Cardiovascular and Catecholamine Changes After Administration of Pancuronium in Distressed Neonates

Abstract

Heart rate, blood pressure, transcutaneous gases, and catecholamine changes following intravenous injection of pancuronium were evaluated in seven ill newborn infants (birth weight: 1,280 to 4,500 g; gestational age, 29 to 42 weeks). Each infant was monitored continuously for 30 minutes before and 50 minutes after infusion of the paralyzing agent. There were no significant changes in transcutaneous gases, whereas significant increases in heart rate; systolic, diastolic, and mean blood pressures; and blood norepinephrine and epinephrine levels were found. The increase in heart rate lasted for 30 minutes, and the increase in blood pressure persisted for 50 minutes after administration of the drug. Because of the potential relationship between increased blood pressure and intraventricular hemorrhage and myocardial dysfunction, heart rate and blood pressure must be monitored during infusion of pancuronium in distressed newborns. These data suggest that pancuronium stimulates sympathetic activity in distressed newborns.

Renal effects of general anesthesia from old to recent studies

“…It has vasodilation effects on renal vessels at specific concentrations by releasing prostaglandins, unlike vecuronium, thereby it is thought to play a role in increasing cardiac output as a response to its renal effects (Sai, Ayajiki, Okamura, Nosaka, & Toda, 1998). It is also found to have a direct effect on heart rate, blood pressure, and release of catecholamines (Cabal et al, 1985).…”