Cardiovascular Action of Nuatigenosido fromSolanum sisymbriifolium.

Abstract

The root of Solanum sisymbriifolium Lam (Solanceae), a perennial herb, has been used as a traditional medicine possessing diuretic and antihypertensive properties in Paraguay. It was reported that extracts from this plant exerted hypotensive effects in rats. Nuatigenosido was isolated from the extract as one of the prospective active compounds. We have investigated its pharmacological actions. The current study demonstrated the following results: (1) Nuatigenosido at 100 mg=kg and 1 mg=kg i.v. lowered blood pressure in rats, (2) nuatigenosido at 10 À6 and 10 À5 M augmented the contractile force in the right atrium of a bullfrog, and (3) nuatigenosido at 10 À7 M increased the overshoot amplitude in frog atrial myocytes, action potential durations were shortened, the calcium current (I Ca ) was increased, and the delayed outward potassium current was increased. From these results, it is suggested that nuatigenosido may play an important role in the therapeutic effects of this herb.

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

“…Solanum saponins were reported to have various bioactivies, e.g. cytotoxic [ 257 ], anticancer [ 316 , 317 , 392 ], hepatoprotective [ 242 , 247 ], antihypertensive [ 289 , 291 ], antimelanogenesis [ 211 ], antifungal [ 113 , 114 , 117 ], anti-inflammatory [ 331 , 392 , 448 ] anticonvulsant [ 305 ] and antiviral [ 257 ].…”

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“…The wide variety of the traditional uses of the plant may be due to the presence of these phytochemicals. Pharmacological studies have demonstrated that S. sisymbriifolium known to possess antinociceptive 9 , antihypertensive 12 , cardiovascular 13 , molluscicidal 14 , cytotoxic 15 , sedative and anticonvulsant 11 activities.…”

Characterization of P450 FcpC, the Enzyme Responsible for Bioconversion of Diosgenone to Isonuatigenone in Streptomyces virginiae IBL-14

“…In conclusion, compared to the traditional isolation strategy (9,13,22), our whole-cell system using FcpC from S. virginiae IBL-14 expressed in E. coli can be a potentially valuable method for producing rare nuatigenin-type steroids. Our future work will focus on improving the present fcpC biotransformation system by using different hosts, promoters, vectors, and cloned redox partners for the extensive utilization of novel derivatives of steroidal drugs.…”

“…These compounds have been shown to have potential anticancer effects, antagonistic effects on rheumatoid arthritis, beneficial cardiovascular activities, and antimalarial activities. Examples include ophiofurospiside in Ophiopogon japonicus (28), nuatigenosido in Solanum sisymbriifolium (13), avenacoside in oat (20), and glycosides in Paris polyphylla SM (7). Since the majority of these nuatigenin-type steroids are very rare, strategies for their isolation can lead to very high production costs.…”

“…Nuatigenin-type steroids, such as nuatigenin and isonuatigenin (9,13,22), are rare natural steroidal sapogenins that are important pharmacological compounds. They are found in several healthy foods and traditional medicinal herbs.…”