Cardiovascular and metabolic risk assessment in patients with lichen planus: A tertiary care hospital-based study from Northern India

Mushtaq, Sabha; Dogra, Devraj; Dogra, Naina; Shapiro, Jonathan S.; Fatema, Kaniz; Faizi, Nafis; Gupta, Gunjan

doi:10.4103/idoj.idoj_228_19

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…22 Although it is said that there is no sexual predilection in LP, however in our study revealed that most of the patients with oral lichen planus in type 2 diabetic groups were male. 23 In one study, 26(52%) of the cases were male and 24(48%) were female with a slight male preponderance with a male: female ratio of 1.08:1, similar to a study done by Mushtaq et al 23,24 In contrast, multiple studies support higher proportion of men than women among the population. 2,18 In a recent study held at Sialkot, they found 18 patients out of 500 diagnosed cases of Diabetes Mellitus with Oral Lichen Planus reporting prevalence of 3.6% with male to female ratio of 1:1.9.…”

Section: Discussionsupporting

confidence: 63%

Frequency of Oral Lesions in Diabetic Patients on Oral Hypoglycemic Drugs and Insulin

Ahmed¹,

Shah²,

Sohail³

et al. 2023

PJMHS

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Background: Lichen planus is a pre-cancerous condition which is immune mediated. It is often linked with other autoimmune diseases such as Diabetes Mellitus. It is linked with both Type 1 and Type 2 DM. Methods: A retrospective cross-sectional study that was conducted at Jinnah Sindh Medical University on data of patients coming to Oral Medicine OPD from January 2020- December 2022. Diabetic patient`s data was extracted, and secondary analysis was done on it to find out the frequency of the lesions in both types. Results: Data of 211 patients were analyzed through SPSS ver. 20. Total of 30 patient with oral lesions presented with diabetes mellitus with 8 having hepatitis c. Data was excluded of those with co-morbid. The predominant age group was 41-50 years, all males, presenting with type 2 DM. Gingivitis(N=10) was the commonest followed by Oral Lichen Planus(N=7), Periodontitis(N=3), and Infections(N=2).The lesions were predominant in patients on Glucophage and insulin. Conclusion: Diabetes Mellitus predisposes patients to a variety of oral problems. Early diagnosis of these lesions and changes in medication as per requirement to treat these lesions may benefit the quality of life of these patients. Keywords: Oral Lichen Planus, Diabetes Mellitus, Autoimmune disorder

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Section: Discussionsupporting

confidence: 63%

Frequency of Oral Lesions in Diabetic Patients on Oral Hypoglycemic Drugs and Insulin

Ahmed¹,

Shah²,

Sohail³

et al. 2023

PJMHS

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“…1 Several mechanisms have been postulated for the development of vitiligo, including T cell-mediated inflammation, oxidative stress impairment and generation of proinflammatory cytokines, which may be associated with the risk of major adverse cardiovascular events (MACE). 2,3 Studies have explored the relationship between MACE and other skin inflammatory conditions such as psoriasis, atopic dermatitis and alopecia areata, [4][5][6] but the association between vitiligo and MACE remains obscure. Therefore, we conducted this population-based cohort study to investigate this issue.…”

Section: Lack Of Association Between Vitiligo and Major Adverse Cardi...mentioning

confidence: 99%

Lack of association between vitiligo and major adverse cardiovascular events: A population‐based cohort study

Pan

et al. 2023

Acad Dermatol Venereol

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“…Elevated homocysteine levels were observed in individuals with LP, and this could potentially serve as an indicator for predicting CVD. Moreover, the polymorphism of the methylenetetrahydrofolate reductase gene might act as a potential risk factor for LP development, making these patients more susceptible to an increased risk of CVD [127][128][129].…”

Section: Lichen Planus (Lp)mentioning

confidence: 99%

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Maranduca,

Cosovanu,

Clim

et al. 2023

Diagnostics

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Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more.

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Cardiovascular and metabolic risk assessment in patients with lichen planus: A tertiary care hospital-based study from Northern India

Cited by 8 publications

References 26 publications

Frequency of Oral Lesions in Diabetic Patients on Oral Hypoglycemic Drugs and Insulin

Frequency of Oral Lesions in Diabetic Patients on Oral Hypoglycemic Drugs and Insulin

Lack of association between vitiligo and major adverse cardiovascular events: A population‐based cohort study

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

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