Cardiovascular autonomic control in myotonic dystrophy type 1: a correlative study with clinical and genetic data

Leo, Rita Di; Rodolico, Carmelo; Gregorio, Cesare de; Recupero, Antonino; Coglitore, Sebastiano; Annesi, Grazia; Toscano, Antonio; Messina, C; Vita, Giuseppe

doi:10.1016/j.nmd.2003.11.002

Cited by 25 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, comparison between this study and the results obtained by these authors is not appropriate. In a study similar to ours, Di Leo et al 17 , investigated HRV in MD type 1 patients using the autoregressive method with different body positions. In 23 MD patients and a control group, they observed a significant decrease in LFms 2 , a marker of sympathetic activity, for MD patients in the supine position.…”

Section: Gender Influence Influência Do Gêneromentioning

confidence: 90%

“…In contrast to other research [14][15][16][17][18] , this study assesses HRV during short time periods in sitting and supine positions, in addition to analyzing the magnitude of gender differences. Methodological procedures were based on the fact that [24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

“…A number of investigations on the overall function of the autonomic nervous system in patients with MD show that the presence of autonomic neuropathy is highly unlikely 1,12,13 . However, studies on autonomic modulation of HR in patients with MD have obtained conflicting results [14][15][16][17][18] . The present study aimed to evaluate the possible differences in autonomic modulation of HR between the sexes for patients with MD and healthy individuals in different body positions and the influence of interaction between sex and disease on autonomic modulation of HR in different body positions.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1

Fregonezi

Araújo

Dourado

et al. 2012

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

and in the sinoatrial node associated to myocyte hypertrophy 7 . Patients with greater skeletal muscle impairment are older and experience heart problems more frequently 8 .The autonomic nervous system plays a crucial role in heart rate (HR) modulation. A decrease in its variability is a predictor of morbidity and mortality 9,10 . Earlier research found that healthy women showed greater vagal dominance over HR, which seems to account for their enhanced cardioprotection compared to men, although these differences decrease with age 11. The study of heart rate variability (HRV) has therefore been proposed as a simple, inexpensive and non-invasive method that provides information on neurocardial integrity. A number of investigations on the overall function of the autonomic nervous system in patients with MD show that the presence of autonomic neuropathy is highly unlikely 1,12,13 . However, studies on autonomic modulation of HR in patients with MD have obtained conflicting results [14][15][16][17][18] . The present study aimed to evaluate the possible differences in autonomic modulation of HR between the sexes for patients with MD and healthy individuals in different body positions and the influence of interaction between sex and disease on autonomic modulation of HR in different body positions. IntroductionMyotonic dystrophy (MD) is the most frequent form of muscular dystrophy in adults 1,2 . Clinical manifestations of MD are myotony, muscle weakness, cardiac abnormalities, cataracts, endocrine and digestive tract disturbances; sleep disorders and baldness 3-5 . Heart problems experienced by patients with MD are well known 1,6 . Most patients are asymptomatic; however, alterations in cardiac physiology are common, as observed in electrocardiograms 6 . Clinical manifestations include conduction delay, rhythm disturbances and myocardial disease. Electrocardiographic disorder indicates abnormalities in intraventricular and atrioventricular conduction, atrial fibrillation and ventricular arrhythmias. Histopathology data show fibrosis in the conduction system Abstract Background: Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and reliable technique that can be useful for studying the influence of the autonomic nervous system on the heart.

show abstract

Section: Gender Influence Influência Do Gêneromentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1

Fregonezi

Araújo

Dourado

et al. 2012

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…In single cases LVHT has been detected [25]. Occasionally, the autonomic nervous system is involved and made responsible for sudden cardiac death in some patients [26]. Concerning the correlation between the CTG-repeat size and CI there are conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Cardiac involvement over 10 years in myotonic and Becker muscular dystrophy and mitochondrial disorder

Finsterer

Stöllberger

Blazek

et al. 2007

International Journal of Cardiology

View full text Add to dashboard Cite

“…Recently, using both time domain and frequency domain techniques, we have demonstrated that a mixed, especially parasympathetic, cardiovascular autonomic dysfunction may occur in another multisystemic disease such as myotonic dystrophy type 1 (DM1), also being not related to the cardiac involvement [3].…”

Section: Discussionmentioning

confidence: 99%

Evidence of cardiovascular autonomic impairment in mitochondrial disorders

et al. 2007

View full text Add to dashboard Cite

show abstract

Cardiovascular autonomic control in myotonic dystrophy type 1: a correlative study with clinical and genetic data

Cited by 25 publications

References 23 publications

Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1

Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1

Cardiac involvement over 10 years in myotonic and Becker muscular dystrophy and mitochondrial disorder

Evidence of cardiovascular autonomic impairment in mitochondrial disorders

Contact Info

Product

Resources

About