Cardiovascular Disease and Cancer: Is There Increasing Overlap?

Vincent, Logan; Leedy, Douglas; Masri, Sofia Carolina; Cheng, Richard K.

doi:10.1007/s11912-019-0796-0

Cited by 48 publications

(45 citation statements)

References 143 publications

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“…To the best of our knowledge, there are no studies with a physical exercise intervention that used cardiovascular outcomes as primary endpoint. Some exploratory analyses of the existing studies have shown beneficial outcomes in terms of cardiovascular outcomes, such as preserved cardiorespiratory fitness [ 22 ], lower insulin levels [ 23 ] and less treatment-related tachycardia [ 24 ]. Intervention trials aiming to ameliorate treatment-related cardiovascular toxicity by a physical exercise intervention are ongoing.…”

Section: Discussionmentioning

confidence: 99%

Approaches to management of cardiovascular morbidity in adult cancer patients – cross-sectional survey among cardio-oncology experts

et al. 2020

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Background In cardio-oncology, a range of clinical dilemmas can be identified where high-quality evidence for management is still lacking. The aim of this project was to study clinical practices and expert approaches to several clinical cardio-oncological dilemmas regarding prediction, prevention and treatment of cardiovascular disease in adult cancer patients. Methods A cross-sectional online survey was sent out to internationally renowned experts in the field of cardio-oncology. Participants were selected based on being first or last authors of papers in the field of cardio-oncology, or principal investigators to trials in this field. Results Topics discussed include, among others, the use of biomarkers for subclinical cardiovascular toxicity, approaches towards primary prevention and follow-up with medication and life-style recommendations, and management of fluoropyrimidine-vasospasm, QTc-prolongation and asymptomatic declines in left ventricular ejection fraction. Conclusion The answers provided in this survey have shed light on expert-based practices in cardio-oncologic dilemmas. Attitudes towards, as well as discrepancies in those dilemmas are presented. Existing discrepancies clearly indicate the need for generation of high-quality data that allows for more evidence-based recommendations in the future.

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Section: Discussionmentioning

confidence: 99%

Approaches to management of cardiovascular morbidity in adult cancer patients – cross-sectional survey among cardio-oncology experts

et al. 2020

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“…In Belgium, heart disease and cancer combine to account for 31% and 23% of deaths in women and 27% and 29% of deaths in men [2,3]. Although commonly thought of as two separate disease entities, cardiovascular disease (CVD) and cancer possess various similarities and possible interactions, including a number of similar risk factors (age, obesity, diabetes mellitus), suggesting a shared biology [4,5]. The associated timing of CVD and cancer onset is thus largely influenced by modifiable risk factors.…”

Section: Heart and Cancer: Common Risk Factorsmentioning

confidence: 99%

Cardio-oncology: where do we stand for in Belgium?

2020

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Cardiovascular disease (CVD) and cancer represent the two main causes of death in industrialised countries. Both share common risk factors (diabetes, obesity, hypertension, diet, smoking, etc.). The associated timing of CVD and cancer onset is thus largely influenced by modifiable risk factors. Advances in cancer treatment have extended the lives of patients with cancer, but for some at the cost of adverse cardiovascular events. The rapidly growing number of patients surviving cancer, often in the setting of advanced age, new or pre-existing CV disease and risk factors, the management of these patients has become the concern of experts in cardio-oncology. The goal of cardio-oncology is to provide optimal care for patients with cancer and/or at risk of cardiovascular disease. To date, no specific cardio-oncology teaching programme is available in Belgium. The present paper reports the results of the Belgian Society of Cardiology (BSC) survey on cardio-oncology. The vast majority of respondents (154/159, 97%) are in favour of organising courses or educational meetings on cardio-oncology. A dedicated cardio-oncology clinic was present in only 40% of the hospitals that participated in the survey. Compared to the data collected by the European Society of Cardiology, the number of respondents considering themselves as experts in the management of left ventricular dysfunction or atrial fibrillation complicating cancer treatment was much lower in Belgium (11% vs. 30%).

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“…According to 1582 long-term cancer survivors surveyed in California, 62% were overweight or obese, 55% were hypertensive, 21% were diabetic, 18% were physically inactive, and 5% were current smokers [11]. An analysis of these California cancer registry data highlighted the possible role of shared risk factors in the development of both cancer and cardiovascular disease, reporting that cancer survivors tend to have multiple cardiovascular disease risk factors and that survivorship care often does not address these risk factors [11,12]. Early recognition and treatment of cardiovascular risk factors may be important during survivorship, as this increased risk of cardiovascular death is evident approximately 7 years postdiagnosis [2,5].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Assessment Tool for Breast Cancer Survivors and Oncology Providers: Usability Study

Weaver¹,

Klepin²,

Wells³

et al. 2021

JMIR Cancer

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Background Cardiovascular health is of increasing concern to breast cancer survivors and their health care providers, as many survivors are more likely to die from cardiovascular disease than cancer. Implementing clinical decision support tools to address cardiovascular risk factor awareness in the oncology setting may enhance survivors’ attainment or maintenance of cardiovascular health. Objective We sought to evaluate survivors’ awareness of cardiovascular risk factors and examine the usability of a novel electronic health record enabled cardiovascular health tool from the perspective of both breast cancer survivors and oncology providers. Methods Breast cancer survivors (n=49) recruited from a survivorship clinic interacted with the cardiovascular health tool and completed pre and posttool assessments about cardiovascular health knowledge and perceptions of the tool. Oncologists, physician assistants, and nurse practitioners (n=20) who provide care to survivors also viewed the cardiovascular health tool and completed assessments of perceived usability and acceptability. Results Enrolled breast cancer survivors (84% White race, 4% Hispanic ethnicity) had been diagnosed 10.8 years ago (SD 6.0) with American Joint Committee on Cancer stage 0, I, or II (45/49, 92%). Prior to viewing the tool, 65% of survivors (32/49) reported not knowing their level for one or more cardiovascular health factors (range 0-4). On average, only 45% (range 0%-86%) of survivors’ known cardiovascular health factors were at an ideal level. More than 50% of survivors had ideal smoking status (45/48, 94%) or blood glucose level (29/45, 64%); meanwhile, less than 50% had ideal blood pressure (12/49, 24%), body mass index (12/49, 24%), cholesterol level (17/35, 49%), diet (7/49, 14%), and physical activity (10/49. 20%). More than 90% of survivors thought the tool was easy to understand (46/47, 98%), improved their understanding (43/47, 91%), and was helpful (45/47, 96%); overall, 94% (44/47 survivors) liked the tool. A majority of survivors (44/47, 94%) thought oncologists should discuss cardiovascular health during survivorship care. Most (12/20, 60%) oncology providers (female: 12/20, 60%; physicians: 14/20, 70%) had been practicing for more than 5 years. Most providers agreed the tool provided useful information (18/20, 90%), would help their effectiveness (18/20, 90%), was easy to use (20/20, 100%), and presented information in a useful format (19/20, 95%); and 85% of providers (17/20) reported they would use the tool most or all of the time when providing survivorship care. Conclusions These usability data demonstrate acceptability of a cardiovascular health clinical decision support tool in oncology practices. Oncology providers and breast cancer survivors would likely value the integration of such apps in survivorship care. By increasing awareness and communication regarding cardiovascular health, electronic health record–enabled tools may improve survivorship care delivery for breast cancer and ultimately patient outcomes.

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Cardiovascular Disease and Cancer: Is There Increasing Overlap?

Cited by 48 publications

References 143 publications

Approaches to management of cardiovascular morbidity in adult cancer patients – cross-sectional survey among cardio-oncology experts

Approaches to management of cardiovascular morbidity in adult cancer patients – cross-sectional survey among cardio-oncology experts

Cardio-oncology: where do we stand for in Belgium?

Cardiovascular Assessment Tool for Breast Cancer Survivors and Oncology Providers: Usability Study

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