Cardiovascular and hematological parameters affected by feeding various polychlorinated biphenyls to the single comb white leghorn cockerel

Iturri, Sergio J.; Cogger, E. A.; Ringer, Robert K.

doi:10.1007/bf01975467

Cited by 4 publications

(3 citation statements)

References 17 publications

(18 reference statements)

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“…Lillie et al (1974b) reported that feeding 10 and 20 ppm of Aroclor 1248 to mature White Leghorn males had no effect on reproductive performance although liver weight was increased. Other workers have noted a marked decrease in comb size of cockerels fed Aroclor 1242 or 1254 (Iturri et al 1974, Platonow and Funnell 1971, Rehfeld et al, 1971. The decreased size of androgenic-dependent organs may indicate increased metabolism of androgens by hepatic enzymes.…”

Section: Discussionmentioning

confidence: 93%

Liver mixed function oxidases in chickens: Induction by polychlorinated biphenyls and lack of induction by DDT

Cecil

Harris

Bitman

1978

Arch. Environ. Contam. Toxicol.

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Microsomal hydroxylase and demethylase activities were compared in livers from White Leghorn cockerels fed polychlorinated biphenyls (PCBs) containing 21 to 68% chlorine, or p,p'-DDT. The higher chlorinated PCBs, Aroclor 1254 and 1268, were potent inducers of hepatic enzyme activity while DDT did not induce these enzymes. Aroclor 1254 was the most potent inducer because feeding 5 ppm increased liver aminopyrine demethylase activity 1.5X but did not affect liver weight. Feeding 50 and 500 ppm of Aroclor 1254 and 1268 increased liver weight and demethylase activity per mg of protein. A differential response in the two enzymes occurred. Only 500 ppm of Aroclor 1268 increased hydroxylase activity. Aroclor 1242 had no effect on liver enzyme concentration but 50 and 500 ppm of Aroclor 1242 increased liver weights and consequently increased total enzyme activity. Our data demonstrated that in the avian species DDT and PCB did not have the same effect on hepatic microsomal enzyme activity.

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Section: Discussionmentioning

confidence: 93%

Liver mixed function oxidases in chickens: Induction by polychlorinated biphenyls and lack of induction by DDT

Cecil

Harris

Bitman

1978

Arch. Environ. Contam. Toxicol.

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“…Aroclor 1254 2 . Contamination of the feed followed the procedure of Iturri et al (1974). After the hens had been fed the contaminated ration ad libitum for 3 weeks, they were slaughtered, picked, eviscerated, and chilled overnight in ice.…”

Section: Methodsmentioning

confidence: 99%

Polychlorinated Biphenyl Levels in Raw and Cooked Chicken and Chicken Broth

Zabik

1974

Poultry Science

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Drumsticks, breast pieces, thigh meat, thigh skin, and abdominal adipose tissues from hens fed Aroclor 1254 were stewed and pressure cooked. Both cooking methods resulted in similar reductions of polychlorinated biphenyls (PCB's). Cooked chicken pieces had significantly lower PCB's than did raw pieces. Rendering of PCB's with the fat appears to be the major mode of removal.Percentage recoveries calculated from the levels of 1254 found in the cooked meat and broth, as compared to that in the raw pieces varied from 60% for breast pieces to 95% for drumsticks. Except for adipose tissues which had most of the recovered PCB's in the broth, recovered PCB's were about equally divided between the cooked sample and the broth.

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“…Bradycardia has been reported for several species following chlorinated hydrocarbon exposure (9)(10)(11)(12). The mode of action may be attributed to increased vagal tone but remains to be answered.…”

Section: Effect On Cardiovascular Systemmentioning

confidence: 99%

PBB fed to immature chickens: its effect on organ weights and function and on the cardiovascular system.

Ringer¹

1978

Environ Health Perspect

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In a series of polybrominated biphenyl (PBB) feeding trials in White Leghorn cockerel chicks, the effects of PBB on various physiological parameters and organ weights were determined. These measurements included: growth, thyroid function, ECG, cardiac output, blood pressure, hematocrit, erythropoietin levels, and spleen, bursa of Fabricius, thyroid, testes, comb, liver weights. In addition, tissues were histologically examined. PBB, in the commercial grade form of hexabromobiphenyl, was administered continuously in the diet at levels ranging from 50 to 250 ppm. Pair-feeding studies were conducted to ascertain the effects of the drug per se since preliminary trials indicated that PBB administration resulted in decreased feed intake.Chronic administration resulted in depressed body weight as a result of decreased feed intake; decreased comb, testes, spleen, and bursa weights; increased liver and thyroid weight; hydropericardium and ascites; decreased hematological values due to depressed plasma erythropoietin levels; decreased heart rate, packed celi volume, hemoglobin and cardiac output; decreased voltage amplitude of the ECG and a shift in the mean electrical axis. No significant differences were found in blood pressure (mean arterial and pulse pressure), stroke volume, or respiratory rate.

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Cardiovascular and hematological parameters affected by feeding various polychlorinated biphenyls to the single comb white leghorn cockerel

Cited by 4 publications

References 17 publications

Liver mixed function oxidases in chickens: Induction by polychlorinated biphenyls and lack of induction by DDT

Liver mixed function oxidases in chickens: Induction by polychlorinated biphenyls and lack of induction by DDT

Polychlorinated Biphenyl Levels in Raw and Cooked Chicken and Chicken Broth

PBB fed to immature chickens: its effect on organ weights and function and on the cardiovascular system.

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