The Use of Alpha-2 Agonists in the Equine Practice: Comparison between Three Molecules

The effects of a loading dose followed by constant rate infusion of xylazine compared with romifidine on sedation, ataxia and response to stimuli in horses

“…1a) and therefore might also be attributed to transiently deeper sedation with xylazine. Contrary to our results, previous studies showed that instability and ataxia were significantly less with romifidine compared to other alpha 2adrenergic agonists (England et al 1992;Hamm et al 1995;Nannarone et al 2007). However, it might be possible that during CRI, horses learn to counterbalance the instability making differences between treatments less evident over time in the present study.…”

Evaluation of the clinical efficacy of two partial intravenous anesthetic protocols, compared with isoflurane alone, to maintain general anesthesia in horses

“…Ketamine, combined with guaifenesin, 16 lidocaine, 17 medetomidine, and guaifenesin 18 or medetomidine and benzodiazepines, 19 has been the drug most commonly used for this purpose. 24,25 For this reason, it could represent a useful adjunct to ketamine for PIVA in horses. 22,23 Among α 2 -adrenergic receptor agonists, romifidine provides longer lasting analgesia and less ataxia, compared with equipotent sedative doses of xylazine, detomidine, and romifidine.…”

Análisis del patrón locomotor mediante acelerometría triaxial en caballos sedados con acepromacina

“…En este estudio se puede afirmar que la actividad motora espontánea tanto al paso como al trote, no se ve alterada con acepromacina a 0.04 mg/kg. Las alteraciones en el patrón locomotor son debidas a una depresión del SNC, a diferencia del efecto sedante y miorrelajante descrito para los fármacos agonistas de los receptores α2 (Nannarone et al, 2007).…”