Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth

The antiproliferative effects of ouabain and everolimus on adrenocortical tumor cells

“…The DNA cell cycle distribution was altered by ouabain only in SW13 cells, while combination treatment revealed no substantial change in both cell lines. In agreement with our data on ouabain, a previous study analyzed 2 different human hepatocellular cell lines for cell cycle distribution at 24h, after treatment with ouabain at 100 and 500 nM [20].…”

Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum

“…The monoglycosidic cardenolide ouabain and the bufadienolide cinobufagin significantly inhibited cell proliferation by attenuating the phosphorylation of extracellular regulated kinase (ERK) and down-regulating the expression of C-myc. These cardiotonic steroids also induced cell apoptosis by increasing the concentration of intracellular free calcium and induced S phase cell cycle arrest by down-regulating the expression of Cyclin A, cyclin dependent kinase 2 (CDK2) and proliferating cell nuclear antigen (PCNA) as well as up-regulating the expression of cyclin dependent kinase inhibitor 1A (p21(CIP1)) (Xu et al, 2011). In our present study we investigated the anticancer activity of cardiac glycosides isolated from Streptocaulon tomentosum Wight & Arn.…”

Inhibition of cell migration by ouabain in the A549 human lung cancer cell line

“…Previous epidemiological studies have implied that cardiac glycosides are capable of inhibiting the growth of cancer cells and decreasing the incidence of certain types of tumors, including leukemia, lymphoma, kidney tumors and urinary tumors. Tumor metastasis is one of the main features of malignant cancer and is the main cause of mortality in cancer patients (6,7). …”