Cardiorespiratory Fitness Suppresses Age‐Related Arterial Stiffening in Healthy Adults: A 2‐Year Longitudinal Observational Study

Gando, Yuko; Murakami, Haruka; Kawakami, Ryoko; Yamamoto, Keizô; Kawano, Hiroshi; Tanaka, Noriko; Sawada, Susumu S.; Miyatake, Nobuyuki; Miyachi, Motohiko

doi:10.1111/jch.12753

Cited by 29 publications

(29 citation statements)

References 45 publications

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“…Here, we determined the relationship between flexibility and the 5-year change in cfPWV. It is well-known that cardiorespiratory fitness is inversely related to arterial stiffness (Vaitkevicius et al, 1993; Gando et al, 2016). Similar to previous findings, the present study also confirmed that arterial stiffness was significantly related to cardiorespiratory fitness.…”

Section: Discussionmentioning

confidence: 99%

“…We measured carotid and femoral PWV (cfPWV) as indicators of aortic stiffness and blood pressure with a vascular test device (form PWV/ABI; Omron Colin, Japan) as described previously (Gando et al, 2016). Waveforms were measured by applanation tonometry according to a standardized protocol.…”

Section: Methodsmentioning

confidence: 99%

“…We measured peak oxygen uptake as an indicator of cardiorespiratory fitness, which was measured according to the protocol of a graded exercise load using a cycle ergometer (Ergomedic 828E Test Cycle, Monark, Sweden, or Excalibur V2.0, The Netherlands), as described previously (Gando et al, 2016). …”

Section: Methodsmentioning

confidence: 99%

“…Having a high level of physical fitness, especially higher cardiorespiratory fitness, is associated with the suppression of age-related arterial stiffening (Vaitkevicius et al, 1993; Gando et al, 2016). Recently, we and others have reported that flexibility, a component of physical fitness (Cureton, 1941), is also negatively associated with arterial stiffening independent of cardiorespiratory fitness in cross-sectional studies (Yamamoto et al, 2009; Nishiwaki et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Greater Progression of Age-Related Aortic Stiffening in Adults with Poor Trunk Flexibility: A 5-Year Longitudinal Study

et al. 2017

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Purpose: Having a low level of physical fitness, especially cardiorespiratory fitness, appears to accelerate age-related aortic stiffening. Whereas, some studies have reported that trunk flexibility is a component of physical fitness, it is also negatively associated with arterial stiffening independent of cardiorespiratory fitness in cross-sectional studies. However, no long-term longitudinal study has determined whether poor trunk flexibility accelerates the progression of age-related aortic stiffening. We examined trunk flexibility and aortic stiffness progression in a 5-year longitudinal study.Methods and Results: A total of 305 apparently healthy men and women participated in this study (49.6 ± 9.5 years of age). Trunk flexibility was measured using a sit-and-reach test. Aortic stiffness was assessed using carotid-femoral pulse wave velocity (cfPWV) at baseline and after 5 years. Analysis of covariance (ANCOVA) was used to assess the association of the annual rate of cfPWV across flexibility levels (low, middle, high). There were no significant differences in baseline cfPWV among the three groups (835 ± 164, 853 ± 140, 855 ± 2.68 cm/s; P = 0.577). Annual ΔcfPWV was significantly higher in the low-flexibility group than in the high-flexibility group (P = 0.009). ANCOVA revealed an inverse relationship between flexibility level and annual ΔcfPWV (14.41 ± 2.73, 9.79 ± 2.59, 2.62 ± 2.68 cm/s/year; P for trend = 0.011). Multiple regression analysis revealed that baseline sit and reach (β = −0.12, −0.70 to −0.01) was independently correlated with ΔcfPWV following adjustment for baseline peak oxygen uptake, age, sex, body fat, heart rate, and cfPWV. The 5-year change in cfPWV was not significantly correlated with 5-year change in sit-and-reach performance (P = 0.859).Conclusion: Poor trunk flexibility is associated with greater progression of age-related aortic stiffening in healthy adults. However, we failed to confirm a significant association between 5-year change in aortic stiffness and 5-year change in trunk flexibility. The association between increased age-related increase in aortic stiffness and deterioration in flexibility due to age may require observation for more than 5 years.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Greater Progression of Age-Related Aortic Stiffening in Adults with Poor Trunk Flexibility: A 5-Year Longitudinal Study

et al. 2017

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“…Gando et al described these findings using a longitudinal design in the general population, observing that the increase in PWV over a 2‐year follow‐up was lower in those participants with higher VO 2max. Our results extend these findings to women with SLE and open an interesting research line highlighting a potential role for CRF to attenuate the well‐known negative consequences of age on vascular health that need to be contrasted in future studies.…”

Section: Discussionmentioning

confidence: 99%