯CO2, all variables returned to normal values 1h after discontinuing xylazine. After stopping romifidine, all variables except pH remained altered for at least 1h. It was concluded that loading doses of alpha2-adrenergic agonists followed by CRIs produce [Glu]B, acid-base and electrolyte changes. The clinical significance of the reported changes remains to be investigated and absolute values should be interpreted with caution, as fluid boli were used for cardiac output measurements, but may become important during prolonged infusion and in critically ill patients. a b s t r a c tThe aim of the present study was to investigate changes in blood glucose concentration ([Glu] B ), acidbase status and electrolyte concentrations during constant rate infusions (CRI) of two alpha 2 -adrenergic agonists in seven horses treated in a blinded, randomised, crossover design with xylazine or romifidine.An intravenous (IV) bolus of xylazine (1 mg/kg) or romifidine (80 lg/kg) was administered followed by an IV CRI of xylazine (0.69 mg/kg/h) or romifidine (30 lg/kg/h) for 2 h. Blood samples were collected from the pulmonary artery before and after loading doses, during the CRI, and for 1 h after discontinuing drugs. Blood glucose, base excess (BE), pH, partial pressure of carbon dioxide (P vCO 2 ), strong ion difference (SID est ) and bicarbonate concentration (½HCO It was concluded that loading doses of alpha 2 -adrenergic agonists followed by CRIs produce [Glu] B , acid-base and electrolyte changes. The clinical significance of the reported changes remains to be investigated and absolute values should be interpreted with caution, as fluid boli were used for cardiac output measurements, but may become important during prolonged infusion and in critically ill patients.

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“…Muir and Gadawski (2002) and Freeman and others (2002) suggested that the decrease in heart rate induced by romifidine is not dose dependent. However, the doses used by those authors, in cats and horses, respectively, were at the high end of the dose range.…”

Section: Discussionmentioning

confidence: 99%

Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats

Belda

Laredo²,

Escobar³

et al. 2008

Veterinary Record

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This study was designed to compare the effects of three doses of romifidine (200, 400 and 600 microg/kg) with medetomidine (80 microg/kg) administered intramuscularly to five cats. The quality of sedation and the cardiovascular and respiratory effects of each treatment were evaluated, and the onset and duration of the sedation, and the cats' recovery times, were measured. Cardiorespiratory variables were also analysed. The dose of 200 microg/kg romifidine was clinically superior to the other doses of romifidine, providing moderate sedation, with minor cardiorespiratory and other adverse effects. However none of the doses of romifidine induced as deep and reliable sedation as the dose of medetomidine.

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Cardiovascular effects of romifidine in the standing horse

Cited by 47 publications

References 12 publications

The Use of Alpha-2 Agonists in the Equine Practice: Comparison between Three Molecules

The Use of Alpha-2 Agonists in the Equine Practice: Comparison between Three Molecules

Blood glucose, acid–base and electrolyte changes during loading doses of alpha2-adrenergic agonists followed by constant rate infusions in horses

Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats

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