Cardiorespiratory fitness and age‐related arterial stiffness in women with systemic lupus erythematosus

Montalbán-Méndez, Cristina; Soriano‐Maldonado, Alberto; Vargas‐Hitos, José Antonio; Sáez-Urán, Luis Manuel; Rosales-Castillo, Antonio; Morillas-de-Laguno, Pablo; Gavilán‐Carrera, Blanca; Jiménez-Alonso, J

doi:10.1111/eci.12885

Cited by 21 publications

(16 citation statements)

References 43 publications

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“…This increase in fitness is clinically relevant since a 1-MET increase is associated with a 13% to 15% reduction in CV and all-cause mortality [51], and with 10% to 30% lower adverse cardiovascular event rates [25]. Moreover, higher cardiorespiratory fitness has been shown to be related to a lower CV risk in patients with rheumatoid arthritis [52] and with lower age-related arterial stiffness in SLE [20], indicating that future studies should address the impact of long-term changes in cardiorespiratory fitness on CV health in SLE and other rheumatic populations.…”

Section: Discussionmentioning

confidence: 99%

“…The American College of Sports Medicine (ACSM) highlights the need to undertake a minimum of 150 min/week (i.e., accumulated in bouts of ≥10 min) of aerobic exercise of moderate to vigorous intensity in adults [18]. In a sample of women with SLE with mild/inactive disease, we cross-sectionally observed no association between accelerometer-assessed physical activity and arterial stiffness [19], although a higher level of cardiorespiratory fitness was related to lower age-related arterial stiffness in this population [20]. Although aerobic exercise has a promising role attenuating arterial stiffness in the general population [21], its effects in women with SLE have not been previously investigated.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

Soriano‐Maldonado

Morillas-de-Laguno

Sabio

et al. 2018

JCM

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This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

Soriano‐Maldonado

Morillas-de-Laguno

Sabio

et al. 2018

JCM

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“…Future studies should characterize the association of physical fitness with arterial stiffness in patients with SLE. Preliminary research from our group suggests that higher cardiorespiratory fitness could attenuate the age-related arterial stiffness in women with SLE [ 42 ]. Clinical trials should also address the extent to which meeting the minimum amount of aerobic exercise might positively influence arterial stiffness this population.…”

Section: Future Researchmentioning

confidence: 99%

Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity

et al. 2018

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ObjectivesTo examine the association of objectively measured physical activity (PA) intensity levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus (SLE) with mild disease activity and to analyze whether participants meeting the international PA guidelines have lower arterial stiffness than those not meeting the PA guidelines.MethodsThe study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9]) years, with clinical and treatment stability during the 6 months prior to the study. PA intensity levels and sedentary time were objectively measured with triaxial accelerometry. Arterial stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph® 24h pulse wave analysis monitor.ResultsThe average time in moderate to vigorous PA in bouts of ≥10 consecutive minutes was 135.1±151.8 minutes per week. There was no association of PA intensity levels and sedentary time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280).ConclusionsOur results suggest that PA intensity levels and sedentary time are not associated with arterial stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting international PA guidelines did not present lower arterial stiffness than those not meeting the PA guidelines. Future prospective research is needed to better understand the association of PA and sedentary time with arterial stiffness in patients with SLE.

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“…Physical fitness is a strong health marker in the general population [20] and in other rheumatologic diseases including rheumatoid arthritis [21] and fibromyalgia [22–24], among others. It has been reported that patients with SLE present a reduced cardiorespiratory fitness (CRF) [4–7,25], muscular strength and functional capacity [26]. Functional aerobic impairment [6,25] and low levels of strength [26] in SLE are negatively correlated with perception of severity [6], fatigue [6,26], and age-related arterial stiffness [25].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that patients with SLE present a reduced cardiorespiratory fitness (CRF) [4–7,25], muscular strength and functional capacity [26]. Functional aerobic impairment [6,25] and low levels of strength [26] in SLE are negatively correlated with perception of severity [6], fatigue [6,26], and age-related arterial stiffness [25]. Furthermore, a fitness level below the criterion-referenced standards could lead to a premature loss of independence [27].…”

Section: Introductionmentioning

confidence: 99%

Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity

Gavilán‐Carrera¹,

Silva²,

Vargas‐Hitos³

et al. 2019

PLoS ONE

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Objectives To study the association of different components of physical fitness [flexibility, muscle strength and cardiorespiratory fitness (CRF)] and a clustered fitness score with health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and to analyze whether participants with high fitness level have better HRQoL. Methods This cross-sectional study included 70 women with SLE (aged 42.5; SD 13.9 years). The back-scratch test assessed flexibility, the 30-sec chair stand and handgrip strength tests assessed muscle strength, and the 6-min walk test ( n = 49) assessed CRF. HRQoL was assessed through the 36-item Short-Form Health Survey (SF-36). Results Flexibility was positively associated with the physical function dimension and the physical component summary (PCS) (r partial between 0.26 and 0.31; p <0.05), and negatively related with social functioning dimension (r partial = -0.26; p <0.05). Muscle strength was positively associated with the physical function, physical role, bodily pain dimensions and the PCS (r partial between 0.27 and 0.49; all p <0.05). CRF was positively associated with the physical function and bodily pain dimensions, and PCS (r partial between 0.39 and 0.65; all p <0.05). The clustered fitness score was associated with the physical function ( B = 17.16) and bodily pain ( B = 14.35) dimensions, and the PCS ( B = 6.02), all p <0.005. Patients with high fitness level had greater scores in the physical function, physical role, and bodily pain dimensions and the PCS, all p ≤0.05. Conclusions Our study suggests that muscle strength and CRF are positively associated with HRQoL, while flexibility showed contradictory results. These findings highlight the importance of maintaining adequate fitness levels in women with SLE.

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Cardiorespiratory fitness and age‐related arterial stiffness in women with systemic lupus erythematosus

Cited by 21 publications

References 43 publications

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity

Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity

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