Aim: This research will be performed with the aim of determining the effect of training and telephone counseling given to hypertension patients on drug medication adherence and rational drug use. Methods: The research is planned as a singleblind, randomized, controlled experimental study. The study protocol will be created using the SPIRIT guide and reporting of the research will be constructed according to the CONSORT checklist. The research will be performed from July 2021 to June 2022 with hypertension patients attending in a state hospital. The population of the study will be hypertension patients who applied to the polyclinic, and the sample will be 92 hypertension patients, 46 of which are experimental and 46 control. In the research, patients will be randomly assigned to experiment and control groups with the block randomization method. Research data will be collected with the 'Patient Description Form', 'Drug Medication Adherence Self-Efficacy Scale Short Form' and 'Rational Drug Use Scale'. Hypertension patients in the experiment group will undergo 'Drug Use and Rational Drug Use Training for Hypertension Patients'. Additionally, patients in the experiment group will be given telephone counseling lasting mean 10-15 minutes a total of 4 times; 2 times during the 1st month (2nd and 4th week), 1 time during the 2nd month (8th week) and 1 time during the 3rd month (12th week). Control group patients will receive routine hospital care. Results: This study is the study protocol for a single-blind randomized controlled experimental study. The results will be explained when the study data are collected and analyzed. Conclusion: This protocol will assess the effect of training and telephone counseling given to hypertension patients on their adherence to drug medication and rational drug use.