Cardiovascular and metabolic influences of fetal smoke exposure

Bakker, Hanneke; Jaddoe, Vincent W. V.

doi:10.1007/s10654-011-9621-2

Cited by 72 publications

(62 citation statements)

References 118 publications

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“…(3) The prevalence of obesity in children of mothers who smoked during pregnancy has also been reported. (3,30) In the present study, the mean smoking history was higher among older smokers than among younger smokers, which is most probably related to longer tobacco use among older individuals and, therefore, to a longer smoking history. A study conducted in Brazil showed similar results among men, and the frequency of heavy smoking (> 20 cigarettes/day) was twice as high in those aged 18-24 years and in those aged 55-64 years, declining thereafter.…”

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confidence: 44%

Tabagismo e obesidade abdominal em doadores de sangue

et al. 2012

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Objective: To assess the association between smoking and abdominal fat among male blood donors. Methods: This was a cross-sectional study involving 1,235 adult male blood donors (age, 20-59 years) in the city of Cuiabá, Brazil. Socioeconomic, demographic, and anthropometric data, as well as information on the lifestyle of the participants, were collected. In this study, waist circumference and waist-to-hip ratio were used as markers of abdominal fat. The association between these two markers and smoking was analyzed by multiple linear regression in separate models, adjusted for potential confounders. Results: Of the 1,235 respondents, 273 (22.1%) reported being smokers, and, of those, 99 (36.3%) reported smoking more than 15 cigarettes per day. The average body mass index was lower among smokers than among nonsmokers (p < 0.001). In the multiple linear regression analyses, smoking was associated with waist circumference and waist-to-hip ratio for smokers of 6-10 cigarettes/day and of ≥ 11 cigarettes/day. Conclusions: In our sample, smoking was positively associated with indicators of abdominal fat, regardless of potential confounding factors, including the consumption of alcoholic beverages. Keywords:Smoking; Obesity; Abdominal fat. ResumoObjetivo: Analisar a associação entre tabagismo e obesidade abdominal em doadores de sangue. Métodos: Estudo de corte transversal com 1.235 homens adultos doadores de sangue (idade: 20-59 anos) em Cuiabá, MT. Foram coletados dados socioeconômicos, demográficos e antropométricos, bem como informações sobre o estilo de vida dos participantes. Neste estudo, a circunferência da cintura e a relação cintura/quadril foram utilizadas como marcadores de obesidade abdominal. A associação desses dois marcadores com tabagismo foi analisada por meio da regressão linear múltipla em modelos distintos, ajustados para potenciais fatores de confusão. Resultados: Dos 1.235 entrevistados, 273 (22,1%) declararam ser fumantes e, desses, 99 (36,3%) relataram fumar mais de 15 cigarros por dia. A média do índice de massa corpórea nos fumantes foi menor que nos não fumantes (p < 0,001). Nas análises de regressão linear múltipla, o tabagismo mostrou-se associado à circunferência da cintura e à relação cintura/quadril em fumantes de 6-10 cigarros/dia e de ≥ 11 cigarros/dia. Conclusões: Nesta amostra, o tabagismo associou-se positivamente com os indicadores da obesidade abdominal, independentemente de potenciais fatores de confusão, inclusive o consumo de bebidas alcoólicas.

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Tabagismo e obesidade abdominal em doadores de sangue

et al. 2012

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“…Clearly there is a great deal of interest in cigarette smoking and use of other tobacco and nicotine delivery products in pregnant smokers due to the substantial adverse short- and longer-term impacts on the developing fetus (Bakker & Jaddoe, 2011; Cnattingius, 2004; Dietz et al, 2010). There are also well-substantiated differences in the smoking of pregnant women compared to the general population that warrant caution against assuming that observations regarding the effects of tobacco and nicotine in one group can be readily generalized to the other.…”

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confidence: 99%

Comparison of nicotine dependence indicators in predicting quitting among pregnant smokers.

Kurti¹,

Davis²,

Skelly³

et al. 2016

Experimental and Clinical Psychopharmacology

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Research in the general population of smokers indicates that across various measures of nicotine dependence, time to first cigarette (TTFC) is the strongest single-item predictor of quitting success. Whether those findings generalize to pregnant smokers is unclear. To investigate this matter, we compared TTFC to cigarettes per day (CPD) and the Heaviness of Smoking Index (HSI) in predicting late-pregnancy abstinence among 289 pregnant women enrolled in four smoking-cessation trials assessing the efficacy of financial incentives. Logistic regression was used to compare predictors with model fit measured using the c statistic (range = 0.5 [poor prediction] to 1.0 [perfect prediction]). In simple regressions, model fit was comparable across the three measures although strongest for CPD alone (c = 0.70, 0.68, 0.66 for CPD, HSI, and TTFC, respectively). In a stepwise multiple regression, treatment entered first (c = 0.67), then CPD (c = 0.77), quit attempts pre-pregnancy (c = .81), TTFC (c = .82), and quit attempts during pregnancy (c = .83). We saw no evidence supporting TTFC as the optimal predictor of quitting among pregnant smokers. Instead, the evidence supported using CPD and TTFC together or CPD alone if using only a single predictor.

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“…cadmium and other toxic factors that have direct adverse effects and might affect placental function and the fetal supply line (8). Maternal smoking leads to restricted blood flow in the vascular beds of specific fetal organs (8).…”

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confidence: 99%

“…Maternal smoking leads to restricted blood flow in the vascular beds of specific fetal organs (8). Animal studies demonstrated adverse effects of high maternal nicotine levels on metabolic development (9).…”

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confidence: 99%

Fetal Exposure to Parental Smoking and the Risk of Type 2 Diabetes in Adult Women

et al. 2014

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OBJECTIVEWe evaluated the associations of both maternal and paternal smoking during pregnancy with the risk of type 2 diabetes in daughters and explored whether any association was explained by weight at birth or BMI throughout life. RESEARCH DESIGN AND METHODSWe used data from 34,453 participants of the Nurses' Health Study II. We used Cox proportional hazards models to examine the associations of maternal and paternal smoking during pregnancy with incidence of type 2 diabetes in daughters between 1989 and 2009. RESULTSMaternal smoking during the first trimester only was associated with the risk of type 2 diabetes in the offspring, independent of confounders, birth weight, and later-life BMI (fully adjusted hazard ratio 1.34 [95% CI 1.01, 1.76]). In the ageadjusted models, both continued maternal smoking during pregnancy and paternal smoking tended to be associated with an increased risk of type 2 diabetes in daughters. Perinatal and adult life variables did not explain these associations, but additional adjustment for current BMI fully attenuated the effect estimates. CONCLUSIONSThe associations of maternal and paternal smoking during pregnancy with the risk of type 2 diabetes in daughters were largely explained by BMI throughout the life course. Further studies are needed to explore the role of first-trimester-only maternal smoking on insulin resistance in the offspring. Also, similar effect estimates for maternal and paternal smoking suggest that the associations reflect shared family-based or lifestyle-related factors.

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Cardiovascular and metabolic influences of fetal smoke exposure

Cited by 72 publications

References 118 publications

Tabagismo e obesidade abdominal em doadores de sangue

Tabagismo e obesidade abdominal em doadores de sangue

Comparison of nicotine dependence indicators in predicting quitting among pregnant smokers.

Fetal Exposure to Parental Smoking and the Risk of Type 2 Diabetes in Adult Women

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