Cardiovascular Changes in Menopause

Nair, Anil; Pillai, A.; Nair, Nandini

doi:10.2174/1573403x16666201106141811

Cited by 38 publications

(37 citation statements)

References 74 publications

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“…While menopause is associated with changes consistent with cardiovascular aging. 23 In consequence, their ovarian function gradually decreased. 24 That would lower the estrogen which could promote smooth muscle relaxation, dilate blood vessels and potential resistance to oxidative stress damage.…”

Section: Discussionmentioning

confidence: 99%

A cross‐sectional study of the interaction between night shift frequency and age on hypertension prevalence among female nurses

Zhao

et al. 2022

J of Clinical Hypertension

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Night shift is a common work schedule. This study aimed to analyze the interaction between age and frequency of night shift on the hypertension prevalence. A census questionnaire was conducted in 512 medical institutions in 11 cities of Hebei Province. One lakh twenty‐one thousand nine hundred three female nurses were included in this study. Binary Logistic regression analysis was done by SPSS Version 26.0. The youngest age group without night shift was used as the reference group. The odds ratio was calculated by different combinations of interaction items. Interaction coefficients were calculated by an Excel table designed by Andersson. Compared with the 18–25 year old ones without night shift, there existed an additive interaction between the age of 36–45 and more than 5–10 night shifts per month on hypertension prevalence. Odds ratio, the relative excess risk of interaction, the attributable proportion of interaction, and the synergy index and their 95% confidence intervals were 2.923(2.292‐3.727), 0.631(0.309‐0.954), 0.216(0.109‐0.323), 1.488(1.158‐1.913). Additive interaction was also found between the age of 36–45 and more than 10 night shifts per month. OR, RERI, API, SI, and their 95% confidence intervals were 3.430(2.273‐5.175) 1.037(0.061‐2.013), 0.303(0.089‐0.516), and 1.746(1.093‐2.788). There also existed an additive interaction between the age of 46–65 and more than 5–10 night shifts per month on hypertension prevalence. OR, RERI, API, SI, and their 95% confidence intervals were 7.398(5.595‐9.781) 1.809(0.880‐2.739), 0.245(0.148‐0.341), and 1.394(1.199‐1.622).There existed interaction between specific age groups and night shift frequency on the prevalence of hypertension among female nurses.

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Section: Discussionmentioning

confidence: 99%

A cross‐sectional study of the interaction between night shift frequency and age on hypertension prevalence among female nurses

Zhao

et al. 2022

J of Clinical Hypertension

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“…Estrogen binding to its receptor can regulate glucose and lipid metabolism in a variety of ways. Disturbances in these metabolic pathways would contribute to the development of metabolic syndrome in postmenopausal women, as well as an increased risk of cardiovascular disease (38,39). In estrogen-de cient rats, MPS can be alleviated by maintaining gut microbial diversity (40).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Menopausal Syndrome and Gut Microbes

Liu

Zhou²,

Huang³

et al. 2022

Preprint

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Purpose The association between gut microbes dysbiosis and menopause syndrome (MPS) is poorly understood. The aim of this study was to explore the relationship between MPS and gut microbes. Methods 77 MPS patients (P group) and 24 menopausal healthy women (H group) were recruited in this study. Participants were collected their stool specimen and clinical parameters (including demographic data, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), et al ). We looked at the differences in gut microbiota between two groups by 16S ribosomal RNA gene sequencing. LEfSe was used to identify bacteria with varying abundances in different groups. Clinical parameters and microbial species Spearman correlation coefficients were calculated. PICRUSt was used to predict the potential KEGG Ortholog functional profiles of microbial communities. Results The abundance of 14 species differed substantially between the MPS and menopausal healthy women (LDA significance threshold > 2.0) according to LEfSe analysis. Using Spearman's correlation analysis, it was discovered that Aggregatibacter segnis, Bifidobacterium animalis, Acinetobacter guillouiae were enriched in menopausal healthy women, with a positive correlation with the E2 and a negative correlation with the FSH and LH (p ༜ 0.05); the abundances of species had a close correlation with the other clinical parameters, including the KI score, hot flash, et al. KEGG L3 metabolic pathways relevant to cardiovascular disease and carbohydrate metabolism were also enriched in the MPS (p ༜ 0.05), according to functional prediction by PICRUST and analyzed by Dunn test. Conclusion There were gut microbes dysbiosis in MPS, which is reflected in the deficiency of the abundance of Aggregatibacter segnis, Bifidobacterium animalis and Acinetobacter guillouiae related to the level of sex hormones. In MPS individuals, species with altered abundances and unique functional pathways were found.

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“…У пацієнток з ожирінням спостерігається підвищений рівень маркерів запалення -IL-6 та С-реактивного білка (С-РБ) [8]. Прозапальні цитокіни: TNF-α, IL-6 та IL-1β справляють паракринний ефект, що зумовлює інсулінорезистентність.…”

Section: г і н е к о л о г і яunclassified

Possibilities of using xylitol and L-arginine drugs in menopause management

Лахно

2021

RHW

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Menopause is accompanied by the development of a complex of disorders leading to the onset of metabolic syndrome X. In the pathogenesis of these disorders, hypoestrogenemia and hyperandrogenaemia play a significant role, which cause obesity, dyslipidemia, and type 2 diabetes mellitus. Adipose tissue is a «field» for the synthesis of mediators of chronic inflammation and oxidative stress. Unfortunately, hormone replacement therapy is not recognized as an intervention for preventing metabolic disorders. Since metabolic disorders reduce the duration of the period of working capacity and life in general, it is necessary to develop a management program focused on preventing or reducing their negative impact on the woman’s well-being. Xylitol is known as an energy-balancing agent with excellent anticatabolic effects. Recently, it was found that xylitol levels can be used to predict the prospects for weight loss without surgery in morbid obesity patients. The normalization of endothelial function is one of the key tasks in the management of menopausal women. It has been proven that a decrease in the level of nitric oxide in women of transitional age causes the development of vasculopathy. Since L-arginine is a substrate for the synthesis of nitric oxide, the use of its preparations is a promising option for women receiving hormone replacement therapy. The development of a therapeutic and prophylactic strategy using hormone replacement therapy, well-balanced physical activity, diet therapy and the use of xylitol and L-arginine preparations can become a reserve for improving the quality of life of women aged over 45. Possible criteria for assessment the effectiveness of a treatment program designed for six months are blood pressure, body mass index, blood glucose, HOMA index, lipid profile, micronutritients levels, as well as an assessment on the Kuperman scale.

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Cardiovascular Changes in Menopause

Cited by 38 publications

References 74 publications

A cross‐sectional study of the interaction between night shift frequency and age on hypertension prevalence among female nurses

A cross‐sectional study of the interaction between night shift frequency and age on hypertension prevalence among female nurses

The Relationship Between Menopausal Syndrome and Gut Microbes

Possibilities of using xylitol and L-arginine drugs in menopause management

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